Comparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a Mexican population with primary open-angle glaucoma or ocular hypertension

Leopoldo Mart&iacute;n Baiza-Dur&aacute;n, Juan Francisco Llamas-Moreno, Clotilde Ayala-BarajasClinical Research Department, Laboratorios Sophia, SA de CV Guadalajara, Jalisco, M&eacute;xicoBackground: The purpose of this study was to evaluate the efficacy and safety of two f...

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Autores principales:	Baiza-Dur&aacute;n LM, Llamas-Moreno JF, Ayala-Barajas C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/538090a0fb964ce79c5882cebf7556a0
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spelling	oai:doaj.org-article:538090a0fb964ce79c5882cebf7556a02021-12-02T11:54:53ZComparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a Mexican population with primary open-angle glaucoma or ocular hypertension1177-54671177-5483https://doaj.org/article/538090a0fb964ce79c5882cebf7556a02012-07-01T00:00:00Zhttp://www.dovepress.com/comparison-of-timolol-05--brimonidine-02--dorzolamide-2-versus-timolol-a10364https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Leopoldo Mart&iacute;n Baiza-Dur&aacute;n, Juan Francisco Llamas-Moreno, Clotilde Ayala-BarajasClinical Research Department, Laboratorios Sophia, SA de CV Guadalajara, Jalisco, M&eacute;xicoBackground: The purpose of this study was to evaluate the efficacy and safety of two fixed combinations, ie, timolol 0.5% + brimonidine 0.2% + dorzolamide 2% (TBD) versus timolol 0.5% + brimonidine 0.2% (TB) in patients with primary open-angle glaucoma or ocular hypertension.Methods: We performed a 3-month, randomized, double-blind study in patients with primary open-angle glaucoma or ocular hypertension and an intraocular pressure of 21&ndash;30 mmHg. Patients were randomly assigned to receive one drop of TBD or TB twice a day. The primary efficacy endpoint was change in intraocular pressure after 3 months of treatment. Safety measures were assessed by the presence of adverse events.Results: Mean baseline intraocular pressure was similar at 8 am and 4 pm in the treatment groups (TBD 22.3 &plusmn; 0.9 mmHg, TB 22.4 &plusmn; 1.8 mmHg, P = 0.558; TBD 19.02 &plusmn; 1.3, TB 19.08 &plusmn; 1.2, P = 0.536, respectively). At the end of the study, the mean intraocular pressure was significantly lower in the TBD group at both 8 am (16.19 &plusmn; 2.0 mmHg versus 18.35 &plusmn; 1.4 mmHg, P = 0.000) and 4 pm (14.74 &plusmn; 2.4 mmHg versus 16.77 &plusmn; 1.4 mmHg, P = 0.000).Conclusion: Fixed-combination TBD was more effective than fixed-combination TB for reducing IOP in patients with primary open-angle glaucoma.Keywords: primary open-angle glaucoma, ocular hypertension, intraocular pressure, fixed combinationBaiza-Dur&aacute;n LMLlamas-Moreno JFAyala-Barajas CDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 1051-1055 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Baiza-Dur&aacute;n LM Llamas-Moreno JF Ayala-Barajas C Comparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a Mexican population with primary open-angle glaucoma or ocular hypertension
description	Leopoldo Mart&iacute;n Baiza-Dur&aacute;n, Juan Francisco Llamas-Moreno, Clotilde Ayala-BarajasClinical Research Department, Laboratorios Sophia, SA de CV Guadalajara, Jalisco, M&eacute;xicoBackground: The purpose of this study was to evaluate the efficacy and safety of two fixed combinations, ie, timolol 0.5% + brimonidine 0.2% + dorzolamide 2% (TBD) versus timolol 0.5% + brimonidine 0.2% (TB) in patients with primary open-angle glaucoma or ocular hypertension.Methods: We performed a 3-month, randomized, double-blind study in patients with primary open-angle glaucoma or ocular hypertension and an intraocular pressure of 21&ndash;30 mmHg. Patients were randomly assigned to receive one drop of TBD or TB twice a day. The primary efficacy endpoint was change in intraocular pressure after 3 months of treatment. Safety measures were assessed by the presence of adverse events.Results: Mean baseline intraocular pressure was similar at 8 am and 4 pm in the treatment groups (TBD 22.3 &plusmn; 0.9 mmHg, TB 22.4 &plusmn; 1.8 mmHg, P = 0.558; TBD 19.02 &plusmn; 1.3, TB 19.08 &plusmn; 1.2, P = 0.536, respectively). At the end of the study, the mean intraocular pressure was significantly lower in the TBD group at both 8 am (16.19 &plusmn; 2.0 mmHg versus 18.35 &plusmn; 1.4 mmHg, P = 0.000) and 4 pm (14.74 &plusmn; 2.4 mmHg versus 16.77 &plusmn; 1.4 mmHg, P = 0.000).Conclusion: Fixed-combination TBD was more effective than fixed-combination TB for reducing IOP in patients with primary open-angle glaucoma.Keywords: primary open-angle glaucoma, ocular hypertension, intraocular pressure, fixed combination
format	article
author	Baiza-Dur&aacute;n LM Llamas-Moreno JF Ayala-Barajas C
author_facet	Baiza-Dur&aacute;n LM Llamas-Moreno JF Ayala-Barajas C
author_sort	Baiza-Dur&aacute;n LM
title	Comparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a Mexican population with primary open-angle glaucoma or ocular hypertension
title_short	Comparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a Mexican population with primary open-angle glaucoma or ocular hypertension
title_full	Comparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a Mexican population with primary open-angle glaucoma or ocular hypertension
title_fullStr	Comparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a Mexican population with primary open-angle glaucoma or ocular hypertension
title_full_unstemmed	Comparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a Mexican population with primary open-angle glaucoma or ocular hypertension
title_sort	comparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a mexican population with primary open-angle glaucoma or ocular hypertension
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/538090a0fb964ce79c5882cebf7556a0
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Comparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a Mexican population with primary open-angle glaucoma or ocular hypertension

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