Bone health in spacefaring rodents and primates: systematic review and meta-analysis

Abstract Animals in space exploration studies serve both as a model for human physiology and as a means to understand the physiological effects of microgravity. To quantify the microgravity-induced changes to bone health in animals, we systematically searched Medline, Embase, Web of Science, BIOSIS,...

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Autores principales:	Jingyan Fu, Matthew Goldsmith, Sequoia D. Crooks, Sean F. Condon, Martin Morris, Svetlana V. Komarova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/5384ced52f37482786ae0b63dde9cf18
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spelling	oai:doaj.org-article:5384ced52f37482786ae0b63dde9cf182021-12-02T15:03:04ZBone health in spacefaring rodents and primates: systematic review and meta-analysis10.1038/s41526-021-00147-72373-8065https://doaj.org/article/5384ced52f37482786ae0b63dde9cf182021-06-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00147-7https://doaj.org/toc/2373-8065Abstract Animals in space exploration studies serve both as a model for human physiology and as a means to understand the physiological effects of microgravity. To quantify the microgravity-induced changes to bone health in animals, we systematically searched Medline, Embase, Web of Science, BIOSIS, and NASA Technical reports. We selected 40 papers focusing on the bone health of 95 rats, 61 mice, and 9 rhesus monkeys from 22 space missions. The percentage difference from ground control in rodents was –24.1% [Confidence interval: −43.4, −4.9] for trabecular bone volume fraction and –5.9% [−8.0, −3.8] for the cortical area. In primates, trabecular bone volume fraction was lower by –25.2% [−35.6, −14.7] in spaceflight animals compared to GC. Bone formation indices in rodent trabecular and cortical bone were significantly lower in microgravity. In contrast, osteoclast numbers were not affected in rats and were variably affected in mice. Thus, microgravity induces bone deficits in rodents and primates likely through the suppression of bone formation.Jingyan FuMatthew GoldsmithSequoia D. CrooksSean F. CondonMartin MorrisSvetlana V. KomarovaNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Jingyan Fu Matthew Goldsmith Sequoia D. Crooks Sean F. Condon Martin Morris Svetlana V. Komarova Bone health in spacefaring rodents and primates: systematic review and meta-analysis
description	Abstract Animals in space exploration studies serve both as a model for human physiology and as a means to understand the physiological effects of microgravity. To quantify the microgravity-induced changes to bone health in animals, we systematically searched Medline, Embase, Web of Science, BIOSIS, and NASA Technical reports. We selected 40 papers focusing on the bone health of 95 rats, 61 mice, and 9 rhesus monkeys from 22 space missions. The percentage difference from ground control in rodents was –24.1% [Confidence interval: −43.4, −4.9] for trabecular bone volume fraction and –5.9% [−8.0, −3.8] for the cortical area. In primates, trabecular bone volume fraction was lower by –25.2% [−35.6, −14.7] in spaceflight animals compared to GC. Bone formation indices in rodent trabecular and cortical bone were significantly lower in microgravity. In contrast, osteoclast numbers were not affected in rats and were variably affected in mice. Thus, microgravity induces bone deficits in rodents and primates likely through the suppression of bone formation.
format	article
author	Jingyan Fu Matthew Goldsmith Sequoia D. Crooks Sean F. Condon Martin Morris Svetlana V. Komarova
author_facet	Jingyan Fu Matthew Goldsmith Sequoia D. Crooks Sean F. Condon Martin Morris Svetlana V. Komarova
author_sort	Jingyan Fu
title	Bone health in spacefaring rodents and primates: systematic review and meta-analysis
title_short	Bone health in spacefaring rodents and primates: systematic review and meta-analysis
title_full	Bone health in spacefaring rodents and primates: systematic review and meta-analysis
title_fullStr	Bone health in spacefaring rodents and primates: systematic review and meta-analysis
title_full_unstemmed	Bone health in spacefaring rodents and primates: systematic review and meta-analysis
title_sort	bone health in spacefaring rodents and primates: systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5384ced52f37482786ae0b63dde9cf18
work_keys_str_mv	AT jingyanfu bonehealthinspacefaringrodentsandprimatessystematicreviewandmetaanalysis AT matthewgoldsmith bonehealthinspacefaringrodentsandprimatessystematicreviewandmetaanalysis AT sequoiadcrooks bonehealthinspacefaringrodentsandprimatessystematicreviewandmetaanalysis AT seanfcondon bonehealthinspacefaringrodentsandprimatessystematicreviewandmetaanalysis AT martinmorris bonehealthinspacefaringrodentsandprimatessystematicreviewandmetaanalysis AT svetlanavkomarova bonehealthinspacefaringrodentsandprimatessystematicreviewandmetaanalysis
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Bone health in spacefaring rodents and primates: systematic review and meta-analysis

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