Temporal lobe activation during episodic memory encoding following traumatic brain injury

Abstract The temporal lobes are critical for encoding and retrieving episodic memories. The temporal lobes are preferentially disrupted following a traumatic brain injury (TBI), likely contributing to the difficulties observed in episodic memory. However, the underlying neural changes that precipita...

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Autores principales:	Abbie S. Taing, Matthew E. Mundy, Jennie L. Ponsford, Gershon Spitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5386d13849d34c8fa4388d228c743b74
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spelling	oai:doaj.org-article:5386d13849d34c8fa4388d228c743b742021-12-02T15:15:14ZTemporal lobe activation during episodic memory encoding following traumatic brain injury10.1038/s41598-021-97953-62045-2322https://doaj.org/article/5386d13849d34c8fa4388d228c743b742021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97953-6https://doaj.org/toc/2045-2322Abstract The temporal lobes are critical for encoding and retrieving episodic memories. The temporal lobes are preferentially disrupted following a traumatic brain injury (TBI), likely contributing to the difficulties observed in episodic memory. However, the underlying neural changes that precipitate or maintain these difficulties in individuals with TBI remains poorly understood. Here, we use functional magnetic resonance imaging (fMRI) to interrogate the relationship between temporal lobe activation and encoding of episodic stimuli. Participants encoded face, scene, and animal stimuli during an fMRI run. In an out-of-scanner task, participants were required to correctly identify previously displayed stimuli over two presentation runs (each in-scanner stimuli presented twice). Forty-three patients with moderate-severe TBI were recruited and compared with 38 demographically similar healthy controls. The pattern of behavioural performance between groups depended on the stimuli presentation run. The TBI group demonstrated poorer episodic memory for faces and scenes during the first presentation, but not the second presentation. When episodic memory was analysed across all presentation runs, behavioural deficits were only apparent for faces. Interestingly, processing of faces emerged as the only between group-difference on fMRI, whereby TBI participants had an increased signal in the middle temporal gyrus extending to the superior temporal sulcus. These findings provide evidence to suggest that following TBI: (a) episodic memory is preferentially impaired for complex stimuli such as faces, and (b) robust behavioural inefficiencies are reflected in increased activation in specific temporal lobe structures during encoding.Abbie S. TaingMatthew E. MundyJennie L. PonsfordGershon SpitzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abbie S. Taing Matthew E. Mundy Jennie L. Ponsford Gershon Spitz Temporal lobe activation during episodic memory encoding following traumatic brain injury
description	Abstract The temporal lobes are critical for encoding and retrieving episodic memories. The temporal lobes are preferentially disrupted following a traumatic brain injury (TBI), likely contributing to the difficulties observed in episodic memory. However, the underlying neural changes that precipitate or maintain these difficulties in individuals with TBI remains poorly understood. Here, we use functional magnetic resonance imaging (fMRI) to interrogate the relationship between temporal lobe activation and encoding of episodic stimuli. Participants encoded face, scene, and animal stimuli during an fMRI run. In an out-of-scanner task, participants were required to correctly identify previously displayed stimuli over two presentation runs (each in-scanner stimuli presented twice). Forty-three patients with moderate-severe TBI were recruited and compared with 38 demographically similar healthy controls. The pattern of behavioural performance between groups depended on the stimuli presentation run. The TBI group demonstrated poorer episodic memory for faces and scenes during the first presentation, but not the second presentation. When episodic memory was analysed across all presentation runs, behavioural deficits were only apparent for faces. Interestingly, processing of faces emerged as the only between group-difference on fMRI, whereby TBI participants had an increased signal in the middle temporal gyrus extending to the superior temporal sulcus. These findings provide evidence to suggest that following TBI: (a) episodic memory is preferentially impaired for complex stimuli such as faces, and (b) robust behavioural inefficiencies are reflected in increased activation in specific temporal lobe structures during encoding.
format	article
author	Abbie S. Taing Matthew E. Mundy Jennie L. Ponsford Gershon Spitz
author_facet	Abbie S. Taing Matthew E. Mundy Jennie L. Ponsford Gershon Spitz
author_sort	Abbie S. Taing
title	Temporal lobe activation during episodic memory encoding following traumatic brain injury
title_short	Temporal lobe activation during episodic memory encoding following traumatic brain injury
title_full	Temporal lobe activation during episodic memory encoding following traumatic brain injury
title_fullStr	Temporal lobe activation during episodic memory encoding following traumatic brain injury
title_full_unstemmed	Temporal lobe activation during episodic memory encoding following traumatic brain injury
title_sort	temporal lobe activation during episodic memory encoding following traumatic brain injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5386d13849d34c8fa4388d228c743b74
work_keys_str_mv	AT abbiestaing temporallobeactivationduringepisodicmemoryencodingfollowingtraumaticbraininjury AT matthewemundy temporallobeactivationduringepisodicmemoryencodingfollowingtraumaticbraininjury AT jennielponsford temporallobeactivationduringepisodicmemoryencodingfollowingtraumaticbraininjury AT gershonspitz temporallobeactivationduringepisodicmemoryencodingfollowingtraumaticbraininjury
_version_	1718387507427540992

Temporal lobe activation during episodic memory encoding following traumatic brain injury

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