Cryo-EM structure of human Wntless in complex with Wnt3a

The transmembrane protein Wntless (WLS) is essential for the secretion of Wnt proteins, which are signaling molecules of the Wnt signaling pathways. Here, the authors present the 2.2 Å cryo-EM structure of human WLS in complex with Wnt3a and discuss mechanistic implications for the palmitoleoylation...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Qing Zhong, Yanyu Zhao, Fangfei Ye, Zaiyu Xiao, Gaoxingyu Huang, Meng Xu, Yuanyuan Zhang, Xiechao Zhan, Ke Sun, Zhizhi Wang, Shanshan Cheng, Shan Feng, Xiuxiu Zhao, Jizhong Zhang, Peilong Lu, Wenqing Xu, Qiang Zhou, Dan Ma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/53b7470a0afd4e14a3d033ca7b13b669
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:53b7470a0afd4e14a3d033ca7b13b669
record_format dspace
spelling oai:doaj.org-article:53b7470a0afd4e14a3d033ca7b13b6692021-12-02T18:46:58ZCryo-EM structure of human Wntless in complex with Wnt3a10.1038/s41467-021-24731-32041-1723https://doaj.org/article/53b7470a0afd4e14a3d033ca7b13b6692021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24731-3https://doaj.org/toc/2041-1723The transmembrane protein Wntless (WLS) is essential for the secretion of Wnt proteins, which are signaling molecules of the Wnt signaling pathways. Here, the authors present the 2.2 Å cryo-EM structure of human WLS in complex with Wnt3a and discuss mechanistic implications for the palmitoleoylation of Wnt3a that is required for WLS mediated Wnt secretion.Qing ZhongYanyu ZhaoFangfei YeZaiyu XiaoGaoxingyu HuangMeng XuYuanyuan ZhangXiechao ZhanKe SunZhizhi WangShanshan ChengShan FengXiuxiu ZhaoJizhong ZhangPeilong LuWenqing XuQiang ZhouDan MaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qing Zhong
Yanyu Zhao
Fangfei Ye
Zaiyu Xiao
Gaoxingyu Huang
Meng Xu
Yuanyuan Zhang
Xiechao Zhan
Ke Sun
Zhizhi Wang
Shanshan Cheng
Shan Feng
Xiuxiu Zhao
Jizhong Zhang
Peilong Lu
Wenqing Xu
Qiang Zhou
Dan Ma
Cryo-EM structure of human Wntless in complex with Wnt3a
description The transmembrane protein Wntless (WLS) is essential for the secretion of Wnt proteins, which are signaling molecules of the Wnt signaling pathways. Here, the authors present the 2.2 Å cryo-EM structure of human WLS in complex with Wnt3a and discuss mechanistic implications for the palmitoleoylation of Wnt3a that is required for WLS mediated Wnt secretion.
format article
author Qing Zhong
Yanyu Zhao
Fangfei Ye
Zaiyu Xiao
Gaoxingyu Huang
Meng Xu
Yuanyuan Zhang
Xiechao Zhan
Ke Sun
Zhizhi Wang
Shanshan Cheng
Shan Feng
Xiuxiu Zhao
Jizhong Zhang
Peilong Lu
Wenqing Xu
Qiang Zhou
Dan Ma
author_facet Qing Zhong
Yanyu Zhao
Fangfei Ye
Zaiyu Xiao
Gaoxingyu Huang
Meng Xu
Yuanyuan Zhang
Xiechao Zhan
Ke Sun
Zhizhi Wang
Shanshan Cheng
Shan Feng
Xiuxiu Zhao
Jizhong Zhang
Peilong Lu
Wenqing Xu
Qiang Zhou
Dan Ma
author_sort Qing Zhong
title Cryo-EM structure of human Wntless in complex with Wnt3a
title_short Cryo-EM structure of human Wntless in complex with Wnt3a
title_full Cryo-EM structure of human Wntless in complex with Wnt3a
title_fullStr Cryo-EM structure of human Wntless in complex with Wnt3a
title_full_unstemmed Cryo-EM structure of human Wntless in complex with Wnt3a
title_sort cryo-em structure of human wntless in complex with wnt3a
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/53b7470a0afd4e14a3d033ca7b13b669
work_keys_str_mv AT qingzhong cryoemstructureofhumanwntlessincomplexwithwnt3a
AT yanyuzhao cryoemstructureofhumanwntlessincomplexwithwnt3a
AT fangfeiye cryoemstructureofhumanwntlessincomplexwithwnt3a
AT zaiyuxiao cryoemstructureofhumanwntlessincomplexwithwnt3a
AT gaoxingyuhuang cryoemstructureofhumanwntlessincomplexwithwnt3a
AT mengxu cryoemstructureofhumanwntlessincomplexwithwnt3a
AT yuanyuanzhang cryoemstructureofhumanwntlessincomplexwithwnt3a
AT xiechaozhan cryoemstructureofhumanwntlessincomplexwithwnt3a
AT kesun cryoemstructureofhumanwntlessincomplexwithwnt3a
AT zhizhiwang cryoemstructureofhumanwntlessincomplexwithwnt3a
AT shanshancheng cryoemstructureofhumanwntlessincomplexwithwnt3a
AT shanfeng cryoemstructureofhumanwntlessincomplexwithwnt3a
AT xiuxiuzhao cryoemstructureofhumanwntlessincomplexwithwnt3a
AT jizhongzhang cryoemstructureofhumanwntlessincomplexwithwnt3a
AT peilonglu cryoemstructureofhumanwntlessincomplexwithwnt3a
AT wenqingxu cryoemstructureofhumanwntlessincomplexwithwnt3a
AT qiangzhou cryoemstructureofhumanwntlessincomplexwithwnt3a
AT danma cryoemstructureofhumanwntlessincomplexwithwnt3a
_version_ 1718377680691265536