Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area

Abstract The integration and utilization of feedback in order to determine which decision strategy to use in different contexts is the core of executive function. The anterior cingulate cortex (ACC) is central to these processes but how feedback is made available to the ACC is unclear. To address th...

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Autores principales:	Thomas W. Elston, Shivam Kalhan, David K. Bilkey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/539c5d8936fc4abbb33409d80462428c
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spelling	oai:doaj.org-article:539c5d8936fc4abbb33409d80462428c2021-12-02T15:09:04ZConflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area10.1038/s41598-018-30203-42045-2322https://doaj.org/article/539c5d8936fc4abbb33409d80462428c2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30203-4https://doaj.org/toc/2045-2322Abstract The integration and utilization of feedback in order to determine which decision strategy to use in different contexts is the core of executive function. The anterior cingulate cortex (ACC) is central to these processes but how feedback is made available to the ACC is unclear. To address this question, we trained rats with implants in the ACC and the ventral tegmental area (VTA), a dopaminergic brain region implicated in feedback processing, in a spatial decision reversal task with rule switching occurring approximately every 12 trials. Following a rule switch, the rats had to shift and sustain responses to the alternative side in order to obtain reward. Partial directed coherence (PDC) models of signal directionality between the ACC and VTA indicated that VTA → ACC communication (near 4 Hz) increased immediately prior to incorrect choices and during post-error decisions. This increase did not occur during correct choices. These data indicate that the VTA provides a feedback-driven, bottom-up modulating signal to the ACC which may be involved in assessing, and correcting for, decision conflict.Thomas W. ElstonShivam KalhanDavid K. BilkeyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas W. Elston Shivam Kalhan David K. Bilkey Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
description	Abstract The integration and utilization of feedback in order to determine which decision strategy to use in different contexts is the core of executive function. The anterior cingulate cortex (ACC) is central to these processes but how feedback is made available to the ACC is unclear. To address this question, we trained rats with implants in the ACC and the ventral tegmental area (VTA), a dopaminergic brain region implicated in feedback processing, in a spatial decision reversal task with rule switching occurring approximately every 12 trials. Following a rule switch, the rats had to shift and sustain responses to the alternative side in order to obtain reward. Partial directed coherence (PDC) models of signal directionality between the ACC and VTA indicated that VTA → ACC communication (near 4 Hz) increased immediately prior to incorrect choices and during post-error decisions. This increase did not occur during correct choices. These data indicate that the VTA provides a feedback-driven, bottom-up modulating signal to the ACC which may be involved in assessing, and correcting for, decision conflict.
format	article
author	Thomas W. Elston Shivam Kalhan David K. Bilkey
author_facet	Thomas W. Elston Shivam Kalhan David K. Bilkey
author_sort	Thomas W. Elston
title	Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
title_short	Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
title_full	Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
title_fullStr	Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
title_full_unstemmed	Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
title_sort	conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/539c5d8936fc4abbb33409d80462428c
work_keys_str_mv	AT thomaswelston conflictandadaptationsignalsintheanteriorcingulatecortexandventraltegmentalarea AT shivamkalhan conflictandadaptationsignalsintheanteriorcingulatecortexandventraltegmentalarea AT davidkbilkey conflictandadaptationsignalsintheanteriorcingulatecortexandventraltegmentalarea
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Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area

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