An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation

Mechanical forces are sensed by cells and can alter plasma membrane properties, but biochemical changes underlying this are not clear. Here the authors show tension is sensed by c-Abl and FBP17, which couples changes in mechanical tension to remodelling of the plasma membrane and actin cytoskeleton.

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Autores principales:	Asier Echarri, Dácil M. Pavón, Sara Sánchez, María García-García, Enrique Calvo, Carla Huerta-López, Diana Velázquez-Carreras, Christine Viaris de Lesegno, Nicholas Ariotti, Ana Lázaro-Carrillo, Raffaele Strippoli, David De Sancho, Jorge Alegre-Cebollada, Christophe Lamaze, Robert G. Parton, Miguel A. Del Pozo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/537e84a3f682496786a15fc617c6a1d4
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spelling	oai:doaj.org-article:537e84a3f682496786a15fc617c6a1d42021-12-02T16:50:58ZAn Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation10.1038/s41467-019-13782-22041-1723https://doaj.org/article/537e84a3f682496786a15fc617c6a1d42019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13782-2https://doaj.org/toc/2041-1723Mechanical forces are sensed by cells and can alter plasma membrane properties, but biochemical changes underlying this are not clear. Here the authors show tension is sensed by c-Abl and FBP17, which couples changes in mechanical tension to remodelling of the plasma membrane and actin cytoskeleton.Asier EcharriDácil M. PavónSara SánchezMaría García-GarcíaEnrique CalvoCarla Huerta-LópezDiana Velázquez-CarrerasChristine Viaris de LesegnoNicholas AriottiAna Lázaro-CarrilloRaffaele StrippoliDavid De SanchoJorge Alegre-CebolladaChristophe LamazeRobert G. PartonMiguel A. Del PozoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Asier Echarri Dácil M. Pavón Sara Sánchez María García-García Enrique Calvo Carla Huerta-López Diana Velázquez-Carreras Christine Viaris de Lesegno Nicholas Ariotti Ana Lázaro-Carrillo Raffaele Strippoli David De Sancho Jorge Alegre-Cebollada Christophe Lamaze Robert G. Parton Miguel A. Del Pozo An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation
description	Mechanical forces are sensed by cells and can alter plasma membrane properties, but biochemical changes underlying this are not clear. Here the authors show tension is sensed by c-Abl and FBP17, which couples changes in mechanical tension to remodelling of the plasma membrane and actin cytoskeleton.
format	article
author	Asier Echarri Dácil M. Pavón Sara Sánchez María García-García Enrique Calvo Carla Huerta-López Diana Velázquez-Carreras Christine Viaris de Lesegno Nicholas Ariotti Ana Lázaro-Carrillo Raffaele Strippoli David De Sancho Jorge Alegre-Cebollada Christophe Lamaze Robert G. Parton Miguel A. Del Pozo
author_facet	Asier Echarri Dácil M. Pavón Sara Sánchez María García-García Enrique Calvo Carla Huerta-López Diana Velázquez-Carreras Christine Viaris de Lesegno Nicholas Ariotti Ana Lázaro-Carrillo Raffaele Strippoli David De Sancho Jorge Alegre-Cebollada Christophe Lamaze Robert G. Parton Miguel A. Del Pozo
author_sort	Asier Echarri
title	An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation
title_short	An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation
title_full	An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation
title_fullStr	An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation
title_full_unstemmed	An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation
title_sort	abl-fbp17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/537e84a3f682496786a15fc617c6a1d4
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An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation

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