Characteristics of corneal stiffness parameters in keratoconus patients at different ages

AIM: To investigate the characteristics of corneal stiffness parameters at the first applanation(SP-A1)in keratoconus patients among different age groups and severity classification groups. METHODS: A cross-sectional study. Three hundred and forty-five eyes of 247 consecutive keratoconus patients di...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sheng-Wei Ren, Yu-Wei Gu, Li-Yan Xu, Qi Fan, Kai-Li Yang
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	keratoconus corneal hardness parameter age disease severity amsler-krumeich classification corneal biomechanics Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/53cee9d4ab9b4d4abddd1638740cac87
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:53cee9d4ab9b4d4abddd1638740cac87
record_format	dspace
spelling	oai:doaj.org-article:53cee9d4ab9b4d4abddd1638740cac872021-11-22T14:22:32ZCharacteristics of corneal stiffness parameters in keratoconus patients at different ages1672-512310.3980/j.issn.1672-5123.2021.12.07https://doaj.org/article/53cee9d4ab9b4d4abddd1638740cac872021-12-01T00:00:00Zhttp://ies.ijo.cn/cn_publish/2021/12/202112007.pdfhttps://doaj.org/toc/1672-5123AIM: To investigate the characteristics of corneal stiffness parameters at the first applanation(SP-A1)in keratoconus patients among different age groups and severity classification groups. METHODS: A cross-sectional study. Three hundred and forty-five eyes of 247 consecutive keratoconus patients diagnosed in Henan Eye Hospital were enrolled during September 2018 to December 2020. The mean age was(24.51±6.38)years. According to age, the subjects were divided into ≤20 years group, 21-30 years group and ≥31 years group. The severity of keratoconus was divided into AK1, AK2, AK3 and AK4 by Amsler krumeich(AK)classification method. The visual acuity, corneal flat curvature(K1), corneal steep curvature(K2), average corneal curvature(Km)and the thinnest corneal thickness(TCT)were measured. The SP-A1, intraocular pressure(IOP), deformation amplitude max(DA Max), velocity at the first applanation(A1V), time at the first applanation(A1T), time at the second applanation(A2T), velocity at the second applanation(A2V), biomechanical corrected IOP(bIOP), and Radius were measured by Corneal Visualization Scheimpflug Technology(Corvis ST). The correlation between SP-A1 and other parameters were analyzed by Spearman rank correlation, and one-way ANOVA was used to analyze the difference of SP-A1 among different age groups or disease severity groups. RESULTS: No statistically differences of gender, visual acuity, IOP, K1, K2, Km, TCT and disease severity classification were found among different age groups(P>0.05). The SP-A1 was positively related to age(rs=0.137, P=0.011). The SP-A1 of keratoconus patients in the ≥31 years group was significantly higher than that in the ≤20 years group and 21-30 years group(P<0.05). SP-A1 was negatively correlated with K1, K2 and Km in patients in the ≤20 years group and 21-30 years group, while SP-A1 was negatively correlated with K2 in patients in the ≥31 years group(P<0.05). In addition, SP-A1 was negatively correlated with DA Max, A1V and A2T, and positively correlated with TCT, IOP, bIOP, A1T, A2V and Radius. With the increase of disease severity, the SP-A1 values gradually decreased in patients in the ≤20 years group and 21-30 years group(P<0.05). The values of SP-A1 between AK1 and AK4, AK2 and AK3, AK2 and AK4 were statistically different(P=0.008, 0.035, 0.001). CONCLUSION: The value of SP-A1 in keratoconus was positively correlated with age. In patients less than 30 years old, the SP-A1 decreased with the increase of disease severity.Sheng-Wei RenYu-Wei GuLi-Yan XuQi FanKai-Li YangPress of International Journal of Ophthalmology (IJO PRESS)articlekeratoconuscorneal hardness parameteragedisease severityamsler-krumeich classificationcorneal biomechanicsOphthalmologyRE1-994ENGuoji Yanke Zazhi, Vol 21, Iss 12, Pp 2060-2065 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	keratoconus corneal hardness parameter age disease severity amsler-krumeich classification corneal biomechanics Ophthalmology RE1-994
