Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders

The colony-stimulating factor 1 receptor (CSF1R) is a key tyrosine kinase transmembrane receptor modulating microglial homeostasis, neurogenesis, and neuronal survival in the central nervous system (CNS). CSF1R, which can be proteolytically cleaved into a soluble ectodomain and an intracellular prot...

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Autores principales:	Banglian Hu, Shengshun Duan, Ziwei Wang, Xin Li, Yuhang Zhou, Xian Zhang, Yun-Wu Zhang, Huaxi Xu, Honghua Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	CSF1R microglia microglial maintenance neurogenesis CSF1R cleavage CSF1R mutations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/53bb5fb9cc324956904e32d33c9434ab
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spelling	oai:doaj.org-article:53bb5fb9cc324956904e32d33c9434ab2021-11-15T07:00:19ZInsights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders1663-436510.3389/fnagi.2021.789834https://doaj.org/article/53bb5fb9cc324956904e32d33c9434ab2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.789834/fullhttps://doaj.org/toc/1663-4365The colony-stimulating factor 1 receptor (CSF1R) is a key tyrosine kinase transmembrane receptor modulating microglial homeostasis, neurogenesis, and neuronal survival in the central nervous system (CNS). CSF1R, which can be proteolytically cleaved into a soluble ectodomain and an intracellular protein fragment, supports the survival of myeloid cells upon activation by two ligands, colony stimulating factor 1 and interleukin 34. CSF1R loss-of-function mutations are the major cause of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and its dysfunction has also been implicated in other neurodegenerative disorders including Alzheimer’s disease (AD). Here, we review the physiological functions of CSF1R in the CNS and its pathological effects in neurological disorders including ALSP, AD, frontotemporal dementia and multiple sclerosis. Understanding the pathophysiology of CSF1R is critical for developing targeted therapies for related neurological diseases.Banglian HuShengshun DuanZiwei WangXin LiYuhang ZhouXian ZhangYun-Wu ZhangHuaxi XuHonghua ZhengHonghua ZhengFrontiers Media S.A.articleCSF1Rmicrogliamicroglial maintenanceneurogenesisCSF1R cleavageCSF1R mutationsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CSF1R microglia microglial maintenance neurogenesis CSF1R cleavage CSF1R mutations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	CSF1R microglia microglial maintenance neurogenesis CSF1R cleavage CSF1R mutations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Banglian Hu Shengshun Duan Ziwei Wang Xin Li Yuhang Zhou Xian Zhang Yun-Wu Zhang Huaxi Xu Honghua Zheng Honghua Zheng Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders
description	The colony-stimulating factor 1 receptor (CSF1R) is a key tyrosine kinase transmembrane receptor modulating microglial homeostasis, neurogenesis, and neuronal survival in the central nervous system (CNS). CSF1R, which can be proteolytically cleaved into a soluble ectodomain and an intracellular protein fragment, supports the survival of myeloid cells upon activation by two ligands, colony stimulating factor 1 and interleukin 34. CSF1R loss-of-function mutations are the major cause of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and its dysfunction has also been implicated in other neurodegenerative disorders including Alzheimer’s disease (AD). Here, we review the physiological functions of CSF1R in the CNS and its pathological effects in neurological disorders including ALSP, AD, frontotemporal dementia and multiple sclerosis. Understanding the pathophysiology of CSF1R is critical for developing targeted therapies for related neurological diseases.
format	article
author	Banglian Hu Shengshun Duan Ziwei Wang Xin Li Yuhang Zhou Xian Zhang Yun-Wu Zhang Huaxi Xu Honghua Zheng Honghua Zheng
author_facet	Banglian Hu Shengshun Duan Ziwei Wang Xin Li Yuhang Zhou Xian Zhang Yun-Wu Zhang Huaxi Xu Honghua Zheng Honghua Zheng
author_sort	Banglian Hu
title	Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders
title_short	Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders
title_full	Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders
title_fullStr	Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders
title_full_unstemmed	Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders
title_sort	insights into the role of csf1r in the central nervous system and neurological disorders
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/53bb5fb9cc324956904e32d33c9434ab
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Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders

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