Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P

Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P

Abstract Selenoprotein biosynthesis relies on the co-translational insertion of selenocysteine in response to UGA codons. Aminoglycoside antibiotics interfere with ribosomal function and may cause codon misreading. We hypothesized that biosynthesis of the selenium (Se) transporter selenoprotein P (S...

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Autores principales: Kostja Renko, Janine Martitz, Sandra Hybsier, Bjoern Heynisch, Linn Voss, Robert A. Everley, Steven P. Gygi, Mette Stoedter, Monika Wisniewska, Josef Köhrle, Vadim N. Gladyshev, Lutz Schomburg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/53c13c6cf1a34777988a908974caa136
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