Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study

Ping Zhang,1,* Ying-Xue Li,1,* Zhe-Zhe Zhang,2 Ye Yang,1 Ji-Xian Rao,1 Lan Xia,3 Xue-Yan Li,1 Gui-Hai Chen,1 Fang Wang2 1Department of Sleep Disorders, The Affiliated Chaohu Hospital of Anhui Medical University, Hefei 238000, People’s Republic of China; 2Department of Neurology, The First...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhang P, Li YX, Zhang ZZ, Yang Y, Rao JX, Xia L, Li XY, Chen GH, Wang F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cognition s100 calcium binding protein b glial fibrillary acidic protein brain-derived neurotrophic factor glial cell line-derived neurotrophic factor Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/53a5c6dda25445478d571b0c5fb21710
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:53a5c6dda25445478d571b0c5fb21710
record_format	dspace
spelling	oai:doaj.org-article:53a5c6dda25445478d571b0c5fb217102021-12-02T11:21:12ZAstroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study1179-1608https://doaj.org/article/53a5c6dda25445478d571b0c5fb217102020-10-01T00:00:00Zhttps://www.dovepress.com/astroglial-mechanisms-underlying-chronic-insomnia-disorder-a-clinical--peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Ping Zhang,1,* Ying-Xue Li,1,* Zhe-Zhe Zhang,2 Ye Yang,1 Ji-Xian Rao,1 Lan Xia,3 Xue-Yan Li,1 Gui-Hai Chen,1 Fang Wang2 1Department of Sleep Disorders, The Affiliated Chaohu Hospital of Anhui Medical University, Hefei 238000, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of China; 3Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fang WangDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of ChinaTel/Fax +86-551-62922426Email doctorwangfang2006@163.comGui-Hai ChenDepartment of Sleep Disorders, The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, (Chaohu) 238000, People’s Republic of ChinaTel/Fax +86-551-82324252Email doctorcgh@163.comPurpose: The objective of this study was to investigate whether the serum biomarkers S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) change in patients with chronic insomnia disorder (CID), and if this is the case, whether the altered levels of these serum biomarkers are associated with poor sleep quality and cognitive decline in CID.Patients and Methods: Fifty-seven CID outpatients constituted the CID group; thirty healthy controls (HC) were also enrolled. Questionnaires, polysomnography, Chinese-Beijing Version of Montreal Cognitive Assessment (MoCA-C) and Nine Box Maze Test (NBMT) were used to assess their sleep and neuropsychological function. Serum S100B, GFAP, BDNF, and GDNF were evaluated using enzyme-linked immunosorbent assay.Results: The CID group had higher levels of S100B and GFAP and lower levels of BDNF and GDNF than the HC group. Spearman correlation analysis revealed that poor sleep quality, assessed by subjective and objective measures, was positively correlated with S100B level and negatively correlated with BDNF level. GFAP level correlated positively with poor subjective sleep quality. Moreover, S100B and GFAP levels correlated negatively with general cognitive function assessed using MoCA-C. GFAP level correlated positively with poor spatial working memory (SWM) in the NBMT; BDNF level was linked to poor SWM and object recognition memory (ORcM) in the NBMT. However, principal component analysis revealed that serum S100B level was positively linked to the errors in object working memories, BDNF and GDNF concentrations were negatively linked with errors in ORcM, and GFAP concentration was positively correlated with the errors in the SWM and spatial reference memories.Conclusion: Serum S100B, GFAP, BDNF, and GDNF levels were altered in patients with CID, indicating astrocyte damage, and were associated with insomnia severity or/and cognitive dysfunction.Keywords: cognition, S100 calcium binding protein B, glial fibrillary acidic protein, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factorZhang PLi YXZhang ZZYang YRao JXXia LLi XYChen GHWang FDove Medical Pressarticlecognitions100 calcium binding protein bglial fibrillary acidic proteinbrain-derived neurotrophic factorglial cell line-derived neurotrophic factorPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 693-704 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognition s100 calcium binding protein b glial fibrillary acidic protein brain-derived neurotrophic factor glial cell line-derived neurotrophic factor Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	cognition s100 calcium binding protein b glial fibrillary acidic protein brain-derived neurotrophic factor glial cell line-derived neurotrophic factor Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Zhang P Li YX Zhang ZZ Yang Y Rao JX Xia L Li XY Chen GH Wang F Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study
