Intraoperative pH Is a Reliable Prognostic Factor for Patients With Periampullary Carcinoma Undergoing Pancreaticoduodenectomy

A reliable prognostic factor for periampullary carcinoma is critical to improve surgical outcomes. Intraoperative acidosis reflects the incidence of intraoperative adverse events and impact the prognosis. In this study, 612 patients with periampullary carcinoma who underwent pancreaticoduodenectomy...

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Autores principales:	Chao Dang, Min Wang, Tingmei Wang, Renyi Qin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pancreaticoduodenectomy pancreatic cancer pH prognostic factor weakly alkaline Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/53aede6fbba2427fb565707cd9c1cf44
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spelling	oai:doaj.org-article:53aede6fbba2427fb565707cd9c1cf442021-11-05T08:35:58ZIntraoperative pH Is a Reliable Prognostic Factor for Patients With Periampullary Carcinoma Undergoing Pancreaticoduodenectomy2234-943X10.3389/fonc.2021.764572https://doaj.org/article/53aede6fbba2427fb565707cd9c1cf442021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.764572/fullhttps://doaj.org/toc/2234-943XA reliable prognostic factor for periampullary carcinoma is critical to improve surgical outcomes. Intraoperative acidosis reflects the incidence of intraoperative adverse events and impact the prognosis. In this study, 612 patients with periampullary carcinoma who underwent pancreaticoduodenectomy (PD) were divided into high- and low-pH groups according to the cut-off value of receiver operating characteristic curve (7.34). Through statistical analysis of the difference between the high- and low-pH group, it was found that the low-pH group had worse short-term prognosis than the high pH group, and intraoperative pH was an independent prognostic factor for patients with periampullary carcinoma undergoing PD. In addition, patients who underwent laparoscopic pancreaticoduodenectomy had a more alkaline pH after surgery. This is of great help for early judgment of short-term and even long-term prognosis of patients with pancreatic cancer after surgery, and can even guide clinicians to improve prognosis by early adjustment of pH value.Chao DangMin WangTingmei WangRenyi QinFrontiers Media S.A.articlepancreaticoduodenectomypancreatic cancerpHprognostic factorweakly alkalineNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancreaticoduodenectomy pancreatic cancer pH prognostic factor weakly alkaline Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	pancreaticoduodenectomy pancreatic cancer pH prognostic factor weakly alkaline Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chao Dang Min Wang Tingmei Wang Renyi Qin Intraoperative pH Is a Reliable Prognostic Factor for Patients With Periampullary Carcinoma Undergoing Pancreaticoduodenectomy
description	A reliable prognostic factor for periampullary carcinoma is critical to improve surgical outcomes. Intraoperative acidosis reflects the incidence of intraoperative adverse events and impact the prognosis. In this study, 612 patients with periampullary carcinoma who underwent pancreaticoduodenectomy (PD) were divided into high- and low-pH groups according to the cut-off value of receiver operating characteristic curve (7.34). Through statistical analysis of the difference between the high- and low-pH group, it was found that the low-pH group had worse short-term prognosis than the high pH group, and intraoperative pH was an independent prognostic factor for patients with periampullary carcinoma undergoing PD. In addition, patients who underwent laparoscopic pancreaticoduodenectomy had a more alkaline pH after surgery. This is of great help for early judgment of short-term and even long-term prognosis of patients with pancreatic cancer after surgery, and can even guide clinicians to improve prognosis by early adjustment of pH value.
format	article
author	Chao Dang Min Wang Tingmei Wang Renyi Qin
author_facet	Chao Dang Min Wang Tingmei Wang Renyi Qin
author_sort	Chao Dang
title	Intraoperative pH Is a Reliable Prognostic Factor for Patients With Periampullary Carcinoma Undergoing Pancreaticoduodenectomy
title_short	Intraoperative pH Is a Reliable Prognostic Factor for Patients With Periampullary Carcinoma Undergoing Pancreaticoduodenectomy
title_full	Intraoperative pH Is a Reliable Prognostic Factor for Patients With Periampullary Carcinoma Undergoing Pancreaticoduodenectomy
title_fullStr	Intraoperative pH Is a Reliable Prognostic Factor for Patients With Periampullary Carcinoma Undergoing Pancreaticoduodenectomy
title_full_unstemmed	Intraoperative pH Is a Reliable Prognostic Factor for Patients With Periampullary Carcinoma Undergoing Pancreaticoduodenectomy
title_sort	intraoperative ph is a reliable prognostic factor for patients with periampullary carcinoma undergoing pancreaticoduodenectomy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/53aede6fbba2427fb565707cd9c1cf44
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_version_	1718444468976222208

Intraoperative pH Is a Reliable Prognostic Factor for Patients With Periampullary Carcinoma Undergoing Pancreaticoduodenectomy

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