Methods Used to Evaluate the Immediate Effects of Airway Clearance Techniques in Adults with Cystic Fibrosis: A Systematic Review and Meta-Analysis

This review reports on methods used to evaluate airway clearance techniques (ACT) in adults with CF and examined data for evidence of any effect. Sixty-eight studies described ACT in adequate detail and were included in this review. Frequently reported outcomes were sputum expectoration (72%) and sp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Naomi Chapman, Kathryn Watson, Tamara Hatton, Vinicius Cavalheri, Jamie Wood, Daniel F. Gucciardi, Elizabeth F. Smith, Kylie Hill
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cystic fibrosis adults airway clearance chest physiotherapy outcome measures Medicine R
Acceso en línea:	https://doaj.org/article/537a2c8e1e744b4d926b18532ea3f1cd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:537a2c8e1e744b4d926b18532ea3f1cd
record_format	dspace
spelling	oai:doaj.org-article:537a2c8e1e744b4d926b18532ea3f1cd2021-11-25T18:01:18ZMethods Used to Evaluate the Immediate Effects of Airway Clearance Techniques in Adults with Cystic Fibrosis: A Systematic Review and Meta-Analysis10.3390/jcm102252802077-0383https://doaj.org/article/537a2c8e1e744b4d926b18532ea3f1cd2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5280https://doaj.org/toc/2077-0383This review reports on methods used to evaluate airway clearance techniques (ACT) in adults with CF and examined data for evidence of any effect. Sixty-eight studies described ACT in adequate detail and were included in this review. Frequently reported outcomes were sputum expectoration (72%) and spirometric lung function (60%). Compared with cough alone, following any ACT, there was a trend for greater sputum wet weight, however FEV<sub>1</sub> was not different. The mean (95% CI) within-group effect for sputum wet weight following any ACT was 12.43 g (9.28 to 15.58) (<i>n</i> = 30 studies) and for FEV<sub>1</sub> was 0.03 L (−0.17 to 0.24) (<i>n</i> = 14 studies). Meta-regression demonstrated that, when compared with cough alone, greater sputum wet weight was reported in groups that received additional ACT by between 2.45 and 3.94 g (F<sub>3,66</sub> = 2.97, <i>p</i> = 0.04). These data suggest the addition of ACT to cough alone may optimise sputum clearance; however, FEV<sub>1</sub> lacked sensitivity to detect this change. Importantly, this review highlights the lack of appropriate measures to assess ACT efficacy.Naomi ChapmanKathryn WatsonTamara HattonVinicius CavalheriJamie WoodDaniel F. GucciardiElizabeth F. SmithKylie HillMDPI AGarticlecystic fibrosisadultsairway clearancechest physiotherapyoutcome measuresMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5280, p 5280 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cystic fibrosis adults airway clearance chest physiotherapy outcome measures Medicine R
spellingShingle	cystic fibrosis adults airway clearance chest physiotherapy outcome measures Medicine R Naomi Chapman Kathryn Watson Tamara Hatton Vinicius Cavalheri Jamie Wood Daniel F. Gucciardi Elizabeth F. Smith Kylie Hill Methods Used to Evaluate the Immediate Effects of Airway Clearance Techniques in Adults with Cystic Fibrosis: A Systematic Review and Meta-Analysis
description	This review reports on methods used to evaluate airway clearance techniques (ACT) in adults with CF and examined data for evidence of any effect. Sixty-eight studies described ACT in adequate detail and were included in this review. Frequently reported outcomes were sputum expectoration (72%) and spirometric lung function (60%). Compared with cough alone, following any ACT, there was a trend for greater sputum wet weight, however FEV<sub>1</sub> was not different. The mean (95% CI) within-group effect for sputum wet weight following any ACT was 12.43 g (9.28 to 15.58) (<i>n</i> = 30 studies) and for FEV<sub>1</sub> was 0.03 L (−0.17 to 0.24) (<i>n</i> = 14 studies). Meta-regression demonstrated that, when compared with cough alone, greater sputum wet weight was reported in groups that received additional ACT by between 2.45 and 3.94 g (F<sub>3,66</sub> = 2.97, <i>p</i> = 0.04). These data suggest the addition of ACT to cough alone may optimise sputum clearance; however, FEV<sub>1</sub> lacked sensitivity to detect this change. Importantly, this review highlights the lack of appropriate measures to assess ACT efficacy.
format	article
author	Naomi Chapman Kathryn Watson Tamara Hatton Vinicius Cavalheri Jamie Wood Daniel F. Gucciardi Elizabeth F. Smith Kylie Hill
author_facet	Naomi Chapman Kathryn Watson Tamara Hatton Vinicius Cavalheri Jamie Wood Daniel F. Gucciardi Elizabeth F. Smith Kylie Hill
author_sort	Naomi Chapman
title	Methods Used to Evaluate the Immediate Effects of Airway Clearance Techniques in Adults with Cystic Fibrosis: A Systematic Review and Meta-Analysis
title_short	Methods Used to Evaluate the Immediate Effects of Airway Clearance Techniques in Adults with Cystic Fibrosis: A Systematic Review and Meta-Analysis
title_full	Methods Used to Evaluate the Immediate Effects of Airway Clearance Techniques in Adults with Cystic Fibrosis: A Systematic Review and Meta-Analysis
title_fullStr	Methods Used to Evaluate the Immediate Effects of Airway Clearance Techniques in Adults with Cystic Fibrosis: A Systematic Review and Meta-Analysis
title_full_unstemmed	Methods Used to Evaluate the Immediate Effects of Airway Clearance Techniques in Adults with Cystic Fibrosis: A Systematic Review and Meta-Analysis
title_sort	methods used to evaluate the immediate effects of airway clearance techniques in adults with cystic fibrosis: a systematic review and meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/537a2c8e1e744b4d926b18532ea3f1cd
work_keys_str_mv	AT naomichapman methodsusedtoevaluatetheimmediateeffectsofairwayclearancetechniquesinadultswithcysticfibrosisasystematicreviewandmetaanalysis AT kathrynwatson methodsusedtoevaluatetheimmediateeffectsofairwayclearancetechniquesinadultswithcysticfibrosisasystematicreviewandmetaanalysis AT tamarahatton methodsusedtoevaluatetheimmediateeffectsofairwayclearancetechniquesinadultswithcysticfibrosisasystematicreviewandmetaanalysis AT viniciuscavalheri methodsusedtoevaluatetheimmediateeffectsofairwayclearancetechniquesinadultswithcysticfibrosisasystematicreviewandmetaanalysis AT jamiewood methodsusedtoevaluatetheimmediateeffectsofairwayclearancetechniquesinadultswithcysticfibrosisasystematicreviewandmetaanalysis AT danielfgucciardi methodsusedtoevaluatetheimmediateeffectsofairwayclearancetechniquesinadultswithcysticfibrosisasystematicreviewandmetaanalysis AT elizabethfsmith methodsusedtoevaluatetheimmediateeffectsofairwayclearancetechniquesinadultswithcysticfibrosisasystematicreviewandmetaanalysis AT kyliehill methodsusedtoevaluatetheimmediateeffectsofairwayclearancetechniquesinadultswithcysticfibrosisasystematicreviewandmetaanalysis
_version_	1718411742499831808

Methods Used to Evaluate the Immediate Effects of Airway Clearance Techniques in Adults with Cystic Fibrosis: A Systematic Review and Meta-Analysis

Ejemplares similares