POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity
The inflammasomes are important for activating the pro-inflammatory cytokine interleukin-β (IL-1β) for protection against pathogens. Here the authors show that a deubiquitinase, POH1, reduces the conversion of pro-IL-1β into its active form, with in vivo data further implicating a role of POH1 for m...
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Nature Portfolio
2018
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oai:doaj.org-article:53cf80a3030a473e9dc3970c56f36f6c2021-12-02T16:49:48ZPOH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity10.1038/s41467-018-06455-z2041-1723https://doaj.org/article/53cf80a3030a473e9dc3970c56f36f6c2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06455-zhttps://doaj.org/toc/2041-1723The inflammasomes are important for activating the pro-inflammatory cytokine interleukin-β (IL-1β) for protection against pathogens. Here the authors show that a deubiquitinase, POH1, reduces the conversion of pro-IL-1β into its active form, with in vivo data further implicating a role of POH1 for maintaining immune homeostasis.Li ZhangYun LiuBoshi WangGuiqin XuZhaojuan YangMing TangAihui MaTiantian JingXiaoli XuXiaoren ZhangYongzhong LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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Science Q Li Zhang Yun Liu Boshi Wang Guiqin Xu Zhaojuan Yang Ming Tang Aihui Ma Tiantian Jing Xiaoli Xu Xiaoren Zhang Yongzhong Liu POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity |
description |
The inflammasomes are important for activating the pro-inflammatory cytokine interleukin-β (IL-1β) for protection against pathogens. Here the authors show that a deubiquitinase, POH1, reduces the conversion of pro-IL-1β into its active form, with in vivo data further implicating a role of POH1 for maintaining immune homeostasis. |
format |
article |
author |
Li Zhang Yun Liu Boshi Wang Guiqin Xu Zhaojuan Yang Ming Tang Aihui Ma Tiantian Jing Xiaoli Xu Xiaoren Zhang Yongzhong Liu |
author_facet |
Li Zhang Yun Liu Boshi Wang Guiqin Xu Zhaojuan Yang Ming Tang Aihui Ma Tiantian Jing Xiaoli Xu Xiaoren Zhang Yongzhong Liu |
author_sort |
Li Zhang |
title |
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity |
title_short |
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity |
title_full |
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity |
title_fullStr |
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity |
title_full_unstemmed |
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity |
title_sort |
poh1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/53cf80a3030a473e9dc3970c56f36f6c |
work_keys_str_mv |
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