BMPRIA mediated signaling is essential for temporomandibular joint development in mice.

The central importance of BMP signaling in the development and homeostasis of synovial joint of appendicular skeleton has been well documented, but its role in the development of temporomandibular joint (TMJ), also classified as a synovial joint, remains completely unknown. In this study, we investi...

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Autores principales:	Shuping Gu, Weijie Wu, Chao Liu, Ling Yang, Cheng Sun, Wenduo Ye, Xihai Li, Jianquan Chen, Fanxin Long, YiPing Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5389132bda6647f7b0100e9542548b71
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spelling	oai:doaj.org-article:5389132bda6647f7b0100e9542548b712021-11-25T06:06:01ZBMPRIA mediated signaling is essential for temporomandibular joint development in mice.1932-620310.1371/journal.pone.0101000https://doaj.org/article/5389132bda6647f7b0100e9542548b712014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25093411/?tool=EBIhttps://doaj.org/toc/1932-6203The central importance of BMP signaling in the development and homeostasis of synovial joint of appendicular skeleton has been well documented, but its role in the development of temporomandibular joint (TMJ), also classified as a synovial joint, remains completely unknown. In this study, we investigated the function of BMPRIA mediated signaling in TMJ development in mice by transgenic loss-of- and gain-of-function approaches. We found that BMPRIA is expressed in the cranial neural crest (CNC)-derived developing condyle and glenoid fossa, major components of TMJ, as well as the interzone mesenchymal cells. Wnt1-Cre mediated tissue specific inactivation of BmprIa in CNC lineage led to defective TMJ development, including failure of articular disc separation from a hypoplastic condyle, persistence of interzone cells, and failed formation of a functional fibrocartilage layer on the articular surface of the glenoid fossa and condyle, which could be at least partially attributed to the down-regulation of Ihh in the developing condyle and inhibition of apoptosis in the interzone. On the other hand, augmented BMPRIA signaling by Wnt1-Cre driven expression of a constitutively active form of BmprIa (caBmprIa) inhibited osteogenesis of the glenoid fossa and converted the condylar primordium from secondary cartilage to primary cartilage associated with ectopic activation of Smad-dependent pathway but inhibition of JNK pathway, leading to TMJ agenesis. Our results present unambiguous evidence for an essential role of finely tuned BMPRIA mediated signaling in TMJ development.Shuping GuWeijie WuChao LiuLing YangCheng SunWenduo YeXihai LiJianquan ChenFanxin LongYiPing ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e101000 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuping Gu Weijie Wu Chao Liu Ling Yang Cheng Sun Wenduo Ye Xihai Li Jianquan Chen Fanxin Long YiPing Chen BMPRIA mediated signaling is essential for temporomandibular joint development in mice.
description	The central importance of BMP signaling in the development and homeostasis of synovial joint of appendicular skeleton has been well documented, but its role in the development of temporomandibular joint (TMJ), also classified as a synovial joint, remains completely unknown. In this study, we investigated the function of BMPRIA mediated signaling in TMJ development in mice by transgenic loss-of- and gain-of-function approaches. We found that BMPRIA is expressed in the cranial neural crest (CNC)-derived developing condyle and glenoid fossa, major components of TMJ, as well as the interzone mesenchymal cells. Wnt1-Cre mediated tissue specific inactivation of BmprIa in CNC lineage led to defective TMJ development, including failure of articular disc separation from a hypoplastic condyle, persistence of interzone cells, and failed formation of a functional fibrocartilage layer on the articular surface of the glenoid fossa and condyle, which could be at least partially attributed to the down-regulation of Ihh in the developing condyle and inhibition of apoptosis in the interzone. On the other hand, augmented BMPRIA signaling by Wnt1-Cre driven expression of a constitutively active form of BmprIa (caBmprIa) inhibited osteogenesis of the glenoid fossa and converted the condylar primordium from secondary cartilage to primary cartilage associated with ectopic activation of Smad-dependent pathway but inhibition of JNK pathway, leading to TMJ agenesis. Our results present unambiguous evidence for an essential role of finely tuned BMPRIA mediated signaling in TMJ development.
format	article
author	Shuping Gu Weijie Wu Chao Liu Ling Yang Cheng Sun Wenduo Ye Xihai Li Jianquan Chen Fanxin Long YiPing Chen
author_facet	Shuping Gu Weijie Wu Chao Liu Ling Yang Cheng Sun Wenduo Ye Xihai Li Jianquan Chen Fanxin Long YiPing Chen
author_sort	Shuping Gu
title	BMPRIA mediated signaling is essential for temporomandibular joint development in mice.
title_short	BMPRIA mediated signaling is essential for temporomandibular joint development in mice.
title_full	BMPRIA mediated signaling is essential for temporomandibular joint development in mice.
title_fullStr	BMPRIA mediated signaling is essential for temporomandibular joint development in mice.
title_full_unstemmed	BMPRIA mediated signaling is essential for temporomandibular joint development in mice.
title_sort	bmpria mediated signaling is essential for temporomandibular joint development in mice.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5389132bda6647f7b0100e9542548b71
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BMPRIA mediated signaling is essential for temporomandibular joint development in mice.

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