Predicting the Outcome of Infectious Diseases: Variability among Inbred Mice as a New and Powerful Tool for Biomarker Discovery

ABSTRACT Individuals respond differently to infectious diseases. Even among inbred mice that are presumed to be genetically identical, the response to a microbial pathogen is variable, which is generally thought to reflect experimental inconsistencies, technical errors, and stochastic processes. Her...

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Autores principales:	Miriam E. Martin, Jacquelyn A. Dieter, Zheng Luo, Nicole Baumgarth, Jay V. Solnick
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2012
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/53ba82784805479fa7341e3c9c3ca665
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spelling	oai:doaj.org-article:53ba82784805479fa7341e3c9c3ca6652021-11-15T15:39:13ZPredicting the Outcome of Infectious Diseases: Variability among Inbred Mice as a New and Powerful Tool for Biomarker Discovery10.1128/mBio.00199-122150-7511https://doaj.org/article/53ba82784805479fa7341e3c9c3ca6652012-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00199-12https://doaj.org/toc/2150-7511ABSTRACT Individuals respond differently to infectious diseases. Even among inbred mice that are presumed to be genetically identical, the response to a microbial pathogen is variable, which is generally thought to reflect experimental inconsistencies, technical errors, and stochastic processes. Here we describe the remarkable observation that the variability of Helicobacter pylori colonization density in the stomachs of experimentally infected C57BL/6J mice is tightly correlated with weight loss and viral load after a challenge with influenza virus, though H. pylori infection per se does not affect influenza and vice versa. Since these two infectious agents are found in different tissue compartments and are detected using unrelated methods, the correlation in microbial burden must represent a biological measure of disease susceptibility among genetically nearly identical individuals and not technical or stochastic factors. We hypothesize that inbred mice represent a powerful new tool for the identification of biomarkers to predict the outcome of infectious diseases.Miriam E. MartinJacquelyn A. DieterZheng LuoNicole BaumgarthJay V. SolnickAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 5 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Miriam E. Martin Jacquelyn A. Dieter Zheng Luo Nicole Baumgarth Jay V. Solnick Predicting the Outcome of Infectious Diseases: Variability among Inbred Mice as a New and Powerful Tool for Biomarker Discovery
description	ABSTRACT Individuals respond differently to infectious diseases. Even among inbred mice that are presumed to be genetically identical, the response to a microbial pathogen is variable, which is generally thought to reflect experimental inconsistencies, technical errors, and stochastic processes. Here we describe the remarkable observation that the variability of Helicobacter pylori colonization density in the stomachs of experimentally infected C57BL/6J mice is tightly correlated with weight loss and viral load after a challenge with influenza virus, though H. pylori infection per se does not affect influenza and vice versa. Since these two infectious agents are found in different tissue compartments and are detected using unrelated methods, the correlation in microbial burden must represent a biological measure of disease susceptibility among genetically nearly identical individuals and not technical or stochastic factors. We hypothesize that inbred mice represent a powerful new tool for the identification of biomarkers to predict the outcome of infectious diseases.
format	article
author	Miriam E. Martin Jacquelyn A. Dieter Zheng Luo Nicole Baumgarth Jay V. Solnick
author_facet	Miriam E. Martin Jacquelyn A. Dieter Zheng Luo Nicole Baumgarth Jay V. Solnick
author_sort	Miriam E. Martin
title	Predicting the Outcome of Infectious Diseases: Variability among Inbred Mice as a New and Powerful Tool for Biomarker Discovery
title_short	Predicting the Outcome of Infectious Diseases: Variability among Inbred Mice as a New and Powerful Tool for Biomarker Discovery
title_full	Predicting the Outcome of Infectious Diseases: Variability among Inbred Mice as a New and Powerful Tool for Biomarker Discovery
title_fullStr	Predicting the Outcome of Infectious Diseases: Variability among Inbred Mice as a New and Powerful Tool for Biomarker Discovery
title_full_unstemmed	Predicting the Outcome of Infectious Diseases: Variability among Inbred Mice as a New and Powerful Tool for Biomarker Discovery
title_sort	predicting the outcome of infectious diseases: variability among inbred mice as a new and powerful tool for biomarker discovery
publisher	American Society for Microbiology
publishDate	2012
url	https://doaj.org/article/53ba82784805479fa7341e3c9c3ca665
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Predicting the Outcome of Infectious Diseases: Variability among Inbred Mice as a New and Powerful Tool for Biomarker Discovery

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