Sialylation and muscle performance: sialic acid is a marker of muscle ageing.

Sialic acids (Sia) are widely expressed as terminal monosaccharides on eukaryotic glycoconjugates. They are involved in many cellular functions, such as cell-cell interaction and signal recognition. The key enzyme of sialic acid biosynthesis is the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-...

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Autores principales:	Frank Hanisch, Wenke Weidemann, Mona Großmann, Pushpa Raj Joshi, Hans-Jürgen Holzhausen, Gisela Stoltenburg, Joachim Weis, Stephan Zierz, Rüdiger Horstkorte
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/53bd6e0d6e864e77a2ddbf7051eced7b
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spelling	oai:doaj.org-article:53bd6e0d6e864e77a2ddbf7051eced7b2021-11-18T08:42:33ZSialylation and muscle performance: sialic acid is a marker of muscle ageing.1932-620310.1371/journal.pone.0080520https://doaj.org/article/53bd6e0d6e864e77a2ddbf7051eced7b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24349002/?tool=EBIhttps://doaj.org/toc/1932-6203Sialic acids (Sia) are widely expressed as terminal monosaccharides on eukaryotic glycoconjugates. They are involved in many cellular functions, such as cell-cell interaction and signal recognition. The key enzyme of sialic acid biosynthesis is the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), which catalyses the first two steps of Sia biosynthesis in the cytosol. In this study we analysed sialylation of muscles in wild type (C57Bl/6 GNE (+/+)) and heterozygous GNE-deficient (C57Bl/6 GNE (+/-)) mice. We measured a significantly lower performance in the initial weeks of a treadmill exercise in C57Bl/6 GNE (+/-) mice compared to wild type C57Bl/6 GNE (+/+) animals. Membrane bound Sia of C57Bl/6 GNE (+/-) mice were reduced by 33-53% at week 24 and by 12-15% at week 80 in comparison to C57Bl/6 GNE (+/+) mice. Interestingly, membrane bound Sia concentration increased with age of the mice by 16-46% in C57Bl/6 GNE (+/+), but by 87-207% in C57Bl/6 GNE (+/-). Furthermore we could identify specific morphological changes in aged muscles. Here we propose that increased Sia concentrations in muscles are a characteristic feature of ageing and could be used as a marker for age-related changes in muscle.Frank HanischWenke WeidemannMona GroßmannPushpa Raj JoshiHans-Jürgen HolzhausenGisela StoltenburgJoachim WeisStephan ZierzRüdiger HorstkortePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e80520 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Frank Hanisch Wenke Weidemann Mona Großmann Pushpa Raj Joshi Hans-Jürgen Holzhausen Gisela Stoltenburg Joachim Weis Stephan Zierz Rüdiger Horstkorte Sialylation and muscle performance: sialic acid is a marker of muscle ageing.
description	Sialic acids (Sia) are widely expressed as terminal monosaccharides on eukaryotic glycoconjugates. They are involved in many cellular functions, such as cell-cell interaction and signal recognition. The key enzyme of sialic acid biosynthesis is the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), which catalyses the first two steps of Sia biosynthesis in the cytosol. In this study we analysed sialylation of muscles in wild type (C57Bl/6 GNE (+/+)) and heterozygous GNE-deficient (C57Bl/6 GNE (+/-)) mice. We measured a significantly lower performance in the initial weeks of a treadmill exercise in C57Bl/6 GNE (+/-) mice compared to wild type C57Bl/6 GNE (+/+) animals. Membrane bound Sia of C57Bl/6 GNE (+/-) mice were reduced by 33-53% at week 24 and by 12-15% at week 80 in comparison to C57Bl/6 GNE (+/+) mice. Interestingly, membrane bound Sia concentration increased with age of the mice by 16-46% in C57Bl/6 GNE (+/+), but by 87-207% in C57Bl/6 GNE (+/-). Furthermore we could identify specific morphological changes in aged muscles. Here we propose that increased Sia concentrations in muscles are a characteristic feature of ageing and could be used as a marker for age-related changes in muscle.
format	article
author	Frank Hanisch Wenke Weidemann Mona Großmann Pushpa Raj Joshi Hans-Jürgen Holzhausen Gisela Stoltenburg Joachim Weis Stephan Zierz Rüdiger Horstkorte
author_facet	Frank Hanisch Wenke Weidemann Mona Großmann Pushpa Raj Joshi Hans-Jürgen Holzhausen Gisela Stoltenburg Joachim Weis Stephan Zierz Rüdiger Horstkorte
author_sort	Frank Hanisch
title	Sialylation and muscle performance: sialic acid is a marker of muscle ageing.
title_short	Sialylation and muscle performance: sialic acid is a marker of muscle ageing.
title_full	Sialylation and muscle performance: sialic acid is a marker of muscle ageing.
title_fullStr	Sialylation and muscle performance: sialic acid is a marker of muscle ageing.
title_full_unstemmed	Sialylation and muscle performance: sialic acid is a marker of muscle ageing.
title_sort	sialylation and muscle performance: sialic acid is a marker of muscle ageing.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/53bd6e0d6e864e77a2ddbf7051eced7b
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Sialylation and muscle performance: sialic acid is a marker of muscle ageing.

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