Cardioprotective effects of Cu(II)ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1

Abstract Cu(II)ATSM was developed as a hypoxia sensitive positron emission tomography agent. Recent reports have highlighted the neuroprotective properties of Cu(II)ATSM, yet there are no reports that it confers cardioprotection. We demonstrate that Cu(II)ATSM activates the redox-sensitive transcrip...

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Bibliographic Details
Main Authors: Salil Srivastava, Philip J. Blower, Aisah A. Aubdool, Robert C. Hider, Giovanni E. Mann, Richard C. Siow
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
R
Q
Online Access:https://doaj.org/article/539979e057014d39ad5ec5aeb895f034
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