Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands

Barrett’s oesophagus is associated with an increased risk of oseophageal cancer, but its cell of origin is unclear. Here the authors show, using single-cell RNA sequencing of biopsies from six patients and two unaffected subjects, that cells in Barrett’s oesophagus show a transcriptional profile tha...

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Autores principales:	Richard Peter Owen, Michael Joseph White, David Tyler Severson, Barbara Braden, Adam Bailey, Robert Goldin, Lai Mun Wang, Carlos Ruiz-Puig, Nicholas David Maynard, Angie Green, Paolo Piazza, David Buck, Mark Ross Middleton, Chris Paul Ponting, Benjamin Schuster-Böckler, Xin Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53c87fc54c1542f789eced6b76559b59
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spelling	oai:doaj.org-article:53c87fc54c1542f789eced6b76559b592021-12-02T15:34:42ZSingle cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands10.1038/s41467-018-06796-92041-1723https://doaj.org/article/53c87fc54c1542f789eced6b76559b592018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06796-9https://doaj.org/toc/2041-1723Barrett’s oesophagus is associated with an increased risk of oseophageal cancer, but its cell of origin is unclear. Here the authors show, using single-cell RNA sequencing of biopsies from six patients and two unaffected subjects, that cells in Barrett’s oesophagus show a transcriptional profile that is similar to that of cells in oesophageal submucosal glands.Richard Peter OwenMichael Joseph WhiteDavid Tyler SeversonBarbara BradenAdam BaileyRobert GoldinLai Mun WangCarlos Ruiz-PuigNicholas David MaynardAngie GreenPaolo PiazzaDavid BuckMark Ross MiddletonChris Paul PontingBenjamin Schuster-BöcklerXin LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Richard Peter Owen Michael Joseph White David Tyler Severson Barbara Braden Adam Bailey Robert Goldin Lai Mun Wang Carlos Ruiz-Puig Nicholas David Maynard Angie Green Paolo Piazza David Buck Mark Ross Middleton Chris Paul Ponting Benjamin Schuster-Böckler Xin Lu Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands
description	Barrett’s oesophagus is associated with an increased risk of oseophageal cancer, but its cell of origin is unclear. Here the authors show, using single-cell RNA sequencing of biopsies from six patients and two unaffected subjects, that cells in Barrett’s oesophagus show a transcriptional profile that is similar to that of cells in oesophageal submucosal glands.
format	article
author	Richard Peter Owen Michael Joseph White David Tyler Severson Barbara Braden Adam Bailey Robert Goldin Lai Mun Wang Carlos Ruiz-Puig Nicholas David Maynard Angie Green Paolo Piazza David Buck Mark Ross Middleton Chris Paul Ponting Benjamin Schuster-Böckler Xin Lu
author_facet	Richard Peter Owen Michael Joseph White David Tyler Severson Barbara Braden Adam Bailey Robert Goldin Lai Mun Wang Carlos Ruiz-Puig Nicholas David Maynard Angie Green Paolo Piazza David Buck Mark Ross Middleton Chris Paul Ponting Benjamin Schuster-Böckler Xin Lu
author_sort	Richard Peter Owen
title	Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands
title_short	Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands
title_full	Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands
title_fullStr	Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands
title_full_unstemmed	Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands
title_sort	single cell rna-seq reveals profound transcriptional similarity between barrett’s oesophagus and oesophageal submucosal glands
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/53c87fc54c1542f789eced6b76559b59
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Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands

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