Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases

The transmembrane protein 16 (TMEM16) family consists of Ca2+-activated ion channels and Ca2+-activated phospholipid scramblases (CaPLSases) that passively flip-flop phospholipids between the two leaflets of the membrane bilayer. Owing to their diverse functions, TMEM16 proteins have been implicated...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Son C. Le, Pengfei Liang, Augustus J. Lowry, Huanghe Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	TMEM16 Anoctamin CaCC lipid scramblase phosphatidylserine PIP2 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/53cba41171754598a160f74ffca01b60
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:53cba41171754598a160f74ffca01b60
record_format	dspace
spelling	oai:doaj.org-article:53cba41171754598a160f74ffca01b602021-11-19T07:41:54ZGating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases1664-042X10.3389/fphys.2021.787773https://doaj.org/article/53cba41171754598a160f74ffca01b602021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.787773/fullhttps://doaj.org/toc/1664-042XThe transmembrane protein 16 (TMEM16) family consists of Ca2+-activated ion channels and Ca2+-activated phospholipid scramblases (CaPLSases) that passively flip-flop phospholipids between the two leaflets of the membrane bilayer. Owing to their diverse functions, TMEM16 proteins have been implicated in various human diseases, including asthma, cancer, bleeding disorders, muscular dystrophy, arthritis, epilepsy, dystonia, ataxia, and viral infection. To understand TMEM16 proteins in health and disease, it is critical to decipher their molecular mechanisms of activation gating and regulation. Structural, biophysical, and computational characterizations over the past decade have greatly advanced the molecular understanding of TMEM16 proteins. In this review, we summarize major structural features of the TMEM16 proteins with a focus on regulatory mechanisms and gating.Son C. LePengfei LiangAugustus J. LowryHuanghe YangHuanghe YangFrontiers Media S.A.articleTMEM16AnoctaminCaCClipid scramblasephosphatidylserinePIP2PhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TMEM16 Anoctamin CaCC lipid scramblase phosphatidylserine PIP2 Physiology QP1-981
spellingShingle	TMEM16 Anoctamin CaCC lipid scramblase phosphatidylserine PIP2 Physiology QP1-981 Son C. Le Pengfei Liang Augustus J. Lowry Huanghe Yang Huanghe Yang Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases
description	The transmembrane protein 16 (TMEM16) family consists of Ca2+-activated ion channels and Ca2+-activated phospholipid scramblases (CaPLSases) that passively flip-flop phospholipids between the two leaflets of the membrane bilayer. Owing to their diverse functions, TMEM16 proteins have been implicated in various human diseases, including asthma, cancer, bleeding disorders, muscular dystrophy, arthritis, epilepsy, dystonia, ataxia, and viral infection. To understand TMEM16 proteins in health and disease, it is critical to decipher their molecular mechanisms of activation gating and regulation. Structural, biophysical, and computational characterizations over the past decade have greatly advanced the molecular understanding of TMEM16 proteins. In this review, we summarize major structural features of the TMEM16 proteins with a focus on regulatory mechanisms and gating.
format	article
author	Son C. Le Pengfei Liang Augustus J. Lowry Huanghe Yang Huanghe Yang
author_facet	Son C. Le Pengfei Liang Augustus J. Lowry Huanghe Yang Huanghe Yang
author_sort	Son C. Le
title	Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases
title_short	Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases
title_full	Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases
title_fullStr	Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases
title_full_unstemmed	Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases
title_sort	gating and regulatory mechanisms of tmem16 ion channels and scramblases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/53cba41171754598a160f74ffca01b60
work_keys_str_mv	AT soncle gatingandregulatorymechanismsoftmem16ionchannelsandscramblases AT pengfeiliang gatingandregulatorymechanismsoftmem16ionchannelsandscramblases AT augustusjlowry gatingandregulatorymechanismsoftmem16ionchannelsandscramblases AT huangheyang gatingandregulatorymechanismsoftmem16ionchannelsandscramblases AT huangheyang gatingandregulatorymechanismsoftmem16ionchannelsandscramblases
_version_	1718420259071852544

Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases

Ejemplares similares