Role of new Immunophenotypic Markers on Prognostic and Overall Survival of Acute Myeloid Leukemia: a Systematic Review and Meta-Analysis

Abstract Despite technological advances, the prognosis and survival of acute myeloid leukemia (AML) adult patients remain low, compared with other hematologic malignancies. Some antigens detected by immunophenotyping may soon play a significant role in the pathophysiologic, prognostic, and overall s...

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Autores principales:	A. F. O. Costa, D. L. Menezes, L. H. S. Pinheiro, A. F. Sandes, M. A. P. Nunes, D. P. Lyra Junior, D. M. Schimieguel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/53c42a5290b14003b8c1a303b3610c47
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spelling	oai:doaj.org-article:53c42a5290b14003b8c1a303b3610c472021-12-02T15:06:02ZRole of new Immunophenotypic Markers on Prognostic and Overall Survival of Acute Myeloid Leukemia: a Systematic Review and Meta-Analysis10.1038/s41598-017-00816-22045-2322https://doaj.org/article/53c42a5290b14003b8c1a303b3610c472017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00816-2https://doaj.org/toc/2045-2322Abstract Despite technological advances, the prognosis and survival of acute myeloid leukemia (AML) adult patients remain low, compared with other hematologic malignancies. Some antigens detected by immunophenotyping may soon play a significant role in the pathophysiologic, prognostic, and overall survival (OS) rate of AML patients. Therefore, we conducted a systematic review and meta-analysis of PubMed, Scopus, Science Direct, Web of Science, and the Cochrane Library (using PRISMA guidelines). We analyzed 11 studies and 13 antigens, detected through the immunophenotyping of 639 patients. From them, twelve exhibited a negative impact with AML prognosis. The meta-analysis demonstrated a high expression of AML markers, which have been associated with a decrease in survival over 10 months (RR 2.55; IC 95%; 1.49–4.37) and over 20 months (RR 2.46; IC 95%; 1.75–3.45). Knowing that the expression of immunophenotypic markers, which are not used on a routine basis, might be able to influence disease behavior, looks promising. However, they have been associated with a poor prognosis as well as a decrease in survival. This may allow for different chemotherapeutical protocols, including future studies for new therapeutic targets.A. F. O. CostaD. L. MenezesL. H. S. PinheiroA. F. SandesM. A. P. NunesD. P. Lyra JuniorD. M. SchimieguelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. F. O. Costa D. L. Menezes L. H. S. Pinheiro A. F. Sandes M. A. P. Nunes D. P. Lyra Junior D. M. Schimieguel Role of new Immunophenotypic Markers on Prognostic and Overall Survival of Acute Myeloid Leukemia: a Systematic Review and Meta-Analysis
description	Abstract Despite technological advances, the prognosis and survival of acute myeloid leukemia (AML) adult patients remain low, compared with other hematologic malignancies. Some antigens detected by immunophenotyping may soon play a significant role in the pathophysiologic, prognostic, and overall survival (OS) rate of AML patients. Therefore, we conducted a systematic review and meta-analysis of PubMed, Scopus, Science Direct, Web of Science, and the Cochrane Library (using PRISMA guidelines). We analyzed 11 studies and 13 antigens, detected through the immunophenotyping of 639 patients. From them, twelve exhibited a negative impact with AML prognosis. The meta-analysis demonstrated a high expression of AML markers, which have been associated with a decrease in survival over 10 months (RR 2.55; IC 95%; 1.49–4.37) and over 20 months (RR 2.46; IC 95%; 1.75–3.45). Knowing that the expression of immunophenotypic markers, which are not used on a routine basis, might be able to influence disease behavior, looks promising. However, they have been associated with a poor prognosis as well as a decrease in survival. This may allow for different chemotherapeutical protocols, including future studies for new therapeutic targets.
format	article
author	A. F. O. Costa D. L. Menezes L. H. S. Pinheiro A. F. Sandes M. A. P. Nunes D. P. Lyra Junior D. M. Schimieguel
author_facet	A. F. O. Costa D. L. Menezes L. H. S. Pinheiro A. F. Sandes M. A. P. Nunes D. P. Lyra Junior D. M. Schimieguel
author_sort	A. F. O. Costa
title	Role of new Immunophenotypic Markers on Prognostic and Overall Survival of Acute Myeloid Leukemia: a Systematic Review and Meta-Analysis
title_short	Role of new Immunophenotypic Markers on Prognostic and Overall Survival of Acute Myeloid Leukemia: a Systematic Review and Meta-Analysis
title_full	Role of new Immunophenotypic Markers on Prognostic and Overall Survival of Acute Myeloid Leukemia: a Systematic Review and Meta-Analysis
title_fullStr	Role of new Immunophenotypic Markers on Prognostic and Overall Survival of Acute Myeloid Leukemia: a Systematic Review and Meta-Analysis
title_full_unstemmed	Role of new Immunophenotypic Markers on Prognostic and Overall Survival of Acute Myeloid Leukemia: a Systematic Review and Meta-Analysis
title_sort	role of new immunophenotypic markers on prognostic and overall survival of acute myeloid leukemia: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/53c42a5290b14003b8c1a303b3610c47
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Role of new Immunophenotypic Markers on Prognostic and Overall Survival of Acute Myeloid Leukemia: a Systematic Review and Meta-Analysis

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