Tetraploidy causes chromosomal instability in acentriolar mouse embryos

During cell division, tetraploidy can drive chromosomal instability (CIN) via supernumerary centrosomes, but it is unclear if this is the only route to CIN. Here the authors show that, in early mouse embryos, tetraploidy can drive chromosomal instability by altering microtubule dynamics and attachme...

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Autores principales:	Lia Mara Gomes Paim, Greg FitzHarris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53cbfb88ce1242519e1fc5030b2557b8
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spelling	oai:doaj.org-article:53cbfb88ce1242519e1fc5030b2557b82021-12-02T16:57:21ZTetraploidy causes chromosomal instability in acentriolar mouse embryos10.1038/s41467-019-12772-82041-1723https://doaj.org/article/53cbfb88ce1242519e1fc5030b2557b82019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12772-8https://doaj.org/toc/2041-1723During cell division, tetraploidy can drive chromosomal instability (CIN) via supernumerary centrosomes, but it is unclear if this is the only route to CIN. Here the authors show that, in early mouse embryos, tetraploidy can drive chromosomal instability by altering microtubule dynamics and attachment.Lia Mara Gomes PaimGreg FitzHarrisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lia Mara Gomes Paim Greg FitzHarris Tetraploidy causes chromosomal instability in acentriolar mouse embryos
description	During cell division, tetraploidy can drive chromosomal instability (CIN) via supernumerary centrosomes, but it is unclear if this is the only route to CIN. Here the authors show that, in early mouse embryos, tetraploidy can drive chromosomal instability by altering microtubule dynamics and attachment.
format	article
author	Lia Mara Gomes Paim Greg FitzHarris
author_facet	Lia Mara Gomes Paim Greg FitzHarris
author_sort	Lia Mara Gomes Paim
title	Tetraploidy causes chromosomal instability in acentriolar mouse embryos
title_short	Tetraploidy causes chromosomal instability in acentriolar mouse embryos
title_full	Tetraploidy causes chromosomal instability in acentriolar mouse embryos
title_fullStr	Tetraploidy causes chromosomal instability in acentriolar mouse embryos
title_full_unstemmed	Tetraploidy causes chromosomal instability in acentriolar mouse embryos
title_sort	tetraploidy causes chromosomal instability in acentriolar mouse embryos
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/53cbfb88ce1242519e1fc5030b2557b8
work_keys_str_mv	AT liamaragomespaim tetraploidycauseschromosomalinstabilityinacentriolarmouseembryos AT gregfitzharris tetraploidycauseschromosomalinstabilityinacentriolarmouseembryos
_version_	1718382563778625536

Tetraploidy causes chromosomal instability in acentriolar mouse embryos

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