BRAFV600E induces reversible mitotic arrest in human melanocytes via microrna-mediated suppression of AURKB

Benign melanocytic nevi frequently emerge when an acquired BRAFV600E mutation triggers unchecked proliferation and subsequent arrest in melanocytes. Recent observations have challenged the role of oncogene-induced senescence in melanocytic nevus formation, necessitating investigations into alternati...

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Autores principales:	Andrew S McNeal, Rachel L Belote, Hanlin Zeng, Marcus Urquijo, Kendra Barker, Rodrigo Torres, Meghan Curtin, A Hunter Shain, Robert HI Andtbacka, Sheri Holmen, David H Lum, Timothy H McCalmont, Matt W VanBrocklin, Douglas Grossman, Maria L Wei, Ursula E Lang, Robert L Judson-Torres
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	melanoma melanocytes nevi microRNA Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/53ad9d885af34b1391f8b61352342926
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BRAFV600E induces reversible mitotic arrest in human melanocytes via microrna-mediated suppression of AURKB

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