Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study

In this paper, the interaction of imipramine hydrochloride (IMP, antidepressant drug) and a non-ionic surfactant Triton X-100 (TX-100) mixture in five different ratios through the tensiometric method in different solvents (aqueous/0.050 mol·kg<sup>−1</sup> aqueous NaCl/0.250 mol·kg<su...

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Autores principales:	Malik Abdul Rub, Naved Azum, Dileep Kumar, Muhammad Nadeem Arshad, Anish Khan, Maha Moteb Alotaibi, Abdullah M. Asiri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	imipramine hydrochloride tensiometry mixed micelles interaction parameter micellar composition Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/53cd119dbcad4ae8af24fb5a8763e68f
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spelling	oai:doaj.org-article:53cd119dbcad4ae8af24fb5a8763e68f2021-11-25T18:49:29ZInvestigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study10.3390/polym132240252073-4360https://doaj.org/article/53cd119dbcad4ae8af24fb5a8763e68f2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/4025https://doaj.org/toc/2073-4360In this paper, the interaction of imipramine hydrochloride (IMP, antidepressant drug) and a non-ionic surfactant Triton X-100 (TX-100) mixture in five different ratios through the tensiometric method in different solvents (aqueous/0.050 mol·kg<sup>−1</sup> aqueous NaCl/0.250 mol·kg<sup>−1</sup> aqueous urea (U)) were examined thoroughly at a temperature of 298 K. UV–Visible studies in an aqueous system of IMP + TX-100 mixtures were also investigated and discussed in detail. The pure (IMP and TX-100) along with the mixtures’ critical micelle concentration (<i>cmc</i>) were assessed by a tensiometric technique. The obtained deviation of the mixtures’ <i>cmc</i> values from their ideal values revealed the nonideal behavior of IMP + TX-100 mixtures amongst IMP and TX-100. Compared to aqueous systems, in the presence of aqueous NaCl, several changes in micelles/mixed micelles occurred, and hence a synergism/attractive interaction amongst components was found increased while in the existence of U, the synergism/attractive interaction between them decreased. The evaluated interaction parameter (<i>β</i><sup>Rb</sup>) value of mixed micelles showed the attractive or synergism between the IMP and TX-100. Various evaluated thermodynamic parameters in an aqueous system showed that the mixed micellization of the IMP + TX-100 mixture was an entropically spontaneous phenomenon, although the existence of salt in all studied systems can somewhat increase the spontaneity of the micellization process and in the aqueous U system, the spontaneity of the micellization process decreased. In an aqueous system, the interaction between IMP and TX-100 was also confirmed by UV–Visible study.Malik Abdul RubNaved AzumDileep KumarMuhammad Nadeem ArshadAnish KhanMaha Moteb AlotaibiAbdullah M. AsiriMDPI AGarticleimipramine hydrochloridetensiometrymixed micellesinteraction parametermicellar compositionOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 4025, p 4025 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	imipramine hydrochloride tensiometry mixed micelles interaction parameter micellar composition Organic chemistry QD241-441
spellingShingle	imipramine hydrochloride tensiometry mixed micelles interaction parameter micellar composition Organic chemistry QD241-441 Malik Abdul Rub Naved Azum Dileep Kumar Muhammad Nadeem Arshad Anish Khan Maha Moteb Alotaibi Abdullah M. Asiri Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study
description	In this paper, the interaction of imipramine hydrochloride (IMP, antidepressant drug) and a non-ionic surfactant Triton X-100 (TX-100) mixture in five different ratios through the tensiometric method in different solvents (aqueous/0.050 mol·kg<sup>−1</sup> aqueous NaCl/0.250 mol·kg<sup>−1</sup> aqueous urea (U)) were examined thoroughly at a temperature of 298 K. UV–Visible studies in an aqueous system of IMP + TX-100 mixtures were also investigated and discussed in detail. The pure (IMP and TX-100) along with the mixtures’ critical micelle concentration (<i>cmc</i>) were assessed by a tensiometric technique. The obtained deviation of the mixtures’ <i>cmc</i> values from their ideal values revealed the nonideal behavior of IMP + TX-100 mixtures amongst IMP and TX-100. Compared to aqueous systems, in the presence of aqueous NaCl, several changes in micelles/mixed micelles occurred, and hence a synergism/attractive interaction amongst components was found increased while in the existence of U, the synergism/attractive interaction between them decreased. The evaluated interaction parameter (<i>β</i><sup>Rb</sup>) value of mixed micelles showed the attractive or synergism between the IMP and TX-100. Various evaluated thermodynamic parameters in an aqueous system showed that the mixed micellization of the IMP + TX-100 mixture was an entropically spontaneous phenomenon, although the existence of salt in all studied systems can somewhat increase the spontaneity of the micellization process and in the aqueous U system, the spontaneity of the micellization process decreased. In an aqueous system, the interaction between IMP and TX-100 was also confirmed by UV–Visible study.
format	article
author	Malik Abdul Rub Naved Azum Dileep Kumar Muhammad Nadeem Arshad Anish Khan Maha Moteb Alotaibi Abdullah M. Asiri
author_facet	Malik Abdul Rub Naved Azum Dileep Kumar Muhammad Nadeem Arshad Anish Khan Maha Moteb Alotaibi Abdullah M. Asiri
author_sort	Malik Abdul Rub
title	Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study
title_short	Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study
title_full	Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study
title_fullStr	Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study
title_full_unstemmed	Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study
title_sort	investigation of solution behavior of antidepressant imipramine hydrochloride drug and non-ionic surfactant mixture: experimental and theoretical study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/53cd119dbcad4ae8af24fb5a8763e68f
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Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study

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