Heterogeneous recruitment abilities to RNA polymerases generate nonlinear scaling of gene expression with cell volume

Expression levels of most genes are proportional to cell volumes, although some genes exhibit nonlinear scaling of expression levels with cell volume. Here the authors provide a model that reveals nonlinear scaling is a direct consequence of heterogeneous recruitment abilities of promoters to RNA po...

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Detalles Bibliográficos
Autores principales:	Qirun Wang, Jie Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53b1ccbbbf18473abbb782fb64bd2c74
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spelling	oai:doaj.org-article:53b1ccbbbf18473abbb782fb64bd2c742021-11-28T12:32:24ZHeterogeneous recruitment abilities to RNA polymerases generate nonlinear scaling of gene expression with cell volume10.1038/s41467-021-26952-y2041-1723https://doaj.org/article/53b1ccbbbf18473abbb782fb64bd2c742021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26952-yhttps://doaj.org/toc/2041-1723Expression levels of most genes are proportional to cell volumes, although some genes exhibit nonlinear scaling of expression levels with cell volume. Here the authors provide a model that reveals nonlinear scaling is a direct consequence of heterogeneous recruitment abilities of promoters to RNA polymerases.Qirun WangJie LinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qirun Wang Jie Lin Heterogeneous recruitment abilities to RNA polymerases generate nonlinear scaling of gene expression with cell volume
description	Expression levels of most genes are proportional to cell volumes, although some genes exhibit nonlinear scaling of expression levels with cell volume. Here the authors provide a model that reveals nonlinear scaling is a direct consequence of heterogeneous recruitment abilities of promoters to RNA polymerases.
format	article
author	Qirun Wang Jie Lin
author_facet	Qirun Wang Jie Lin
author_sort	Qirun Wang
title	Heterogeneous recruitment abilities to RNA polymerases generate nonlinear scaling of gene expression with cell volume
title_short	Heterogeneous recruitment abilities to RNA polymerases generate nonlinear scaling of gene expression with cell volume
title_full	Heterogeneous recruitment abilities to RNA polymerases generate nonlinear scaling of gene expression with cell volume
title_fullStr	Heterogeneous recruitment abilities to RNA polymerases generate nonlinear scaling of gene expression with cell volume
title_full_unstemmed	Heterogeneous recruitment abilities to RNA polymerases generate nonlinear scaling of gene expression with cell volume
title_sort	heterogeneous recruitment abilities to rna polymerases generate nonlinear scaling of gene expression with cell volume
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/53b1ccbbbf18473abbb782fb64bd2c74
work_keys_str_mv	AT qirunwang heterogeneousrecruitmentabilitiestornapolymerasesgeneratenonlinearscalingofgeneexpressionwithcellvolume AT jielin heterogeneousrecruitmentabilitiestornapolymerasesgeneratenonlinearscalingofgeneexpressionwithcellvolume
_version_	1718407889955061760

Heterogeneous recruitment abilities to RNA polymerases generate nonlinear scaling of gene expression with cell volume

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