Quantitative analysis of internal components of the human crystalline lens during accommodation in adults

Abstract To quantitatively analyze changes in the inner components of the human crystalline lens during accommodation in adults. Eyes of 23 subjects were sequentially examined using CASIA2 Optical Coherence Tomography under 0D, − 3D and − 6D accommodation states. The anterior chamber depth (ACD), an...

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Autores principales:	Yan Xiang, Ting Fu, Qiongfang Xu, Wei Chen, Zhiqi Chen, Jinming Guo, Chaohua Deng, Anne Manyande, Ping Wang, Hong Zhang, Xuebi Tian, Junming Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/53835e4e1173458aab6a3431d62dfe90
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spelling	oai:doaj.org-article:53835e4e1173458aab6a3431d62dfe902021-12-02T13:24:14ZQuantitative analysis of internal components of the human crystalline lens during accommodation in adults10.1038/s41598-021-86007-62045-2322https://doaj.org/article/53835e4e1173458aab6a3431d62dfe902021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86007-6https://doaj.org/toc/2045-2322Abstract To quantitatively analyze changes in the inner components of the human crystalline lens during accommodation in adults. Eyes of 23 subjects were sequentially examined using CASIA2 Optical Coherence Tomography under 0D, − 3D and − 6D accommodation states. The anterior chamber depth (ACD), anterior and posterior crystalline lens radius of the curvature (ALRC and PLRC) were obtained using built-in software. The lens thickness (LT), lenticular nucleus thickness (NT), anterior cortex thickness (ACT), posterior cortex thickness (PCT), anterior and posterior lenticular nucleus radius of the curvature (ANRC and PNRC), anterior and posterior lenticular nucleus vertex (ANV and PNV) were quantified manually with the Image-pro plus software. During accommodation, the ACD became significantly shallower and LT significantly increased. For changes in the lens, the ALRC decreased by an average magnitude (related to accommodative stimuli) 0.44 mm/D, and PLRC decreased 0.09 mm/D. There was no difference for the ACT and PCT in different accommodation states. For lenticular nucleus response, NT increased on average by 30 μm/D. Both the ANRC and PNRC decreased on average by 212 μm/D and 115 μm/D respectively. The ANV moved forward on average by 0.07 mm under − 3D accommodative stimuli and 0.16 mm for − 6D. However, there was no statistically significant difference between different accommodation states in the PNV movement. Under accommodation stimulation, lens thickness changed mainly due to the lenticular nucleus, but not the cortex. For the lenticular nucleus, both the ANRC and PNRC decreased and ANRC changed the most. The anterior surface of the nucleus moved forward while the posterior surface of the nucleus moved backward but only slightly.Yan XiangTing FuQiongfang XuWei ChenZhiqi ChenJinming GuoChaohua DengAnne ManyandePing WangHong ZhangXuebi TianJunming WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan Xiang Ting Fu Qiongfang Xu Wei Chen Zhiqi Chen Jinming Guo Chaohua Deng Anne Manyande Ping Wang Hong Zhang Xuebi Tian Junming Wang Quantitative analysis of internal components of the human crystalline lens during accommodation in adults
description	Abstract To quantitatively analyze changes in the inner components of the human crystalline lens during accommodation in adults. Eyes of 23 subjects were sequentially examined using CASIA2 Optical Coherence Tomography under 0D, − 3D and − 6D accommodation states. The anterior chamber depth (ACD), anterior and posterior crystalline lens radius of the curvature (ALRC and PLRC) were obtained using built-in software. The lens thickness (LT), lenticular nucleus thickness (NT), anterior cortex thickness (ACT), posterior cortex thickness (PCT), anterior and posterior lenticular nucleus radius of the curvature (ANRC and PNRC), anterior and posterior lenticular nucleus vertex (ANV and PNV) were quantified manually with the Image-pro plus software. During accommodation, the ACD became significantly shallower and LT significantly increased. For changes in the lens, the ALRC decreased by an average magnitude (related to accommodative stimuli) 0.44 mm/D, and PLRC decreased 0.09 mm/D. There was no difference for the ACT and PCT in different accommodation states. For lenticular nucleus response, NT increased on average by 30 μm/D. Both the ANRC and PNRC decreased on average by 212 μm/D and 115 μm/D respectively. The ANV moved forward on average by 0.07 mm under − 3D accommodative stimuli and 0.16 mm for − 6D. However, there was no statistically significant difference between different accommodation states in the PNV movement. Under accommodation stimulation, lens thickness changed mainly due to the lenticular nucleus, but not the cortex. For the lenticular nucleus, both the ANRC and PNRC decreased and ANRC changed the most. The anterior surface of the nucleus moved forward while the posterior surface of the nucleus moved backward but only slightly.
format	article
author	Yan Xiang Ting Fu Qiongfang Xu Wei Chen Zhiqi Chen Jinming Guo Chaohua Deng Anne Manyande Ping Wang Hong Zhang Xuebi Tian Junming Wang
author_facet	Yan Xiang Ting Fu Qiongfang Xu Wei Chen Zhiqi Chen Jinming Guo Chaohua Deng Anne Manyande Ping Wang Hong Zhang Xuebi Tian Junming Wang
author_sort	Yan Xiang
title	Quantitative analysis of internal components of the human crystalline lens during accommodation in adults
title_short	Quantitative analysis of internal components of the human crystalline lens during accommodation in adults
title_full	Quantitative analysis of internal components of the human crystalline lens during accommodation in adults
title_fullStr	Quantitative analysis of internal components of the human crystalline lens during accommodation in adults
title_full_unstemmed	Quantitative analysis of internal components of the human crystalline lens during accommodation in adults
title_sort	quantitative analysis of internal components of the human crystalline lens during accommodation in adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/53835e4e1173458aab6a3431d62dfe90
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Quantitative analysis of internal components of the human crystalline lens during accommodation in adults

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