Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy

Abstract The objective of this study was to examine the impact of around-the-clock (ATC) administration of intravenous (IV) acetaminophen following robot-assisted radical prostatectomy (RARP). Intravenous infusion of acetaminophen was started on the day of the operation at 1000 mg/dose every 6 h, an...

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Autores principales:	Shogo Inoue, Hirotsugu Miyoshi, Keisuke Hieda, Tetsutaro Hayashi, Yasuo M. Tsutsumi, Jun Teishima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/539cda83d25849a0aa0c7dc0c38cea63
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spelling	oai:doaj.org-article:539cda83d25849a0aa0c7dc0c38cea632021-12-02T13:33:50ZPostoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy10.1038/s41598-021-84866-72045-2322https://doaj.org/article/539cda83d25849a0aa0c7dc0c38cea632021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84866-7https://doaj.org/toc/2045-2322Abstract The objective of this study was to examine the impact of around-the-clock (ATC) administration of intravenous (IV) acetaminophen following robot-assisted radical prostatectomy (RARP). Intravenous infusion of acetaminophen was started on the day of the operation at 1000 mg/dose every 6 h, and the infusion was continued on a fixed schedule until postoperative day 2 a.m. In a retrospective observational study, we compared 127 patients who were administered IV acetaminophen on a fixed schedule (ATC group) with 485 patients who were administered analgesic drugs only as needed (PRN group). We investigated postoperative pain intensity and additional analgesic consumption on postoperative day 0, 1, 2, 3, and 5 between the two groups. Postoperative pain scores were significantly lower in the ATC group than in the PRN group at 1 and 2 days, and this period matched the duration of ATC administration of IV acetaminophen. Postoperative frequency of rescue analgesia was significantly lower in the ATC group than in the PRN group at postoperative 0, 1, and 2 days. ATC administration of IV acetaminophen has the potential to be a very versatile and valuable additional dose to achieve appropriate postoperative analgesia in patients with RARP.Shogo InoueHirotsugu MiyoshiKeisuke HiedaTetsutaro HayashiYasuo M. TsutsumiJun TeishimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shogo Inoue Hirotsugu Miyoshi Keisuke Hieda Tetsutaro Hayashi Yasuo M. Tsutsumi Jun Teishima Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy
description	Abstract The objective of this study was to examine the impact of around-the-clock (ATC) administration of intravenous (IV) acetaminophen following robot-assisted radical prostatectomy (RARP). Intravenous infusion of acetaminophen was started on the day of the operation at 1000 mg/dose every 6 h, and the infusion was continued on a fixed schedule until postoperative day 2 a.m. In a retrospective observational study, we compared 127 patients who were administered IV acetaminophen on a fixed schedule (ATC group) with 485 patients who were administered analgesic drugs only as needed (PRN group). We investigated postoperative pain intensity and additional analgesic consumption on postoperative day 0, 1, 2, 3, and 5 between the two groups. Postoperative pain scores were significantly lower in the ATC group than in the PRN group at 1 and 2 days, and this period matched the duration of ATC administration of IV acetaminophen. Postoperative frequency of rescue analgesia was significantly lower in the ATC group than in the PRN group at postoperative 0, 1, and 2 days. ATC administration of IV acetaminophen has the potential to be a very versatile and valuable additional dose to achieve appropriate postoperative analgesia in patients with RARP.
format	article
author	Shogo Inoue Hirotsugu Miyoshi Keisuke Hieda Tetsutaro Hayashi Yasuo M. Tsutsumi Jun Teishima
author_facet	Shogo Inoue Hirotsugu Miyoshi Keisuke Hieda Tetsutaro Hayashi Yasuo M. Tsutsumi Jun Teishima
author_sort	Shogo Inoue
title	Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy
title_short	Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy
title_full	Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy
title_fullStr	Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy
title_full_unstemmed	Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy
title_sort	postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/539cda83d25849a0aa0c7dc0c38cea63
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Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy

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