Role of Ferroptosis in Lung Diseases

Wenting Xu,1,2,* Huimin Deng,2,* Song Hu,2,3,* Yiguo Zhang,2,3 Li Zheng,1,2 Meiyun Liu,2 Yuanli Chen,2 Juan Wei,2 Hao Yang,2 Xin Lv1– 3 1Department of Anesthesiology, Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, 236000, People’s Republic of China; 2Department of An...

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Autores principales:	Xu W, Deng H, Hu S, Zhang Y, Zheng L, Liu M, Chen Y, Wei J, Yang H, Lv X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ferroptosis metabolic networks and pathways signalling pathways lung diseases Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/538455736a384e9e8ea5e6d298797ce5
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spelling	oai:doaj.org-article:538455736a384e9e8ea5e6d298797ce52021-12-02T17:17:11ZRole of Ferroptosis in Lung Diseases1178-7031https://doaj.org/article/538455736a384e9e8ea5e6d298797ce52021-05-01T00:00:00Zhttps://www.dovepress.com/role-of-ferroptosis-in-lung-diseases-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Wenting Xu,1,2,* Huimin Deng,2,* Song Hu,2,3,* Yiguo Zhang,2,3 Li Zheng,1,2 Meiyun Liu,2 Yuanli Chen,2 Juan Wei,2 Hao Yang,2 Xin Lv1– 3 1Department of Anesthesiology, Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, 236000, People’s Republic of China; 2Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 3Graduate School, Wannan Medical College, Wuhu, AnHui, 241002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Lv; Hao YangDepartment of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, People’s Republic of ChinaEmail xinlvg@126.com; yanghaozunyi@sina.comAbstract: Ferroptosis is a new type of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation that leads to oxidative stress and cell death. The metabolism of iron, lipids, and amino acids and multiple signalling pathways precisely regulate the process of ferroptosis. Emerging evidence has demonstrated that ferroptosis participates in the occurrence and progression of various pathological conditions and diseases, such as infections, neurodegeneration, tissue ischaemia-reperfusion injury and immune diseases. Recent studies have also indicated that ferroptosis plays a critical role in the pathogenesis of acute lung injury, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary infection and asthma. Herein, we summarize the latest knowledge on the regulatory mechanism of ferroptosis and its association with iron, lipid and amino acid metabolism as well as several signalling pathways. Furthermore, we review the contribution of ferroptosis to the pathogenesis of lung diseases and discuss ferroptosis as a novel therapeutic target for various lung diseases.Keywords: ferroptosis, metabolic networks and pathways, signalling pathways, lung diseasesXu WDeng HHu SZhang YZheng LLiu MChen YWei JYang HLv XDove Medical Pressarticleferroptosismetabolic networks and pathwayssignalling pathwayslung diseasesPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 2079-2090 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ferroptosis metabolic networks and pathways signalling pathways lung diseases Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	ferroptosis metabolic networks and pathways signalling pathways lung diseases Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Xu W Deng H Hu S Zhang Y Zheng L Liu M Chen Y Wei J Yang H Lv X Role of Ferroptosis in Lung Diseases
description	Wenting Xu,1,2,* Huimin Deng,2,* Song Hu,2,3,* Yiguo Zhang,2,3 Li Zheng,1,2 Meiyun Liu,2 Yuanli Chen,2 Juan Wei,2 Hao Yang,2 Xin Lv1– 3 1Department of Anesthesiology, Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, 236000, People’s Republic of China; 2Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 3Graduate School, Wannan Medical College, Wuhu, AnHui, 241002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Lv; Hao YangDepartment of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, People’s Republic of ChinaEmail xinlvg@126.com; yanghaozunyi@sina.comAbstract: Ferroptosis is a new type of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation that leads to oxidative stress and cell death. The metabolism of iron, lipids, and amino acids and multiple signalling pathways precisely regulate the process of ferroptosis. Emerging evidence has demonstrated that ferroptosis participates in the occurrence and progression of various pathological conditions and diseases, such as infections, neurodegeneration, tissue ischaemia-reperfusion injury and immune diseases. Recent studies have also indicated that ferroptosis plays a critical role in the pathogenesis of acute lung injury, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary infection and asthma. Herein, we summarize the latest knowledge on the regulatory mechanism of ferroptosis and its association with iron, lipid and amino acid metabolism as well as several signalling pathways. Furthermore, we review the contribution of ferroptosis to the pathogenesis of lung diseases and discuss ferroptosis as a novel therapeutic target for various lung diseases.Keywords: ferroptosis, metabolic networks and pathways, signalling pathways, lung diseases
format	article
author	Xu W Deng H Hu S Zhang Y Zheng L Liu M Chen Y Wei J Yang H Lv X
author_facet	Xu W Deng H Hu S Zhang Y Zheng L Liu M Chen Y Wei J Yang H Lv X
author_sort	Xu W
title	Role of Ferroptosis in Lung Diseases
title_short	Role of Ferroptosis in Lung Diseases
title_full	Role of Ferroptosis in Lung Diseases
title_fullStr	Role of Ferroptosis in Lung Diseases
title_full_unstemmed	Role of Ferroptosis in Lung Diseases
title_sort	role of ferroptosis in lung diseases
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/538455736a384e9e8ea5e6d298797ce5
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_version_	1718381144708218880

Role of Ferroptosis in Lung Diseases

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