Long-Term Cardiac Sequelae in Patients Referred into a Diagnostic Post-COVID-19 Pathway: The Different Impacts on the Right and Left Ventricles

Most patients who had COVID-19 are still symptomatic after many months post infection, but the long-term outcomes are not yet well defined. The aim of our prospective/retrospective study was to define the cardiac sequelae of COVID-19 infection. This monocentric cohort study included 160 consecutive...

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Autores principales:	Giovanna Pelà, Matteo Goldoni, Chiara Cavalli, Felice Perrino, Sara Tagliaferri, Annalisa Frizzelli, Pier Anselmo Mori, Maria Majori, Marina Aiello, Nicola Sverzellati, Massimo Corradi, Alfredo Chetta
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 long-COVID-19 cardiac involvement echocardiography pulmonary hypertension biventricular dysfunction Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/53956edadb6a44b2a0f6c51c3a4c7394
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spelling	oai:doaj.org-article:53956edadb6a44b2a0f6c51c3a4c73942021-11-25T17:21:15ZLong-Term Cardiac Sequelae in Patients Referred into a Diagnostic Post-COVID-19 Pathway: The Different Impacts on the Right and Left Ventricles10.3390/diagnostics111120592075-4418https://doaj.org/article/53956edadb6a44b2a0f6c51c3a4c73942021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2059https://doaj.org/toc/2075-4418Most patients who had COVID-19 are still symptomatic after many months post infection, but the long-term outcomes are not yet well defined. The aim of our prospective/retrospective study was to define the cardiac sequelae of COVID-19 infection. This monocentric cohort study included 160 consecutive patients who had been discharged from the ward or from the outpatient clinic after a diagnosis of COVID-19 and subsequently referred for a follow-up visit. Clinical features’ data about the acute phase along with information about the follow-up visit, including ECG and Echocardiographic parameters, were recorded. At an average follow-up of 5 months, echocardiography showed morpho-functional characteristics of both right (RV) and left (LV) ventricles, such as RV dilation, increased pressure in the pulmonary circulation, and bi-ventricular systolic–diastolic dysfunction. When examined using multivariate analysis, independent of age, sex, and co-morbidities, RV and LV changes were significantly associated with chest High-Resolution computed tomography score and hemodynamic Instability (HI), and with C-reactive protein, respectively. Our results suggest that COVID-19 may impact RV and LV differently. Notably, the extent of the pneumonia and HI may affect RV, whereas the inflammatory status may influence LV. A long-term follow-up is warranted to refine and customize the most appropriate therapeutic strategies.Giovanna PelàMatteo GoldoniChiara CavalliFelice PerrinoSara TagliaferriAnnalisa FrizzelliPier Anselmo MoriMaria MajoriMarina AielloNicola SverzellatiMassimo CorradiAlfredo ChettaMDPI AGarticleSARS-CoV-2long-COVID-19cardiac involvementechocardiographypulmonary hypertensionbiventricular dysfunctionMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2059, p 2059 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 long-COVID-19 cardiac involvement echocardiography pulmonary hypertension biventricular dysfunction Medicine (General) R5-920
spellingShingle	SARS-CoV-2 long-COVID-19 cardiac involvement echocardiography pulmonary hypertension biventricular dysfunction Medicine (General) R5-920 Giovanna Pelà Matteo Goldoni Chiara Cavalli Felice Perrino Sara Tagliaferri Annalisa Frizzelli Pier Anselmo Mori Maria Majori Marina Aiello Nicola Sverzellati Massimo Corradi Alfredo Chetta Long-Term Cardiac Sequelae in Patients Referred into a Diagnostic Post-COVID-19 Pathway: The Different Impacts on the Right and Left Ventricles
description	Most patients who had COVID-19 are still symptomatic after many months post infection, but the long-term outcomes are not yet well defined. The aim of our prospective/retrospective study was to define the cardiac sequelae of COVID-19 infection. This monocentric cohort study included 160 consecutive patients who had been discharged from the ward or from the outpatient clinic after a diagnosis of COVID-19 and subsequently referred for a follow-up visit. Clinical features’ data about the acute phase along with information about the follow-up visit, including ECG and Echocardiographic parameters, were recorded. At an average follow-up of 5 months, echocardiography showed morpho-functional characteristics of both right (RV) and left (LV) ventricles, such as RV dilation, increased pressure in the pulmonary circulation, and bi-ventricular systolic–diastolic dysfunction. When examined using multivariate analysis, independent of age, sex, and co-morbidities, RV and LV changes were significantly associated with chest High-Resolution computed tomography score and hemodynamic Instability (HI), and with C-reactive protein, respectively. Our results suggest that COVID-19 may impact RV and LV differently. Notably, the extent of the pneumonia and HI may affect RV, whereas the inflammatory status may influence LV. A long-term follow-up is warranted to refine and customize the most appropriate therapeutic strategies.
format	article
author	Giovanna Pelà Matteo Goldoni Chiara Cavalli Felice Perrino Sara Tagliaferri Annalisa Frizzelli Pier Anselmo Mori Maria Majori Marina Aiello Nicola Sverzellati Massimo Corradi Alfredo Chetta
author_facet	Giovanna Pelà Matteo Goldoni Chiara Cavalli Felice Perrino Sara Tagliaferri Annalisa Frizzelli Pier Anselmo Mori Maria Majori Marina Aiello Nicola Sverzellati Massimo Corradi Alfredo Chetta
author_sort	Giovanna Pelà
title	Long-Term Cardiac Sequelae in Patients Referred into a Diagnostic Post-COVID-19 Pathway: The Different Impacts on the Right and Left Ventricles
title_short	Long-Term Cardiac Sequelae in Patients Referred into a Diagnostic Post-COVID-19 Pathway: The Different Impacts on the Right and Left Ventricles
title_full	Long-Term Cardiac Sequelae in Patients Referred into a Diagnostic Post-COVID-19 Pathway: The Different Impacts on the Right and Left Ventricles
title_fullStr	Long-Term Cardiac Sequelae in Patients Referred into a Diagnostic Post-COVID-19 Pathway: The Different Impacts on the Right and Left Ventricles
title_full_unstemmed	Long-Term Cardiac Sequelae in Patients Referred into a Diagnostic Post-COVID-19 Pathway: The Different Impacts on the Right and Left Ventricles
title_sort	long-term cardiac sequelae in patients referred into a diagnostic post-covid-19 pathway: the different impacts on the right and left ventricles
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/53956edadb6a44b2a0f6c51c3a4c7394
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Long-Term Cardiac Sequelae in Patients Referred into a Diagnostic Post-COVID-19 Pathway: The Different Impacts on the Right and Left Ventricles

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