Risks and prediction of postoperative hypoparathyroidism due to thyroid surgery

Abstract We aimed to investigate the prevalence of postoperative hypoparathyroidism (PoH), the relevant factors, and predictors of transient or permanent hypoparathyroidism. The files of 352 patients who underwent bilateral total thyroidectomy alone or with central lymph node dissection and/or later...

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Autores principales:	Mustafa Ömer Yazıcıoğlu, Abdurrezzak Yılmaz, Servet Kocaöz, Ruhşen Özçağlayan, Ömer Parlak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/53885baef9b5495793113a888b1e636e
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spelling	oai:doaj.org-article:53885baef9b5495793113a888b1e636e2021-12-02T15:57:12ZRisks and prediction of postoperative hypoparathyroidism due to thyroid surgery10.1038/s41598-021-91277-12045-2322https://doaj.org/article/53885baef9b5495793113a888b1e636e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91277-1https://doaj.org/toc/2045-2322Abstract We aimed to investigate the prevalence of postoperative hypoparathyroidism (PoH), the relevant factors, and predictors of transient or permanent hypoparathyroidism. The files of 352 patients who underwent bilateral total thyroidectomy alone or with central lymph node dissection and/or lateral neck dissection between June 1, 2019, and November 30, 2019, were retrospectively evaluated. Also, calcium and parathyroid hormone levels measured preoperatively and 4–6 h after surgery, follow-up examination results, and time to resolution of transient PoH were recorded. 16.48% (n = 58) of the surgical patients developed transient PoH and 3.98% (n = 14) developed permanent PoH. Length of hospital stay increased in patients who developed PoH (p < 0.001). Transient PoH developed less in patients who underwent parathyroid autotransplantation, while permanent PoH was not detected (p = 0.001). PoH development was not significantly correlated with nodule size as measured by preoperative thyroid ultrasonography (p = 0.944). Patients who had a serum PTH level ≤ 5.95 pmol/L 4–6 h after surgery had a greater risk of developing permanent PoH (OR 134.84, 95% CI 17.25–1053.82). PoH is more common in female gender and is not significantly correlated with nodule size. Parathyroid autotransplantation can prevent the development of PoH.Mustafa Ömer YazıcıoğluAbdurrezzak YılmazServet KocaözRuhşen ÖzçağlayanÖmer ParlakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mustafa Ömer Yazıcıoğlu Abdurrezzak Yılmaz Servet Kocaöz Ruhşen Özçağlayan Ömer Parlak Risks and prediction of postoperative hypoparathyroidism due to thyroid surgery
description	Abstract We aimed to investigate the prevalence of postoperative hypoparathyroidism (PoH), the relevant factors, and predictors of transient or permanent hypoparathyroidism. The files of 352 patients who underwent bilateral total thyroidectomy alone or with central lymph node dissection and/or lateral neck dissection between June 1, 2019, and November 30, 2019, were retrospectively evaluated. Also, calcium and parathyroid hormone levels measured preoperatively and 4–6 h after surgery, follow-up examination results, and time to resolution of transient PoH were recorded. 16.48% (n = 58) of the surgical patients developed transient PoH and 3.98% (n = 14) developed permanent PoH. Length of hospital stay increased in patients who developed PoH (p < 0.001). Transient PoH developed less in patients who underwent parathyroid autotransplantation, while permanent PoH was not detected (p = 0.001). PoH development was not significantly correlated with nodule size as measured by preoperative thyroid ultrasonography (p = 0.944). Patients who had a serum PTH level ≤ 5.95 pmol/L 4–6 h after surgery had a greater risk of developing permanent PoH (OR 134.84, 95% CI 17.25–1053.82). PoH is more common in female gender and is not significantly correlated with nodule size. Parathyroid autotransplantation can prevent the development of PoH.
format	article
author	Mustafa Ömer Yazıcıoğlu Abdurrezzak Yılmaz Servet Kocaöz Ruhşen Özçağlayan Ömer Parlak
author_facet	Mustafa Ömer Yazıcıoğlu Abdurrezzak Yılmaz Servet Kocaöz Ruhşen Özçağlayan Ömer Parlak
author_sort	Mustafa Ömer Yazıcıoğlu
title	Risks and prediction of postoperative hypoparathyroidism due to thyroid surgery
title_short	Risks and prediction of postoperative hypoparathyroidism due to thyroid surgery
title_full	Risks and prediction of postoperative hypoparathyroidism due to thyroid surgery
title_fullStr	Risks and prediction of postoperative hypoparathyroidism due to thyroid surgery
title_full_unstemmed	Risks and prediction of postoperative hypoparathyroidism due to thyroid surgery
title_sort	risks and prediction of postoperative hypoparathyroidism due to thyroid surgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/53885baef9b5495793113a888b1e636e
work_keys_str_mv	AT mustafaomeryazıcıoglu risksandpredictionofpostoperativehypoparathyroidismduetothyroidsurgery AT abdurrezzakyılmaz risksandpredictionofpostoperativehypoparathyroidismduetothyroidsurgery AT servetkocaoz risksandpredictionofpostoperativehypoparathyroidismduetothyroidsurgery AT ruhsenozcaglayan risksandpredictionofpostoperativehypoparathyroidismduetothyroidsurgery AT omerparlak risksandpredictionofpostoperativehypoparathyroidismduetothyroidsurgery
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Risks and prediction of postoperative hypoparathyroidism due to thyroid surgery

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