Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion

Chronic antiretroviral therapy does not eradicate HIV infection. Here, the authors describe a potentially one-shot alternative by engineering B cells to express anti-HIV antibodies and undergo memory retention, isotype switching and clonal expansion

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Autores principales:	Alessio D. Nahmad, Yuval Raviv, Miriam Horovitz-Fried, Ilan Sofer, Tal Akriv, Daniel Nataf, Iris Dotan, Yaron Carmi, David Burstein, Yariv Wine, Itai Benhar, Adi Barzel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53cea78635c1437b9150abc735992dd8
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spelling	oai:doaj.org-article:53cea78635c1437b9150abc735992dd82021-12-02T17:32:43ZEngineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion10.1038/s41467-020-19649-12041-1723https://doaj.org/article/53cea78635c1437b9150abc735992dd82020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19649-1https://doaj.org/toc/2041-1723Chronic antiretroviral therapy does not eradicate HIV infection. Here, the authors describe a potentially one-shot alternative by engineering B cells to express anti-HIV antibodies and undergo memory retention, isotype switching and clonal expansionAlessio D. NahmadYuval RavivMiriam Horovitz-FriedIlan SoferTal AkrivDaniel NatafIris DotanYaron CarmiDavid BursteinYariv WineItai BenharAdi BarzelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessio D. Nahmad Yuval Raviv Miriam Horovitz-Fried Ilan Sofer Tal Akriv Daniel Nataf Iris Dotan Yaron Carmi David Burstein Yariv Wine Itai Benhar Adi Barzel Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
description	Chronic antiretroviral therapy does not eradicate HIV infection. Here, the authors describe a potentially one-shot alternative by engineering B cells to express anti-HIV antibodies and undergo memory retention, isotype switching and clonal expansion
format	article
author	Alessio D. Nahmad Yuval Raviv Miriam Horovitz-Fried Ilan Sofer Tal Akriv Daniel Nataf Iris Dotan Yaron Carmi David Burstein Yariv Wine Itai Benhar Adi Barzel
author_facet	Alessio D. Nahmad Yuval Raviv Miriam Horovitz-Fried Ilan Sofer Tal Akriv Daniel Nataf Iris Dotan Yaron Carmi David Burstein Yariv Wine Itai Benhar Adi Barzel
author_sort	Alessio D. Nahmad
title	Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
title_short	Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
title_full	Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
title_fullStr	Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
title_full_unstemmed	Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
title_sort	engineered b cells expressing an anti-hiv antibody enable memory retention, isotype switching and clonal expansion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/53cea78635c1437b9150abc735992dd8
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Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion

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