Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.

Mineralo-organic nanoparticles form spontaneously in human body fluids when the concentrations of calcium and phosphate ions exceed saturation. We have shown previously that these mineralo-organic nanoparticles possess biomimetic properties and can reproduce the whole phenomenology of the so-called...

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Autores principales:	Cheng-Yeu Wu, Lena Young, David Young, Jan Martel, John D Young
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/536de1f9a028494ba0d98266246ab24b
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spelling	oai:doaj.org-article:536de1f9a028494ba0d98266246ab24b2021-11-18T08:53:49ZBions: a family of biomimetic mineralo-organic complexes derived from biological fluids.1932-620310.1371/journal.pone.0075501https://doaj.org/article/536de1f9a028494ba0d98266246ab24b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086546/?tool=EBIhttps://doaj.org/toc/1932-6203Mineralo-organic nanoparticles form spontaneously in human body fluids when the concentrations of calcium and phosphate ions exceed saturation. We have shown previously that these mineralo-organic nanoparticles possess biomimetic properties and can reproduce the whole phenomenology of the so-called nanobacteria-mineralized entities initially described as the smallest microorganisms on earth. Here, we examine the possibility that various charged elements and ions may form mineral nanoparticles with similar properties in biological fluids. Remarkably, all the elements tested, including sodium, magnesium, aluminum, calcium, manganese, iron, cobalt, nickel, copper, zinc, strontium, and barium form mineralo-organic particles with bacteria-like morphologies and other complex shapes following precipitation with phosphate in body fluids. Upon formation, these mineralo-organic particles, which we term bions, invariably accumulate carbonate apatite during incubation in biological fluids; yet, the particles also incorporate additional elements and thus reflect the ionic milieu in which they form. Bions initially harbor an amorphous mineral phase that gradually converts to crystals in culture. Our results show that serum produces a dual inhibition-seeding effect on bion formation. Using a comprehensive proteomic analysis, we identify a wide range of proteins that bind to these mineral particles during incubation in medium containing serum. The two main binding proteins identified, albumin and fetuin-A, act as both inhibitors and seeders of bions in culture. Notably, bions possess several biomimetic properties, including the possibility to increase in size and number and to be sub-cultured in fresh culture medium. Based on these results, we propose that bions represent biological, mineralo-organic particles that may form in the body under both physiological and pathological homeostasis conditions. These mineralo-organic particles may be part of a physiological cycle that regulates the function, transport and disposal of elements and minerals in the human body.Cheng-Yeu WuLena YoungDavid YoungJan MartelJohn D YoungPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75501 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cheng-Yeu Wu Lena Young David Young Jan Martel John D Young Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.
description	Mineralo-organic nanoparticles form spontaneously in human body fluids when the concentrations of calcium and phosphate ions exceed saturation. We have shown previously that these mineralo-organic nanoparticles possess biomimetic properties and can reproduce the whole phenomenology of the so-called nanobacteria-mineralized entities initially described as the smallest microorganisms on earth. Here, we examine the possibility that various charged elements and ions may form mineral nanoparticles with similar properties in biological fluids. Remarkably, all the elements tested, including sodium, magnesium, aluminum, calcium, manganese, iron, cobalt, nickel, copper, zinc, strontium, and barium form mineralo-organic particles with bacteria-like morphologies and other complex shapes following precipitation with phosphate in body fluids. Upon formation, these mineralo-organic particles, which we term bions, invariably accumulate carbonate apatite during incubation in biological fluids; yet, the particles also incorporate additional elements and thus reflect the ionic milieu in which they form. Bions initially harbor an amorphous mineral phase that gradually converts to crystals in culture. Our results show that serum produces a dual inhibition-seeding effect on bion formation. Using a comprehensive proteomic analysis, we identify a wide range of proteins that bind to these mineral particles during incubation in medium containing serum. The two main binding proteins identified, albumin and fetuin-A, act as both inhibitors and seeders of bions in culture. Notably, bions possess several biomimetic properties, including the possibility to increase in size and number and to be sub-cultured in fresh culture medium. Based on these results, we propose that bions represent biological, mineralo-organic particles that may form in the body under both physiological and pathological homeostasis conditions. These mineralo-organic particles may be part of a physiological cycle that regulates the function, transport and disposal of elements and minerals in the human body.
format	article
author	Cheng-Yeu Wu Lena Young David Young Jan Martel John D Young
author_facet	Cheng-Yeu Wu Lena Young David Young Jan Martel John D Young
author_sort	Cheng-Yeu Wu
title	Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.
title_short	Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.
title_full	Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.
title_fullStr	Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.
title_full_unstemmed	Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.
title_sort	bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/536de1f9a028494ba0d98266246ab24b
work_keys_str_mv	AT chengyeuwu bionsafamilyofbiomimeticmineraloorganiccomplexesderivedfrombiologicalfluids AT lenayoung bionsafamilyofbiomimeticmineraloorganiccomplexesderivedfrombiologicalfluids AT davidyoung bionsafamilyofbiomimeticmineraloorganiccomplexesderivedfrombiologicalfluids AT janmartel bionsafamilyofbiomimeticmineraloorganiccomplexesderivedfrombiologicalfluids AT johndyoung bionsafamilyofbiomimeticmineraloorganiccomplexesderivedfrombiologicalfluids
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Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.

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