POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity

POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity

The inflammasomes are important for activating the pro-inflammatory cytokine interleukin-β (IL-1β) for protection against pathogens. Here the authors show that a deubiquitinase, POH1, reduces the conversion of pro-IL-1β into its active form, with in vivo data further implicating a role of POH1 for m...

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Autores principales: Li Zhang, Yun Liu, Boshi Wang, Guiqin Xu, Zhaojuan Yang, Ming Tang, Aihui Ma, Tiantian Jing, Xiaoli Xu, Xiaoren Zhang, Yongzhong Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/53cf80a3030a473e9dc3970c56f36f6c
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