Characterization of rice bran wax policosanol and its nanoemulsion formulation

Aminu Ishaka,1,2 Mustapha Umar Imam,1 Rozi Mahamud,3 Abu Bakar Zakaria Zuki,4 Ismail Maznah1 1Laboratory of Molecular Biomedicine, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia; 2Department of Medical Biochemistry, College of Health Sciences, Usmanu Danfodiyo Unive...

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Autores principales:	Ishaka A, Umar Imam M, Mahamud R, Zuki ABZ, Maznah I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/53886cdc299d44eeb176b96e636ba43a
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spelling	oai:doaj.org-article:53886cdc299d44eeb176b96e636ba43a2021-12-02T03:11:38ZCharacterization of rice bran wax policosanol and its nanoemulsion formulation1178-2013https://doaj.org/article/53886cdc299d44eeb176b96e636ba43a2014-05-01T00:00:00Zhttp://www.dovepress.com/characterization-of-rice-bran-wax-policosanol-and-its-nanoemulsion-for-a16769https://doaj.org/toc/1178-2013 Aminu Ishaka,1,2 Mustapha Umar Imam,1 Rozi Mahamud,3 Abu Bakar Zakaria Zuki,4 Ismail Maznah1 1Laboratory of Molecular Biomedicine, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia; 2Department of Medical Biochemistry, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria; 3Faculty of Medicine and Health Sciences, 4Faculty of Veterinary Medicine, University Putra Malaysia, Serdang, Selangor, Malaysia Abstract: Policosanol, a mixture of long-chain alcohols found in animal and plant waxes, has several biological effects; however, it has a bioavailability of less than 10%. Therefore, there is a need to improve its bioavailability, and one of the ways of doing this is by nanoemulsion formulation. Different droplet size distributions are usually achieved when emulsions are formed, which solely depends on the preparation method used. Mostly, emulsions are intended for better delivery with maintenance of the characteristics and properties of the leading components. In this study, policosanol was extracted from rice bran wax, its composition was determined by gas chromatography mass spectrophotometry, nanoemulsion was made, and the physical stability characteristics were determined. The results showed that policosanol nanoemulsion has a nanosize particle distribution below 100 nm (92.56–94.52 nm), with optimum charge distribution (-55.8 to -45.12 mV), pH (6.79–6.92) and refractive index (1.50); these were monitored and found to be stable for 8 weeks. The stability of policosanol nanoemulsion confers the potential to withstand long storage times. Keywords: rice bran wax, policosanol, nanoemulsion, characterizationIshaka AUmar Imam MMahamud RZuki ABZMaznah IDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2261-2269 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ishaka A Umar Imam M Mahamud R Zuki ABZ Maznah I Characterization of rice bran wax policosanol and its nanoemulsion formulation
description	Aminu Ishaka,1,2 Mustapha Umar Imam,1 Rozi Mahamud,3 Abu Bakar Zakaria Zuki,4 Ismail Maznah1 1Laboratory of Molecular Biomedicine, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia; 2Department of Medical Biochemistry, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria; 3Faculty of Medicine and Health Sciences, 4Faculty of Veterinary Medicine, University Putra Malaysia, Serdang, Selangor, Malaysia Abstract: Policosanol, a mixture of long-chain alcohols found in animal and plant waxes, has several biological effects; however, it has a bioavailability of less than 10%. Therefore, there is a need to improve its bioavailability, and one of the ways of doing this is by nanoemulsion formulation. Different droplet size distributions are usually achieved when emulsions are formed, which solely depends on the preparation method used. Mostly, emulsions are intended for better delivery with maintenance of the characteristics and properties of the leading components. In this study, policosanol was extracted from rice bran wax, its composition was determined by gas chromatography mass spectrophotometry, nanoemulsion was made, and the physical stability characteristics were determined. The results showed that policosanol nanoemulsion has a nanosize particle distribution below 100 nm (92.56–94.52 nm), with optimum charge distribution (-55.8 to -45.12 mV), pH (6.79–6.92) and refractive index (1.50); these were monitored and found to be stable for 8 weeks. The stability of policosanol nanoemulsion confers the potential to withstand long storage times. Keywords: rice bran wax, policosanol, nanoemulsion, characterization
format	article
author	Ishaka A Umar Imam M Mahamud R Zuki ABZ Maznah I
author_facet	Ishaka A Umar Imam M Mahamud R Zuki ABZ Maznah I
author_sort	Ishaka A
title	Characterization of rice bran wax policosanol and its nanoemulsion formulation
title_short	Characterization of rice bran wax policosanol and its nanoemulsion formulation
title_full	Characterization of rice bran wax policosanol and its nanoemulsion formulation
title_fullStr	Characterization of rice bran wax policosanol and its nanoemulsion formulation
title_full_unstemmed	Characterization of rice bran wax policosanol and its nanoemulsion formulation
title_sort	characterization of rice bran wax policosanol and its nanoemulsion formulation
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/53886cdc299d44eeb176b96e636ba43a
work_keys_str_mv	AT ishakaa characterizationofricebranwaxpolicosanolanditsnanoemulsionformulation AT umarimamm characterizationofricebranwaxpolicosanolanditsnanoemulsionformulation AT mahamudr characterizationofricebranwaxpolicosanolanditsnanoemulsionformulation AT zukiabz characterizationofricebranwaxpolicosanolanditsnanoemulsionformulation AT maznahi characterizationofricebranwaxpolicosanolanditsnanoemulsionformulation
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Characterization of rice bran wax policosanol and its nanoemulsion formulation

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