Radiofrequency Ablation a Safe and Effective Treatment for Pediatric Benign Nodular Thyroid Goiter

Purpose: To evaluate the effectiveness of radiofrequency ablation (RFA) for benign thyroid nodules in pediatric patients.Materials and Methods: Twelve pediatric patients (11 female, 1 male; mean age 15.54 ± 2.8 years, range 10–19 years) with benign thyroid nodules (mean longest diameter 4.1 ± 1.4 cm...

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Autores principales:	An-Ni Lin, Wei-Che Lin, Kai-Lun Cheng, Sheng-Dean Luo, Pi-Ling Chiang, Wei-Chih Chen, Yueh-Sheng Chen, Cheng-Kang Wang, Na-Ning Kan, Yan-Ye Su
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	radiofrequency ablation thyroid gland children pediatric goiter ultrasound Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/53ca273a7096479fa93c5bb99d4d7149
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spelling	oai:doaj.org-article:53ca273a7096479fa93c5bb99d4d71492021-12-01T07:54:44ZRadiofrequency Ablation a Safe and Effective Treatment for Pediatric Benign Nodular Thyroid Goiter2296-236010.3389/fped.2021.753343https://doaj.org/article/53ca273a7096479fa93c5bb99d4d71492021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.753343/fullhttps://doaj.org/toc/2296-2360Purpose: To evaluate the effectiveness of radiofrequency ablation (RFA) for benign thyroid nodules in pediatric patients.Materials and Methods: Twelve pediatric patients (11 female, 1 male; mean age 15.54 ± 2.8 years, range 10–19 years) with benign thyroid nodules (mean longest diameter 4.1 ± 1.4 cm, range 1.5–5.9 cm) treated by RFA from 2017 to 2020 were evaluated. The inclusion criteria for RFA therapy were (i) age < 20 years; (ii) benign cytological confirmation by 2 separate ultrasound guided fine-needle aspiration cytology (FNAC) or core needle biopsies; (iii) pressure symptoms or cosmetic problems caused by thyroid nodules; (iv) absence of any sonographic suspicious feature; and (v) follow-up for >6 months. Under local anesthesia, RFA was performed with the use of an RF generator and an 18-gauge internally cooled electrode. Volume changes in nodules on follow-up ultrasonography (US), changes in symptomatic and cosmetic scores, and complications arising during or after RFA were evaluated.Results: Mean follow-up period was 24.9 ± 13.9 months (range 6–43 months). At the last follow-up visits, volume of the nodule had decreased significantly (15.34 ± 11.52 mL vs. 4.07 ± 4.99 mL; P < 0.05), whereas volume reduction rate was 74.31% ± 19.59%. Both cosmetic and compressive symptoms were also significantly improved (2.91 ± 0.79 vs. 0.92 ± 0.67 and 1.5 ± 1.93 vs. 0.17 ± 0.39; P < 0.05). The mean number of ablation sessions was 1.4 ± 0.6 (range 1–3 sessions), and one of the patients suffered from transient vocal cord palsy which was spontaneously resolved 53 days later.Conclusions: RFA is a safe and effective treatment for benign thyroid nodules in pediatric patients, and can thus serve as an alternative treatment for thyroidectomy.An-Ni LinWei-Che LinKai-Lun ChengKai-Lun ChengSheng-Dean LuoPi-Ling ChiangWei-Chih ChenYueh-Sheng ChenCheng-Kang WangNa-Ning KanYan-Ye SuFrontiers Media S.A.articleradiofrequency ablationthyroid glandchildrenpediatricgoiterultrasoundPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiofrequency ablation thyroid gland children pediatric goiter ultrasound Pediatrics RJ1-570
spellingShingle	radiofrequency ablation thyroid gland children pediatric goiter ultrasound Pediatrics RJ1-570 An-Ni Lin Wei-Che Lin Kai-Lun Cheng Kai-Lun Cheng Sheng-Dean Luo Pi-Ling Chiang Wei-Chih Chen Yueh-Sheng Chen Cheng-Kang Wang Na-Ning Kan Yan-Ye Su Radiofrequency Ablation a Safe and Effective Treatment for Pediatric Benign Nodular Thyroid Goiter
description	Purpose: To evaluate the effectiveness of radiofrequency ablation (RFA) for benign thyroid nodules in pediatric patients.Materials and Methods: Twelve pediatric patients (11 female, 1 male; mean age 15.54 ± 2.8 years, range 10–19 years) with benign thyroid nodules (mean longest diameter 4.1 ± 1.4 cm, range 1.5–5.9 cm) treated by RFA from 2017 to 2020 were evaluated. The inclusion criteria for RFA therapy were (i) age < 20 years; (ii) benign cytological confirmation by 2 separate ultrasound guided fine-needle aspiration cytology (FNAC) or core needle biopsies; (iii) pressure symptoms or cosmetic problems caused by thyroid nodules; (iv) absence of any sonographic suspicious feature; and (v) follow-up for >6 months. Under local anesthesia, RFA was performed with the use of an RF generator and an 18-gauge internally cooled electrode. Volume changes in nodules on follow-up ultrasonography (US), changes in symptomatic and cosmetic scores, and complications arising during or after RFA were evaluated.Results: Mean follow-up period was 24.9 ± 13.9 months (range 6–43 months). At the last follow-up visits, volume of the nodule had decreased significantly (15.34 ± 11.52 mL vs. 4.07 ± 4.99 mL; P < 0.05), whereas volume reduction rate was 74.31% ± 19.59%. Both cosmetic and compressive symptoms were also significantly improved (2.91 ± 0.79 vs. 0.92 ± 0.67 and 1.5 ± 1.93 vs. 0.17 ± 0.39; P < 0.05). The mean number of ablation sessions was 1.4 ± 0.6 (range 1–3 sessions), and one of the patients suffered from transient vocal cord palsy which was spontaneously resolved 53 days later.Conclusions: RFA is a safe and effective treatment for benign thyroid nodules in pediatric patients, and can thus serve as an alternative treatment for thyroidectomy.
format	article
author	An-Ni Lin Wei-Che Lin Kai-Lun Cheng Kai-Lun Cheng Sheng-Dean Luo Pi-Ling Chiang Wei-Chih Chen Yueh-Sheng Chen Cheng-Kang Wang Na-Ning Kan Yan-Ye Su
author_facet	An-Ni Lin Wei-Che Lin Kai-Lun Cheng Kai-Lun Cheng Sheng-Dean Luo Pi-Ling Chiang Wei-Chih Chen Yueh-Sheng Chen Cheng-Kang Wang Na-Ning Kan Yan-Ye Su
author_sort	An-Ni Lin
title	Radiofrequency Ablation a Safe and Effective Treatment for Pediatric Benign Nodular Thyroid Goiter
title_short	Radiofrequency Ablation a Safe and Effective Treatment for Pediatric Benign Nodular Thyroid Goiter
title_full	Radiofrequency Ablation a Safe and Effective Treatment for Pediatric Benign Nodular Thyroid Goiter
title_fullStr	Radiofrequency Ablation a Safe and Effective Treatment for Pediatric Benign Nodular Thyroid Goiter
title_full_unstemmed	Radiofrequency Ablation a Safe and Effective Treatment for Pediatric Benign Nodular Thyroid Goiter
title_sort	radiofrequency ablation a safe and effective treatment for pediatric benign nodular thyroid goiter
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/53ca273a7096479fa93c5bb99d4d7149
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Radiofrequency Ablation a Safe and Effective Treatment for Pediatric Benign Nodular Thyroid Goiter

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