Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study

Abstract One of the reasons for high mortality of breast cancer (BC) is long delay in seeking medical care and end stage at presentation. This study was designed to measure the association between a wide range of socio-demographic and clinical factors with diagnostic delay in BC and stage at present...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elahe Foroozani, Reza Ghiasvand, Mohammad Mohammadianpanah, Sima Afrashteh, Dariush Bastam, Fatemeh Kashefi, Saba Shakarami, Mostafa Dianatinasab
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5378923a569e400da09f3c46956449d7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5378923a569e400da09f3c46956449d7
record_format	dspace
spelling	oai:doaj.org-article:5378923a569e400da09f3c46956449d72021-12-02T15:11:50ZDeterminants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study10.1038/s41598-020-78517-62045-2322https://doaj.org/article/5378923a569e400da09f3c46956449d72020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78517-6https://doaj.org/toc/2045-2322Abstract One of the reasons for high mortality of breast cancer (BC) is long delay in seeking medical care and end stage at presentation. This study was designed to measure the association between a wide range of socio-demographic and clinical factors with diagnostic delay in BC and stage at presentation among Iranian patients. From June 2017 to December 2019, 725 patients with newly diagnosed BC in Shiraz and Kermanshah were selected and information on BC diagnosis delay was obtained from the patient’s medical record. Data on socio-economic status was obtained via a structured interview. Our findings suggest that 45.8% of the patients were diagnosed at a late stage (stage 3 or higher). A total of 244 (34%) patients had more than 3 months delay in diagnosis. We found a significant association between stage at diagnosis and place of residence (adjusted odds ratio (aOR rural vs. urban = 1.69, 95% CI 1.49–1.97), marital status (aOR 1.61, 95% CI 1.42–1.88), family history of BC (aOR 1.46, 95% CI 1.01–2.13), and history of benign breast disease (BBD) (aOR 1.94, 95% CI 1.39–2.72) or unaware of breast self-examination (BSE) (aOR 1.42, 95% CI 1.42–1.85), delay time (aOR 3.25, 95% CI 1.04–5.21), and left breast tumor (aOR right vs. left 2.64, 95% CI 1.88–3.71) and smoking (aOR no vs. yes 1.59, 95% CI 1.36–1.97). Also, delay in diagnosis was associated with age, family income, health insurance, place of residence, marital status, menopausal status, history of BBD, awareness of breast self-examination, type of first symptoms, tumor histology type, BMI and comorbidity (p < 0.05 for all). Factors including history of BBD, awareness of BSE, and suffering from chronic diseases were factors associated with both delay in diagnosis and end stage of disease. These mainly modifiable factors are associated with the progression of the disease.Elahe ForoozaniReza GhiasvandMohammad MohammadianpanahSima AfrashtehDariush BastamFatemeh KashefiSaba ShakaramiMostafa DianatinasabNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elahe Foroozani Reza Ghiasvand Mohammad Mohammadianpanah Sima Afrashteh Dariush Bastam Fatemeh Kashefi Saba Shakarami Mostafa Dianatinasab Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study
description	Abstract One of the reasons for high mortality of breast cancer (BC) is long delay in seeking medical care and end stage at presentation. This study was designed to measure the association between a wide range of socio-demographic and clinical factors with diagnostic delay in BC and stage at presentation among Iranian patients. From June 2017 to December 2019, 725 patients with newly diagnosed BC in Shiraz and Kermanshah were selected and information on BC diagnosis delay was obtained from the patient’s medical record. Data on socio-economic status was obtained via a structured interview. Our findings suggest that 45.8% of the patients were diagnosed at a late stage (stage 3 or higher). A total of 244 (34%) patients had more than 3 months delay in diagnosis. We found a significant association between stage at diagnosis and place of residence (adjusted odds ratio (aOR rural vs. urban = 1.69, 95% CI 1.49–1.97), marital status (aOR 1.61, 95% CI 1.42–1.88), family history of BC (aOR 1.46, 95% CI 1.01–2.13), and history of benign breast disease (BBD) (aOR 1.94, 95% CI 1.39–2.72) or unaware of breast self-examination (BSE) (aOR 1.42, 95% CI 1.42–1.85), delay time (aOR 3.25, 95% CI 1.04–5.21), and left breast tumor (aOR right vs. left 2.64, 95% CI 1.88–3.71) and smoking (aOR no vs. yes 1.59, 95% CI 1.36–1.97). Also, delay in diagnosis was associated with age, family income, health insurance, place of residence, marital status, menopausal status, history of BBD, awareness of breast self-examination, type of first symptoms, tumor histology type, BMI and comorbidity (p < 0.05 for all). Factors including history of BBD, awareness of BSE, and suffering from chronic diseases were factors associated with both delay in diagnosis and end stage of disease. These mainly modifiable factors are associated with the progression of the disease.
format	article
author	Elahe Foroozani Reza Ghiasvand Mohammad Mohammadianpanah Sima Afrashteh Dariush Bastam Fatemeh Kashefi Saba Shakarami Mostafa Dianatinasab
author_facet	Elahe Foroozani Reza Ghiasvand Mohammad Mohammadianpanah Sima Afrashteh Dariush Bastam Fatemeh Kashefi Saba Shakarami Mostafa Dianatinasab
author_sort	Elahe Foroozani
title	Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study
title_short	Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study
title_full	Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study
title_fullStr	Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study
title_full_unstemmed	Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study
title_sort	determinants of delay in diagnosis and end stage at presentation among breast cancer patients in iran: a multi-center study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5378923a569e400da09f3c46956449d7
work_keys_str_mv	AT elaheforoozani determinantsofdelayindiagnosisandendstageatpresentationamongbreastcancerpatientsiniranamulticenterstudy AT rezaghiasvand determinantsofdelayindiagnosisandendstageatpresentationamongbreastcancerpatientsiniranamulticenterstudy AT mohammadmohammadianpanah determinantsofdelayindiagnosisandendstageatpresentationamongbreastcancerpatientsiniranamulticenterstudy AT simaafrashteh determinantsofdelayindiagnosisandendstageatpresentationamongbreastcancerpatientsiniranamulticenterstudy AT dariushbastam determinantsofdelayindiagnosisandendstageatpresentationamongbreastcancerpatientsiniranamulticenterstudy AT fatemehkashefi determinantsofdelayindiagnosisandendstageatpresentationamongbreastcancerpatientsiniranamulticenterstudy AT sabashakarami determinantsofdelayindiagnosisandendstageatpresentationamongbreastcancerpatientsiniranamulticenterstudy AT mostafadianatinasab determinantsofdelayindiagnosisandendstageatpresentationamongbreastcancerpatientsiniranamulticenterstudy
_version_	1718387628457328640

Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study

Ejemplares similares