Tetraploidy causes chromosomal instability in acentriolar mouse embryos

During cell division, tetraploidy can drive chromosomal instability (CIN) via supernumerary centrosomes, but it is unclear if this is the only route to CIN. Here the authors show that, in early mouse embryos, tetraploidy can drive chromosomal instability by altering microtubule dynamics and attachme...

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Autores principales: Lia Mara Gomes Paim, Greg FitzHarris
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/53cbfb88ce1242519e1fc5030b2557b8
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