MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis

Abstract The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol phosphate (MEP) pathway of isoprenoi...

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Main Authors: Rachel L. Edwards, Robert C. Brothers, Xu Wang, Maxim I. Maron, Peter D. Ziniel, Patricia S. Tsang, Thomas E. Kraft, Paul W. Hruz, Kim C. Williamson, Cynthia S. Dowd, Audrey R. Odom John
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/539d6d0aabfc46c68f5a489b64e29fac
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https://doaj.org/article/539d6d0aabfc46c68f5a489b64e29fac

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