POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity

The inflammasomes are important for activating the pro-inflammatory cytokine interleukin-β (IL-1β) for protection against pathogens. Here the authors show that a deubiquitinase, POH1, reduces the conversion of pro-IL-1β into its active form, with in vivo data further implicating a role of POH1 for m...

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Autores principales: Li Zhang, Yun Liu, Boshi Wang, Guiqin Xu, Zhaojuan Yang, Ming Tang, Aihui Ma, Tiantian Jing, Xiaoli Xu, Xiaoren Zhang, Yongzhong Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/53cf80a3030a473e9dc3970c56f36f6c
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spelling oai:doaj.org-article:53cf80a3030a473e9dc3970c56f36f6c2021-12-02T16:49:48ZPOH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity10.1038/s41467-018-06455-z2041-1723https://doaj.org/article/53cf80a3030a473e9dc3970c56f36f6c2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06455-zhttps://doaj.org/toc/2041-1723The inflammasomes are important for activating the pro-inflammatory cytokine interleukin-β (IL-1β) for protection against pathogens. Here the authors show that a deubiquitinase, POH1, reduces the conversion of pro-IL-1β into its active form, with in vivo data further implicating a role of POH1 for maintaining immune homeostasis.Li ZhangYun LiuBoshi WangGuiqin XuZhaojuan YangMing TangAihui MaTiantian JingXiaoli XuXiaoren ZhangYongzhong LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Li Zhang
Yun Liu
Boshi Wang
Guiqin Xu
Zhaojuan Yang
Ming Tang
Aihui Ma
Tiantian Jing
Xiaoli Xu
Xiaoren Zhang
Yongzhong Liu
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity
description The inflammasomes are important for activating the pro-inflammatory cytokine interleukin-β (IL-1β) for protection against pathogens. Here the authors show that a deubiquitinase, POH1, reduces the conversion of pro-IL-1β into its active form, with in vivo data further implicating a role of POH1 for maintaining immune homeostasis.
format article
author Li Zhang
Yun Liu
Boshi Wang
Guiqin Xu
Zhaojuan Yang
Ming Tang
Aihui Ma
Tiantian Jing
Xiaoli Xu
Xiaoren Zhang
Yongzhong Liu
author_facet Li Zhang
Yun Liu
Boshi Wang
Guiqin Xu
Zhaojuan Yang
Ming Tang
Aihui Ma
Tiantian Jing
Xiaoli Xu
Xiaoren Zhang
Yongzhong Liu
author_sort Li Zhang
title POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity
title_short POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity
title_full POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity
title_fullStr POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity
title_full_unstemmed POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity
title_sort poh1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/53cf80a3030a473e9dc3970c56f36f6c
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