spellingShingle	keratoconus corneal hardness parameter age disease severity amsler-krumeich classification corneal biomechanics Ophthalmology RE1-994 Sheng-Wei Ren Yu-Wei Gu Li-Yan Xu Qi Fan Kai-Li Yang Characteristics of corneal stiffness parameters in keratoconus patients at different ages
description	AIM: To investigate the characteristics of corneal stiffness parameters at the first applanation(SP-A1)in keratoconus patients among different age groups and severity classification groups. METHODS: A cross-sectional study. Three hundred and forty-five eyes of 247 consecutive keratoconus patients diagnosed in Henan Eye Hospital were enrolled during September 2018 to December 2020. The mean age was(24.51±6.38)years. According to age, the subjects were divided into ≤20 years group, 21-30 years group and ≥31 years group. The severity of keratoconus was divided into AK1, AK2, AK3 and AK4 by Amsler krumeich(AK)classification method. The visual acuity, corneal flat curvature(K1), corneal steep curvature(K2), average corneal curvature(Km)and the thinnest corneal thickness(TCT)were measured. The SP-A1, intraocular pressure(IOP), deformation amplitude max(DA Max), velocity at the first applanation(A1V), time at the first applanation(A1T), time at the second applanation(A2T), velocity at the second applanation(A2V), biomechanical corrected IOP(bIOP), and Radius were measured by Corneal Visualization Scheimpflug Technology(Corvis ST). The correlation between SP-A1 and other parameters were analyzed by Spearman rank correlation, and one-way ANOVA was used to analyze the difference of SP-A1 among different age groups or disease severity groups. RESULTS: No statistically differences of gender, visual acuity, IOP, K1, K2, Km, TCT and disease severity classification were found among different age groups(P>0.05). The SP-A1 was positively related to age(rs=0.137, P=0.011). The SP-A1 of keratoconus patients in the ≥31 years group was significantly higher than that in the ≤20 years group and 21-30 years group(P<0.05). SP-A1 was negatively correlated with K1, K2 and Km in patients in the ≤20 years group and 21-30 years group, while SP-A1 was negatively correlated with K2 in patients in the ≥31 years group(P<0.05). In addition, SP-A1 was negatively correlated with DA Max, A1V and A2T, and positively correlated with TCT, IOP, bIOP, A1T, A2V and Radius. With the increase of disease severity, the SP-A1 values gradually decreased in patients in the ≤20 years group and 21-30 years group(P<0.05). The values of SP-A1 between AK1 and AK4, AK2 and AK3, AK2 and AK4 were statistically different(P=0.008, 0.035, 0.001). CONCLUSION: The value of SP-A1 in keratoconus was positively correlated with age. In patients less than 30 years old, the SP-A1 decreased with the increase of disease severity.
format	article
author	Sheng-Wei Ren Yu-Wei Gu Li-Yan Xu Qi Fan Kai-Li Yang
author_facet	Sheng-Wei Ren Yu-Wei Gu Li-Yan Xu Qi Fan Kai-Li Yang
author_sort	Sheng-Wei Ren
title	Characteristics of corneal stiffness parameters in keratoconus patients at different ages
title_short	Characteristics of corneal stiffness parameters in keratoconus patients at different ages
title_full	Characteristics of corneal stiffness parameters in keratoconus patients at different ages
title_fullStr	Characteristics of corneal stiffness parameters in keratoconus patients at different ages
title_full_unstemmed	Characteristics of corneal stiffness parameters in keratoconus patients at different ages
title_sort	characteristics of corneal stiffness parameters in keratoconus patients at different ages
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/53cee9d4ab9b4d4abddd1638740cac87
work_keys_str_mv	AT shengweiren characteristicsofcornealstiffnessparametersinkeratoconuspatientsatdifferentages AT yuweigu characteristicsofcornealstiffnessparametersinkeratoconuspatientsatdifferentages AT liyanxu characteristicsofcornealstiffnessparametersinkeratoconuspatientsatdifferentages AT qifan characteristicsofcornealstiffnessparametersinkeratoconuspatientsatdifferentages AT kailiyang characteristicsofcornealstiffnessparametersinkeratoconuspatientsatdifferentages
_version_	1718417552765353984

Characteristics of corneal stiffness parameters in keratoconus patients at different ages

Ejemplares similares