Cryo-EM structure of human Wntless in complex with Wnt3a

The transmembrane protein Wntless (WLS) is essential for the secretion of Wnt proteins, which are signaling molecules of the Wnt signaling pathways. Here, the authors present the 2.2 Å cryo-EM structure of human WLS in complex with Wnt3a and discuss mechanistic implications for the palmitoleoylation...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Qing Zhong, Yanyu Zhao, Fangfei Ye, Zaiyu Xiao, Gaoxingyu Huang, Meng Xu, Yuanyuan Zhang, Xiechao Zhan, Ke Sun, Zhizhi Wang, Shanshan Cheng, Shan Feng, Xiuxiu Zhao, Jizhong Zhang, Peilong Lu, Wenqing Xu, Qiang Zhou, Dan Ma
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/53b7470a0afd4e14a3d033ca7b13b669
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:53b7470a0afd4e14a3d033ca7b13b669
record_format	dspace
spelling	oai:doaj.org-article:53b7470a0afd4e14a3d033ca7b13b6692021-12-02T18:46:58ZCryo-EM structure of human Wntless in complex with Wnt3a10.1038/s41467-021-24731-32041-1723https://doaj.org/article/53b7470a0afd4e14a3d033ca7b13b6692021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24731-3https://doaj.org/toc/2041-1723The transmembrane protein Wntless (WLS) is essential for the secretion of Wnt proteins, which are signaling molecules of the Wnt signaling pathways. Here, the authors present the 2.2 Å cryo-EM structure of human WLS in complex with Wnt3a and discuss mechanistic implications for the palmitoleoylation of Wnt3a that is required for WLS mediated Wnt secretion.Qing ZhongYanyu ZhaoFangfei YeZaiyu XiaoGaoxingyu HuangMeng XuYuanyuan ZhangXiechao ZhanKe SunZhizhi WangShanshan ChengShan FengXiuxiu ZhaoJizhong ZhangPeilong LuWenqing XuQiang ZhouDan MaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qing Zhong Yanyu Zhao Fangfei Ye Zaiyu Xiao Gaoxingyu Huang Meng Xu Yuanyuan Zhang Xiechao Zhan Ke Sun Zhizhi Wang Shanshan Cheng Shan Feng Xiuxiu Zhao Jizhong Zhang Peilong Lu Wenqing Xu Qiang Zhou Dan Ma Cryo-EM structure of human Wntless in complex with Wnt3a
description	The transmembrane protein Wntless (WLS) is essential for the secretion of Wnt proteins, which are signaling molecules of the Wnt signaling pathways. Here, the authors present the 2.2 Å cryo-EM structure of human WLS in complex with Wnt3a and discuss mechanistic implications for the palmitoleoylation of Wnt3a that is required for WLS mediated Wnt secretion.
format	article
author	Qing Zhong Yanyu Zhao Fangfei Ye Zaiyu Xiao Gaoxingyu Huang Meng Xu Yuanyuan Zhang Xiechao Zhan Ke Sun Zhizhi Wang Shanshan Cheng Shan Feng Xiuxiu Zhao Jizhong Zhang Peilong Lu Wenqing Xu Qiang Zhou Dan Ma
author_facet	Qing Zhong Yanyu Zhao Fangfei Ye Zaiyu Xiao Gaoxingyu Huang Meng Xu Yuanyuan Zhang Xiechao Zhan Ke Sun Zhizhi Wang Shanshan Cheng Shan Feng Xiuxiu Zhao Jizhong Zhang Peilong Lu Wenqing Xu Qiang Zhou Dan Ma
author_sort	Qing Zhong
title	Cryo-EM structure of human Wntless in complex with Wnt3a
title_short	Cryo-EM structure of human Wntless in complex with Wnt3a
title_full	Cryo-EM structure of human Wntless in complex with Wnt3a
title_fullStr	Cryo-EM structure of human Wntless in complex with Wnt3a
title_full_unstemmed	Cryo-EM structure of human Wntless in complex with Wnt3a
title_sort	cryo-em structure of human wntless in complex with wnt3a
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/53b7470a0afd4e14a3d033ca7b13b669
work_keys_str_mv	AT qingzhong cryoemstructureofhumanwntlessincomplexwithwnt3a AT yanyuzhao cryoemstructureofhumanwntlessincomplexwithwnt3a AT fangfeiye cryoemstructureofhumanwntlessincomplexwithwnt3a AT zaiyuxiao cryoemstructureofhumanwntlessincomplexwithwnt3a AT gaoxingyuhuang cryoemstructureofhumanwntlessincomplexwithwnt3a AT mengxu cryoemstructureofhumanwntlessincomplexwithwnt3a AT yuanyuanzhang cryoemstructureofhumanwntlessincomplexwithwnt3a AT xiechaozhan cryoemstructureofhumanwntlessincomplexwithwnt3a AT kesun cryoemstructureofhumanwntlessincomplexwithwnt3a AT zhizhiwang cryoemstructureofhumanwntlessincomplexwithwnt3a AT shanshancheng cryoemstructureofhumanwntlessincomplexwithwnt3a AT shanfeng cryoemstructureofhumanwntlessincomplexwithwnt3a AT xiuxiuzhao cryoemstructureofhumanwntlessincomplexwithwnt3a AT jizhongzhang cryoemstructureofhumanwntlessincomplexwithwnt3a AT peilonglu cryoemstructureofhumanwntlessincomplexwithwnt3a AT wenqingxu cryoemstructureofhumanwntlessincomplexwithwnt3a AT qiangzhou cryoemstructureofhumanwntlessincomplexwithwnt3a AT danma cryoemstructureofhumanwntlessincomplexwithwnt3a
_version_	1718377680691265536

Cryo-EM structure of human Wntless in complex with Wnt3a

Documents similaires