Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration

While young muscle faithfully regenerates damaged myofibers, aged muscle is impaired. Here the authors show the “anti-aging” protein α-Klotho is upregulated in young muscle after damage via promoter demethylation and this regulation is lost in aging, resulting in mitochondrial damage and an impaired...

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Autores principales:	A. Sahu, H. Mamiya, S. N. Shinde, A. Cheikhi, L. L. Winter, N. V. Vo, D. Stolz, V. Roginskaya, W. Y. Tang, C. St. Croix, L. H. Sanders, M. Franti, B. Van Houten, T. A. Rando, A. Barchowsky, F. Ambrosio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53764cebf6a44636a5b9192ff210a0e8
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spelling	oai:doaj.org-article:53764cebf6a44636a5b9192ff210a0e82021-12-02T14:39:05ZAge-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration10.1038/s41467-018-07253-32041-1723https://doaj.org/article/53764cebf6a44636a5b9192ff210a0e82018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07253-3https://doaj.org/toc/2041-1723While young muscle faithfully regenerates damaged myofibers, aged muscle is impaired. Here the authors show the “anti-aging” protein α-Klotho is upregulated in young muscle after damage via promoter demethylation and this regulation is lost in aging, resulting in mitochondrial damage and an impaired healing response.A. SahuH. MamiyaS. N. ShindeA. CheikhiL. L. WinterN. V. VoD. StolzV. RoginskayaW. Y. TangC. St. CroixL. H. SandersM. FrantiB. Van HoutenT. A. RandoA. BarchowskyF. AmbrosioNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Sahu H. Mamiya S. N. Shinde A. Cheikhi L. L. Winter N. V. Vo D. Stolz V. Roginskaya W. Y. Tang C. St. Croix L. H. Sanders M. Franti B. Van Houten T. A. Rando A. Barchowsky F. Ambrosio Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
description	While young muscle faithfully regenerates damaged myofibers, aged muscle is impaired. Here the authors show the “anti-aging” protein α-Klotho is upregulated in young muscle after damage via promoter demethylation and this regulation is lost in aging, resulting in mitochondrial damage and an impaired healing response.
format	article
author	A. Sahu H. Mamiya S. N. Shinde A. Cheikhi L. L. Winter N. V. Vo D. Stolz V. Roginskaya W. Y. Tang C. St. Croix L. H. Sanders M. Franti B. Van Houten T. A. Rando A. Barchowsky F. Ambrosio
author_facet	A. Sahu H. Mamiya S. N. Shinde A. Cheikhi L. L. Winter N. V. Vo D. Stolz V. Roginskaya W. Y. Tang C. St. Croix L. H. Sanders M. Franti B. Van Houten T. A. Rando A. Barchowsky F. Ambrosio
author_sort	A. Sahu
title	Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
title_short	Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
title_full	Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
title_fullStr	Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
title_full_unstemmed	Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
title_sort	age-related declines in α-klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/53764cebf6a44636a5b9192ff210a0e8
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Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration

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