Epidemiology of tuberculosis in an urban slum of Dhaka City, Bangladesh.

<h4>Background</h4>The objectives of this study were to assess the tuberculosis (TB) burden and to provide an insight into the type of circulating M. tuberculosis species in urban slums of Bangladesh. We also aimed to test the feasibility of a larger transmission study in this setting.&l...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sayera Banu, Md Toufiq Rahman, Mohammad Khaja Mafij Uddin, Razia Khatun, Tahmeed Ahmed, Md Mojibur Rahman, Md Ashaque Husain, Frank van Leth
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/538f3b47b68f42a39a43c97ba0d41672
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:538f3b47b68f42a39a43c97ba0d41672
record_format	dspace
spelling	oai:doaj.org-article:538f3b47b68f42a39a43c97ba0d416722021-11-18T08:50:11ZEpidemiology of tuberculosis in an urban slum of Dhaka City, Bangladesh.1932-620310.1371/journal.pone.0077721https://doaj.org/article/538f3b47b68f42a39a43c97ba0d416722013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24204933/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The objectives of this study were to assess the tuberculosis (TB) burden and to provide an insight into the type of circulating M. tuberculosis species in urban slums of Bangladesh. We also aimed to test the feasibility of a larger transmission study in this setting.<h4>Methods</h4>This cross-sectional study was conducted in an urban slum of Dhaka city. The household members were actively screened to assess the presence of TB-related signs and symptoms; cough ≥ 3 weeks and body mass index (BMI) <17 kg/m(2). Sputum specimens from suspects were collected for acid fast bacilli (AFB) microscopy, culture and drug susceptibility testing. Genotyping of M. tuberculosis was done using spoligotyping and variable number tandem repeats of mycobacterial interspersed repetitive units typing.<h4>Results</h4>Among 9,877 adult screened for pulmonary TB (PTB), 25 were positive for AFB on microscopy and/or culture and the prevalence of new PTB cases was estimated to be 253/100,000. Only one child TB case was diagnosed among 5,147 child screened. Out of 26 cases, 21(81%) had cough for several duration and 5(19%) did not present with cough at the time of screening. One multidrug resistant case was found. Fifty two percent of all TB cases had BMI <17 kg/m2 (p = <0.001). Among the 20 analyzed isolates, 13 different spoligotype patterns were identified in which 5 clusters contained 12 strains and 8 strains had unique pattern.<h4>Conclusions</h4>The study revealed high prevalence of TB in urban slums. Screening using low BMI can be beneficial among risk group population. It is important to conduct larger study to validate clinical variables like cough <3 weeks and low BMI to define TB suspect and also to investigate the transmission of TB in slum settings.Sayera BanuMd Toufiq RahmanMohammad Khaja Mafij UddinRazia KhatunTahmeed AhmedMd Mojibur RahmanMd Ashaque HusainFrank van LethPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e77721 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sayera Banu Md Toufiq Rahman Mohammad Khaja Mafij Uddin Razia Khatun Tahmeed Ahmed Md Mojibur Rahman Md Ashaque Husain Frank van Leth Epidemiology of tuberculosis in an urban slum of Dhaka City, Bangladesh.
description	<h4>Background</h4>The objectives of this study were to assess the tuberculosis (TB) burden and to provide an insight into the type of circulating M. tuberculosis species in urban slums of Bangladesh. We also aimed to test the feasibility of a larger transmission study in this setting.<h4>Methods</h4>This cross-sectional study was conducted in an urban slum of Dhaka city. The household members were actively screened to assess the presence of TB-related signs and symptoms; cough ≥ 3 weeks and body mass index (BMI) <17 kg/m(2). Sputum specimens from suspects were collected for acid fast bacilli (AFB) microscopy, culture and drug susceptibility testing. Genotyping of M. tuberculosis was done using spoligotyping and variable number tandem repeats of mycobacterial interspersed repetitive units typing.<h4>Results</h4>Among 9,877 adult screened for pulmonary TB (PTB), 25 were positive for AFB on microscopy and/or culture and the prevalence of new PTB cases was estimated to be 253/100,000. Only one child TB case was diagnosed among 5,147 child screened. Out of 26 cases, 21(81%) had cough for several duration and 5(19%) did not present with cough at the time of screening. One multidrug resistant case was found. Fifty two percent of all TB cases had BMI <17 kg/m2 (p = <0.001). Among the 20 analyzed isolates, 13 different spoligotype patterns were identified in which 5 clusters contained 12 strains and 8 strains had unique pattern.<h4>Conclusions</h4>The study revealed high prevalence of TB in urban slums. Screening using low BMI can be beneficial among risk group population. It is important to conduct larger study to validate clinical variables like cough <3 weeks and low BMI to define TB suspect and also to investigate the transmission of TB in slum settings.
format	article
author	Sayera Banu Md Toufiq Rahman Mohammad Khaja Mafij Uddin Razia Khatun Tahmeed Ahmed Md Mojibur Rahman Md Ashaque Husain Frank van Leth
author_facet	Sayera Banu Md Toufiq Rahman Mohammad Khaja Mafij Uddin Razia Khatun Tahmeed Ahmed Md Mojibur Rahman Md Ashaque Husain Frank van Leth
author_sort	Sayera Banu
title	Epidemiology of tuberculosis in an urban slum of Dhaka City, Bangladesh.
title_short	Epidemiology of tuberculosis in an urban slum of Dhaka City, Bangladesh.
title_full	Epidemiology of tuberculosis in an urban slum of Dhaka City, Bangladesh.
title_fullStr	Epidemiology of tuberculosis in an urban slum of Dhaka City, Bangladesh.
title_full_unstemmed	Epidemiology of tuberculosis in an urban slum of Dhaka City, Bangladesh.
title_sort	epidemiology of tuberculosis in an urban slum of dhaka city, bangladesh.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/538f3b47b68f42a39a43c97ba0d41672
work_keys_str_mv	AT sayerabanu epidemiologyoftuberculosisinanurbanslumofdhakacitybangladesh AT mdtoufiqrahman epidemiologyoftuberculosisinanurbanslumofdhakacitybangladesh AT mohammadkhajamafijuddin epidemiologyoftuberculosisinanurbanslumofdhakacitybangladesh AT raziakhatun epidemiologyoftuberculosisinanurbanslumofdhakacitybangladesh AT tahmeedahmed epidemiologyoftuberculosisinanurbanslumofdhakacitybangladesh AT mdmojiburrahman epidemiologyoftuberculosisinanurbanslumofdhakacitybangladesh AT mdashaquehusain epidemiologyoftuberculosisinanurbanslumofdhakacitybangladesh AT frankvanleth epidemiologyoftuberculosisinanurbanslumofdhakacitybangladesh
_version_	1718421261419282432

Epidemiology of tuberculosis in an urban slum of Dhaka City, Bangladesh.

Ejemplares similares