description	Ping Zhang,1,* Ying-Xue Li,1,* Zhe-Zhe Zhang,2 Ye Yang,1 Ji-Xian Rao,1 Lan Xia,3 Xue-Yan Li,1 Gui-Hai Chen,1 Fang Wang2 1Department of Sleep Disorders, The Affiliated Chaohu Hospital of Anhui Medical University, Hefei 238000, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of China; 3Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fang WangDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of ChinaTel/Fax +86-551-62922426Email doctorwangfang2006@163.comGui-Hai ChenDepartment of Sleep Disorders, The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, (Chaohu) 238000, People’s Republic of ChinaTel/Fax +86-551-82324252Email doctorcgh@163.comPurpose: The objective of this study was to investigate whether the serum biomarkers S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) change in patients with chronic insomnia disorder (CID), and if this is the case, whether the altered levels of these serum biomarkers are associated with poor sleep quality and cognitive decline in CID.Patients and Methods: Fifty-seven CID outpatients constituted the CID group; thirty healthy controls (HC) were also enrolled. Questionnaires, polysomnography, Chinese-Beijing Version of Montreal Cognitive Assessment (MoCA-C) and Nine Box Maze Test (NBMT) were used to assess their sleep and neuropsychological function. Serum S100B, GFAP, BDNF, and GDNF were evaluated using enzyme-linked immunosorbent assay.Results: The CID group had higher levels of S100B and GFAP and lower levels of BDNF and GDNF than the HC group. Spearman correlation analysis revealed that poor sleep quality, assessed by subjective and objective measures, was positively correlated with S100B level and negatively correlated with BDNF level. GFAP level correlated positively with poor subjective sleep quality. Moreover, S100B and GFAP levels correlated negatively with general cognitive function assessed using MoCA-C. GFAP level correlated positively with poor spatial working memory (SWM) in the NBMT; BDNF level was linked to poor SWM and object recognition memory (ORcM) in the NBMT. However, principal component analysis revealed that serum S100B level was positively linked to the errors in object working memories, BDNF and GDNF concentrations were negatively linked with errors in ORcM, and GFAP concentration was positively correlated with the errors in the SWM and spatial reference memories.Conclusion: Serum S100B, GFAP, BDNF, and GDNF levels were altered in patients with CID, indicating astrocyte damage, and were associated with insomnia severity or/and cognitive dysfunction.Keywords: cognition, S100 calcium binding protein B, glial fibrillary acidic protein, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor
format	article
author	Zhang P Li YX Zhang ZZ Yang Y Rao JX Xia L Li XY Chen GH Wang F
author_facet	Zhang P Li YX Zhang ZZ Yang Y Rao JX Xia L Li XY Chen GH Wang F
author_sort	Zhang P
title	Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study
title_short	Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study
title_full	Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study
title_fullStr	Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study
title_full_unstemmed	Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study
title_sort	astroglial mechanisms underlying chronic insomnia disorder: a clinical study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/53a5c6dda25445478d571b0c5fb21710
work_keys_str_mv	AT zhangp astroglialmechanismsunderlyingchronicinsomniadisorderaclinicalstudy AT liyx astroglialmechanismsunderlyingchronicinsomniadisorderaclinicalstudy AT zhangzz astroglialmechanismsunderlyingchronicinsomniadisorderaclinicalstudy AT yangy astroglialmechanismsunderlyingchronicinsomniadisorderaclinicalstudy AT raojx astroglialmechanismsunderlyingchronicinsomniadisorderaclinicalstudy AT xial astroglialmechanismsunderlyingchronicinsomniadisorderaclinicalstudy AT lixy astroglialmechanismsunderlyingchronicinsomniadisorderaclinicalstudy AT chengh astroglialmechanismsunderlyingchronicinsomniadisorderaclinicalstudy AT wangf astroglialmechanismsunderlyingchronicinsomniadisorderaclinicalstudy
_version_	1718395990579347456

Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study

Ejemplares similares