Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor

The helical transmembrane segments of membrane proteins play central roles in sensory transduction but the mechanistic basis for their function remains unresolved. Here the authors identify regions in the S4 voltage-sensing segment of Shaker potassium channels where local helical structure is relian...

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Autores principales:	Daniel T. Infield, Kimberly Matulef, Jason D. Galpin, Kin Lam, Emad Tajkhorshid, Christopher A. Ahern, Francis I. Valiyaveetil
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5389ce9f78e749c898ea82cd26136909
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spelling	oai:doaj.org-article:5389ce9f78e749c898ea82cd261369092021-12-02T16:49:53ZMain-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor10.1038/s41467-018-07477-32041-1723https://doaj.org/article/5389ce9f78e749c898ea82cd261369092018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07477-3https://doaj.org/toc/2041-1723The helical transmembrane segments of membrane proteins play central roles in sensory transduction but the mechanistic basis for their function remains unresolved. Here the authors identify regions in the S4 voltage-sensing segment of Shaker potassium channels where local helical structure is reliant upon backbone amide support.Daniel T. InfieldKimberly MatulefJason D. GalpinKin LamEmad TajkhorshidChristopher A. AhernFrancis I. ValiyaveetilNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel T. Infield Kimberly Matulef Jason D. Galpin Kin Lam Emad Tajkhorshid Christopher A. Ahern Francis I. Valiyaveetil Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor
description	The helical transmembrane segments of membrane proteins play central roles in sensory transduction but the mechanistic basis for their function remains unresolved. Here the authors identify regions in the S4 voltage-sensing segment of Shaker potassium channels where local helical structure is reliant upon backbone amide support.
format	article
author	Daniel T. Infield Kimberly Matulef Jason D. Galpin Kin Lam Emad Tajkhorshid Christopher A. Ahern Francis I. Valiyaveetil
author_facet	Daniel T. Infield Kimberly Matulef Jason D. Galpin Kin Lam Emad Tajkhorshid Christopher A. Ahern Francis I. Valiyaveetil
author_sort	Daniel T. Infield
title	Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor
title_short	Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor
title_full	Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor
title_fullStr	Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor
title_full_unstemmed	Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor
title_sort	main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5389ce9f78e749c898ea82cd26136909
work_keys_str_mv	AT danieltinfield mainchainmutagenesisrevealsintrahelicalcouplinginanionchannelvoltagesensor AT kimberlymatulef mainchainmutagenesisrevealsintrahelicalcouplinginanionchannelvoltagesensor AT jasondgalpin mainchainmutagenesisrevealsintrahelicalcouplinginanionchannelvoltagesensor AT kinlam mainchainmutagenesisrevealsintrahelicalcouplinginanionchannelvoltagesensor AT emadtajkhorshid mainchainmutagenesisrevealsintrahelicalcouplinginanionchannelvoltagesensor AT christopheraahern mainchainmutagenesisrevealsintrahelicalcouplinginanionchannelvoltagesensor AT francisivaliyaveetil mainchainmutagenesisrevealsintrahelicalcouplinginanionchannelvoltagesensor
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Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor

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