Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors

The reduction of 2-naphtoyl-CoA to 5,6 dihydro-2-naphtoyl-CoA by 2-naphtoyl-CoA reductase is below the negative redox limit usually encountered in biological hydride transfer. Here, via X-ray crystallography and spectroscopic analysis, the authors elucidated the mechanism behind this.

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Autores principales:	Max Willistein, Dominique F. Bechtel, Christina S. Müller, Ulrike Demmer, Larissa Heimann, Kanwal Kayastha, Volker Schünemann, Antonio J. Pierik, G. Matthias Ullmann, Ulrich Ermler, Matthias Boll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5384fcc9585141cc8574aa70b0d76cdc
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spelling	oai:doaj.org-article:5384fcc9585141cc8574aa70b0d76cdc2021-12-02T14:38:39ZLow potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors10.1038/s41467-019-10078-32041-1723https://doaj.org/article/5384fcc9585141cc8574aa70b0d76cdc2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10078-3https://doaj.org/toc/2041-1723The reduction of 2-naphtoyl-CoA to 5,6 dihydro-2-naphtoyl-CoA by 2-naphtoyl-CoA reductase is below the negative redox limit usually encountered in biological hydride transfer. Here, via X-ray crystallography and spectroscopic analysis, the authors elucidated the mechanism behind this.Max WillisteinDominique F. BechtelChristina S. MüllerUlrike DemmerLarissa HeimannKanwal KayasthaVolker SchünemannAntonio J. PierikG. Matthias UllmannUlrich ErmlerMatthias BollNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Max Willistein Dominique F. Bechtel Christina S. Müller Ulrike Demmer Larissa Heimann Kanwal Kayastha Volker Schünemann Antonio J. Pierik G. Matthias Ullmann Ulrich Ermler Matthias Boll Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors
description	The reduction of 2-naphtoyl-CoA to 5,6 dihydro-2-naphtoyl-CoA by 2-naphtoyl-CoA reductase is below the negative redox limit usually encountered in biological hydride transfer. Here, via X-ray crystallography and spectroscopic analysis, the authors elucidated the mechanism behind this.
format	article
author	Max Willistein Dominique F. Bechtel Christina S. Müller Ulrike Demmer Larissa Heimann Kanwal Kayastha Volker Schünemann Antonio J. Pierik G. Matthias Ullmann Ulrich Ermler Matthias Boll
author_facet	Max Willistein Dominique F. Bechtel Christina S. Müller Ulrike Demmer Larissa Heimann Kanwal Kayastha Volker Schünemann Antonio J. Pierik G. Matthias Ullmann Ulrich Ermler Matthias Boll
author_sort	Max Willistein
title	Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors
title_short	Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors
title_full	Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors
title_fullStr	Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors
title_full_unstemmed	Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors
title_sort	low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5384fcc9585141cc8574aa70b0d76cdc
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Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors

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