Early postoperative weight gain is associated with increased risk of graft failure in living donor liver transplant recipients

Abstract Fluid overload (FO) has been shown to adversely affect multiple organs and survival in critically ill patients. Liver transplantation (LT) carries the risk of massive transfusion, which frequently results in FO. We investigated the association of postoperative weight gain with graft failure...

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Autores principales:	Hye-Won Jeong, Kyeo-Woon Jung, Seon-Ok Kim, Hye-Mee Kwon, Young-Jin Moon, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/537dc26c4e1a4857ac458dd1c0006ba5
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spelling	oai:doaj.org-article:537dc26c4e1a4857ac458dd1c0006ba52021-12-02T13:34:54ZEarly postoperative weight gain is associated with increased risk of graft failure in living donor liver transplant recipients10.1038/s41598-019-56543-32045-2322https://doaj.org/article/537dc26c4e1a4857ac458dd1c0006ba52019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56543-3https://doaj.org/toc/2045-2322Abstract Fluid overload (FO) has been shown to adversely affect multiple organs and survival in critically ill patients. Liver transplantation (LT) carries the risk of massive transfusion, which frequently results in FO. We investigated the association of postoperative weight gain with graft failure, early allograft dysfunction (EAD), and overall mortality in LT. 1833 living donor LT (LDLT) recipients were retrospectively analysed. Patients were divided into 2 groups according to postoperative weight gain (<3% group [n = 1391] and ≥3% group [n = 442]) by using maximally selected log-rank statistics for graft failure. Multivariate Cox and logistic regression analyses were performed. The ≥3% group was associated with graft failure (adjusted HR [aHR], 1.763; 95% CI, 1.248–2.490; P = 0.001). When postoperative weight change was used as a continuous variable, the aHR for each 1% increase in postoperative weight was 1.045 (95% CI, 1.009–1.082; P = 0.015). In addition, the ≥3% group was associated with EAD (adjusted OR [aOR], 1.553; 95% CI, 1.024–2.356; P = 0.038) and overall mortality (aHR, 1.731; 95% CI, 1.182–2.535; P = 0.005). In conclusion, postoperative weight gain may be independently associated with increased risk of graft failure, EAD, and mortality in LDLT recipients.Hye-Won JeongKyeo-Woon JungSeon-Ok KimHye-Mee KwonYoung-Jin MoonIn-Gu JunJun-Gol SongGyu-Sam HwangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hye-Won Jeong Kyeo-Woon Jung Seon-Ok Kim Hye-Mee Kwon Young-Jin Moon In-Gu Jun Jun-Gol Song Gyu-Sam Hwang Early postoperative weight gain is associated with increased risk of graft failure in living donor liver transplant recipients
description	Abstract Fluid overload (FO) has been shown to adversely affect multiple organs and survival in critically ill patients. Liver transplantation (LT) carries the risk of massive transfusion, which frequently results in FO. We investigated the association of postoperative weight gain with graft failure, early allograft dysfunction (EAD), and overall mortality in LT. 1833 living donor LT (LDLT) recipients were retrospectively analysed. Patients were divided into 2 groups according to postoperative weight gain (<3% group [n = 1391] and ≥3% group [n = 442]) by using maximally selected log-rank statistics for graft failure. Multivariate Cox and logistic regression analyses were performed. The ≥3% group was associated with graft failure (adjusted HR [aHR], 1.763; 95% CI, 1.248–2.490; P = 0.001). When postoperative weight change was used as a continuous variable, the aHR for each 1% increase in postoperative weight was 1.045 (95% CI, 1.009–1.082; P = 0.015). In addition, the ≥3% group was associated with EAD (adjusted OR [aOR], 1.553; 95% CI, 1.024–2.356; P = 0.038) and overall mortality (aHR, 1.731; 95% CI, 1.182–2.535; P = 0.005). In conclusion, postoperative weight gain may be independently associated with increased risk of graft failure, EAD, and mortality in LDLT recipients.
format	article
author	Hye-Won Jeong Kyeo-Woon Jung Seon-Ok Kim Hye-Mee Kwon Young-Jin Moon In-Gu Jun Jun-Gol Song Gyu-Sam Hwang
author_facet	Hye-Won Jeong Kyeo-Woon Jung Seon-Ok Kim Hye-Mee Kwon Young-Jin Moon In-Gu Jun Jun-Gol Song Gyu-Sam Hwang
author_sort	Hye-Won Jeong
title	Early postoperative weight gain is associated with increased risk of graft failure in living donor liver transplant recipients
title_short	Early postoperative weight gain is associated with increased risk of graft failure in living donor liver transplant recipients
title_full	Early postoperative weight gain is associated with increased risk of graft failure in living donor liver transplant recipients
title_fullStr	Early postoperative weight gain is associated with increased risk of graft failure in living donor liver transplant recipients
title_full_unstemmed	Early postoperative weight gain is associated with increased risk of graft failure in living donor liver transplant recipients
title_sort	early postoperative weight gain is associated with increased risk of graft failure in living donor liver transplant recipients
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/537dc26c4e1a4857ac458dd1c0006ba5
work_keys_str_mv	AT hyewonjeong earlypostoperativeweightgainisassociatedwithincreasedriskofgraftfailureinlivingdonorlivertransplantrecipients AT kyeowoonjung earlypostoperativeweightgainisassociatedwithincreasedriskofgraftfailureinlivingdonorlivertransplantrecipients AT seonokkim earlypostoperativeweightgainisassociatedwithincreasedriskofgraftfailureinlivingdonorlivertransplantrecipients AT hyemeekwon earlypostoperativeweightgainisassociatedwithincreasedriskofgraftfailureinlivingdonorlivertransplantrecipients AT youngjinmoon earlypostoperativeweightgainisassociatedwithincreasedriskofgraftfailureinlivingdonorlivertransplantrecipients AT ingujun earlypostoperativeweightgainisassociatedwithincreasedriskofgraftfailureinlivingdonorlivertransplantrecipients AT jungolsong earlypostoperativeweightgainisassociatedwithincreasedriskofgraftfailureinlivingdonorlivertransplantrecipients AT gyusamhwang earlypostoperativeweightgainisassociatedwithincreasedriskofgraftfailureinlivingdonorlivertransplantrecipients
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Early postoperative weight gain is associated with increased risk of graft failure in living donor liver transplant recipients

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