The long non-coding RNA LOC441204 enhances cell growth in human glioma

Abstract Glioma is the most common and aggressive type of brain tumor. While long non-coding RNAs (lncRNAs) are clearly more abundant in human brain than protein-coding genes, the specific roles of lncRNAs and mechanisms underlying their dysregulation in glioma remain unclear. Here, we focused on ln...

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Autores principales:	Tzu-Kang Lin, Chang-Nen Chang, Cheng-Shian Tsai, Yin-Cheng Huang, Yu-Jen Lu, Wei-Jan Chen, Yang-Hsiang Lin, I.-Hsiao Chung, Kwang-Huei Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/53a7a8248e354d14bde510ecaf27bf7a
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spelling	oai:doaj.org-article:53a7a8248e354d14bde510ecaf27bf7a2021-12-02T12:31:51ZThe long non-coding RNA LOC441204 enhances cell growth in human glioma10.1038/s41598-017-05688-02045-2322https://doaj.org/article/53a7a8248e354d14bde510ecaf27bf7a2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05688-0https://doaj.org/toc/2045-2322Abstract Glioma is the most common and aggressive type of brain tumor. While long non-coding RNAs (lncRNAs) are clearly more abundant in human brain than protein-coding genes, the specific roles of lncRNAs and mechanisms underlying their dysregulation in glioma remain unclear. Here, we focused on lncRNAs that are differentially expressed in brain tumor and their potential biological functions. LOC441204, a novel non-coding RNA gene displaying high expression in clinical specimens of brain tumor and significant upregulation in glioma cell lines in microarray analyses, was selected for further study. Notably, knockdown of LOC441204 suppressed tumor cell proliferation in two glioma cell lines. Moreover, LOC441204-induced tumor cell growth was mediated the stabilization of β-catenin pathway. Briefly, LOC441204 bound to β-catenin preventing its degradation, resulting in downstream p21 repression and cdk4 activation to enhance glioma cell proliferation. Collectively, our findings indicate a pro-oncogenic role of LOC441204 in tumor cell growth through activation of the β-catenin/p21/cdk4 cascade to act as a potential diagnostic marker or therapeutic target in brain tumor.Tzu-Kang LinChang-Nen ChangCheng-Shian TsaiYin-Cheng HuangYu-Jen LuWei-Jan ChenYang-Hsiang LinI.-Hsiao ChungKwang-Huei LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tzu-Kang Lin Chang-Nen Chang Cheng-Shian Tsai Yin-Cheng Huang Yu-Jen Lu Wei-Jan Chen Yang-Hsiang Lin I.-Hsiao Chung Kwang-Huei Lin The long non-coding RNA LOC441204 enhances cell growth in human glioma
description	Abstract Glioma is the most common and aggressive type of brain tumor. While long non-coding RNAs (lncRNAs) are clearly more abundant in human brain than protein-coding genes, the specific roles of lncRNAs and mechanisms underlying their dysregulation in glioma remain unclear. Here, we focused on lncRNAs that are differentially expressed in brain tumor and their potential biological functions. LOC441204, a novel non-coding RNA gene displaying high expression in clinical specimens of brain tumor and significant upregulation in glioma cell lines in microarray analyses, was selected for further study. Notably, knockdown of LOC441204 suppressed tumor cell proliferation in two glioma cell lines. Moreover, LOC441204-induced tumor cell growth was mediated the stabilization of β-catenin pathway. Briefly, LOC441204 bound to β-catenin preventing its degradation, resulting in downstream p21 repression and cdk4 activation to enhance glioma cell proliferation. Collectively, our findings indicate a pro-oncogenic role of LOC441204 in tumor cell growth through activation of the β-catenin/p21/cdk4 cascade to act as a potential diagnostic marker or therapeutic target in brain tumor.
format	article
author	Tzu-Kang Lin Chang-Nen Chang Cheng-Shian Tsai Yin-Cheng Huang Yu-Jen Lu Wei-Jan Chen Yang-Hsiang Lin I.-Hsiao Chung Kwang-Huei Lin
author_facet	Tzu-Kang Lin Chang-Nen Chang Cheng-Shian Tsai Yin-Cheng Huang Yu-Jen Lu Wei-Jan Chen Yang-Hsiang Lin I.-Hsiao Chung Kwang-Huei Lin
author_sort	Tzu-Kang Lin
title	The long non-coding RNA LOC441204 enhances cell growth in human glioma
title_short	The long non-coding RNA LOC441204 enhances cell growth in human glioma
title_full	The long non-coding RNA LOC441204 enhances cell growth in human glioma
title_fullStr	The long non-coding RNA LOC441204 enhances cell growth in human glioma
title_full_unstemmed	The long non-coding RNA LOC441204 enhances cell growth in human glioma
title_sort	long non-coding rna loc441204 enhances cell growth in human glioma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/53a7a8248e354d14bde510ecaf27bf7a
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The long non-coding RNA LOC441204 enhances cell growth in human glioma

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