Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics

Abstract Hamstring muscle injury is highly prevalent in sports involving repeated maximal sprinting. Although neuromuscular fatigue is thought to be a risk factor, the mechanisms underlying the fatigue response to repeated maximal sprints are unclear. Here, we show that repeated maximal sprints indu...

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Autores principales:	Philipp Baumert, S. Temple, J. M. Stanley, M. Cocks, J. A. Strauss, S. O. Shepherd, B. Drust, M. J. Lake, C. E. Stewart, R. M. Erskine
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/53a68bf164044438bd2a38ee26221cef
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spelling	oai:doaj.org-article:53a68bf164044438bd2a38ee26221cef2021-12-02T14:37:39ZNeuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics10.1038/s41598-021-87195-x2045-2322https://doaj.org/article/53a68bf164044438bd2a38ee26221cef2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87195-xhttps://doaj.org/toc/2045-2322Abstract Hamstring muscle injury is highly prevalent in sports involving repeated maximal sprinting. Although neuromuscular fatigue is thought to be a risk factor, the mechanisms underlying the fatigue response to repeated maximal sprints are unclear. Here, we show that repeated maximal sprints induce neuromuscular fatigue accompanied with a prolonged strength loss in hamstring muscles. The immediate hamstring strength loss was linked to both central and peripheral fatigue, while prolonged strength loss was associated with indicators of muscle damage. The kinematic changes immediately after sprinting likely protected fatigued hamstrings from excess elongation stress, while larger hamstring muscle physiological cross-sectional area and lower myoblast:fibroblast ratio appeared to protect against fatigue/damage and improve muscle recovery within the first 48 h after sprinting. We have therefore identified novel mechanisms that likely regulate the fatigue/damage response and initial recovery following repeated maximal sprinting in humans.Philipp BaumertS. TempleJ. M. StanleyM. CocksJ. A. StraussS. O. ShepherdB. DrustM. J. LakeC. E. StewartR. M. ErskineNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philipp Baumert S. Temple J. M. Stanley M. Cocks J. A. Strauss S. O. Shepherd B. Drust M. J. Lake C. E. Stewart R. M. Erskine Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics
description	Abstract Hamstring muscle injury is highly prevalent in sports involving repeated maximal sprinting. Although neuromuscular fatigue is thought to be a risk factor, the mechanisms underlying the fatigue response to repeated maximal sprints are unclear. Here, we show that repeated maximal sprints induce neuromuscular fatigue accompanied with a prolonged strength loss in hamstring muscles. The immediate hamstring strength loss was linked to both central and peripheral fatigue, while prolonged strength loss was associated with indicators of muscle damage. The kinematic changes immediately after sprinting likely protected fatigued hamstrings from excess elongation stress, while larger hamstring muscle physiological cross-sectional area and lower myoblast:fibroblast ratio appeared to protect against fatigue/damage and improve muscle recovery within the first 48 h after sprinting. We have therefore identified novel mechanisms that likely regulate the fatigue/damage response and initial recovery following repeated maximal sprinting in humans.
format	article
author	Philipp Baumert S. Temple J. M. Stanley M. Cocks J. A. Strauss S. O. Shepherd B. Drust M. J. Lake C. E. Stewart R. M. Erskine
author_facet	Philipp Baumert S. Temple J. M. Stanley M. Cocks J. A. Strauss S. O. Shepherd B. Drust M. J. Lake C. E. Stewart R. M. Erskine
author_sort	Philipp Baumert
title	Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics
title_short	Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics
title_full	Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics
title_fullStr	Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics
title_full_unstemmed	Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics
title_sort	neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/53a68bf164044438bd2a38ee26221cef
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Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics

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