Cardioprotective effects of Cu(II)ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1

Cardioprotective effects of Cu(II)ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1

Abstract Cu(II)ATSM was developed as a hypoxia sensitive positron emission tomography agent. Recent reports have highlighted the neuroprotective properties of Cu(II)ATSM, yet there are no reports that it confers cardioprotection. We demonstrate that Cu(II)ATSM activates the redox-sensitive transcrip...

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Autores principales: Salil Srivastava, Philip J. Blower, Aisah A. Aubdool, Robert C. Hider, Giovanni E. Mann, Richard C. Siow
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/539979e057014d39ad5ec5aeb895f034
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