Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.

Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis and in vivo multispectral noninvasive imaging during the...

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Autores principales:	John S Cho, Yi Guo, Romela Irene Ramos, Frank Hebroni, Seema B Plaisier, Caiyun Xuan, Jennifer L Granick, Hironori Matsushima, Akira Takashima, Yoichiro Iwakura, Ambrose L Cheung, Genhong Cheng, Delphine J Lee, Scott I Simon, Lloyd S Miller
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/537606f4a0f84c01b78748202198eeae
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spelling	oai:doaj.org-article:537606f4a0f84c01b78748202198eeae2021-11-18T06:06:18ZNeutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.1553-73661553-737410.1371/journal.ppat.1003047https://doaj.org/article/537606f4a0f84c01b78748202198eeae2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209417/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis and in vivo multispectral noninvasive imaging during the S. aureus infection revealed a strong functional and temporal association between neutrophil recruitment and IL-1β/IL-1R activation. Unexpectedly, neutrophils but not monocytes/macrophages or other MHCII-expressing antigen presenting cells were the predominant source of IL-1β at the site of infection. Furthermore, neutrophil-derived IL-1β was essential for host defense since adoptive transfer of IL-1β-expressing neutrophils was sufficient to restore the impaired neutrophil abscess formation in S. aureus-infected IL-1β-deficient mice. S. aureus-induced IL-1β production by neutrophils required TLR2, NOD2, FPR1 and the ASC/NLRP3 inflammasome in an α-toxin-dependent mechanism. Taken together, IL-1β and neutrophil abscess formation during an infection are functionally, temporally and spatially linked as a consequence of direct IL-1β production by neutrophils.John S ChoYi GuoRomela Irene RamosFrank HebroniSeema B PlaisierCaiyun XuanJennifer L GranickHironori MatsushimaAkira TakashimaYoichiro IwakuraAmbrose L CheungGenhong ChengDelphine J LeeScott I SimonLloyd S MillerPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 8, Iss 11, p e1003047 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 John S Cho Yi Guo Romela Irene Ramos Frank Hebroni Seema B Plaisier Caiyun Xuan Jennifer L Granick Hironori Matsushima Akira Takashima Yoichiro Iwakura Ambrose L Cheung Genhong Cheng Delphine J Lee Scott I Simon Lloyd S Miller Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.
description	Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis and in vivo multispectral noninvasive imaging during the S. aureus infection revealed a strong functional and temporal association between neutrophil recruitment and IL-1β/IL-1R activation. Unexpectedly, neutrophils but not monocytes/macrophages or other MHCII-expressing antigen presenting cells were the predominant source of IL-1β at the site of infection. Furthermore, neutrophil-derived IL-1β was essential for host defense since adoptive transfer of IL-1β-expressing neutrophils was sufficient to restore the impaired neutrophil abscess formation in S. aureus-infected IL-1β-deficient mice. S. aureus-induced IL-1β production by neutrophils required TLR2, NOD2, FPR1 and the ASC/NLRP3 inflammasome in an α-toxin-dependent mechanism. Taken together, IL-1β and neutrophil abscess formation during an infection are functionally, temporally and spatially linked as a consequence of direct IL-1β production by neutrophils.
format	article
author	John S Cho Yi Guo Romela Irene Ramos Frank Hebroni Seema B Plaisier Caiyun Xuan Jennifer L Granick Hironori Matsushima Akira Takashima Yoichiro Iwakura Ambrose L Cheung Genhong Cheng Delphine J Lee Scott I Simon Lloyd S Miller
author_facet	John S Cho Yi Guo Romela Irene Ramos Frank Hebroni Seema B Plaisier Caiyun Xuan Jennifer L Granick Hironori Matsushima Akira Takashima Yoichiro Iwakura Ambrose L Cheung Genhong Cheng Delphine J Lee Scott I Simon Lloyd S Miller
author_sort	John S Cho
title	Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.
title_short	Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.
title_full	Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.
title_fullStr	Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.
title_full_unstemmed	Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.
title_sort	neutrophil-derived il-1β is sufficient for abscess formation in immunity against staphylococcus aureus in mice.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/537606f4a0f84c01b78748202198eeae
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Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.

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