Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms

The nucleolus is a membrane-less organelle and both Nucleophosmin (NPM1) and Surfeit locus protein 6 (SURF6) are abundant proteins within the nucleolus. Here the authors employ biophysical methods to study the properties of NPM1-S6N droplets and provide insights into the role of SURF6 in maintaining...

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Autores principales:	Mylene C. Ferrolino, Diana M. Mitrea, J. Robert Michael, Richard W. Kriwacki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53cfa7d0d2834c7394bb9f8d4f4e4c61
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spelling	oai:doaj.org-article:53cfa7d0d2834c7394bb9f8d4f4e4c612021-12-02T17:32:18ZCompositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms10.1038/s41467-018-07530-12041-1723https://doaj.org/article/53cfa7d0d2834c7394bb9f8d4f4e4c612018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07530-1https://doaj.org/toc/2041-1723The nucleolus is a membrane-less organelle and both Nucleophosmin (NPM1) and Surfeit locus protein 6 (SURF6) are abundant proteins within the nucleolus. Here the authors employ biophysical methods to study the properties of NPM1-S6N droplets and provide insights into the role of SURF6 in maintaining and modulating the liquid-like structure of the nucleolus.Mylene C. FerrolinoDiana M. MitreaJ. Robert MichaelRichard W. KriwackiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mylene C. Ferrolino Diana M. Mitrea J. Robert Michael Richard W. Kriwacki Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms
description	The nucleolus is a membrane-less organelle and both Nucleophosmin (NPM1) and Surfeit locus protein 6 (SURF6) are abundant proteins within the nucleolus. Here the authors employ biophysical methods to study the properties of NPM1-S6N droplets and provide insights into the role of SURF6 in maintaining and modulating the liquid-like structure of the nucleolus.
format	article
author	Mylene C. Ferrolino Diana M. Mitrea J. Robert Michael Richard W. Kriwacki
author_facet	Mylene C. Ferrolino Diana M. Mitrea J. Robert Michael Richard W. Kriwacki
author_sort	Mylene C. Ferrolino
title	Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms
title_short	Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms
title_full	Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms
title_fullStr	Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms
title_full_unstemmed	Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms
title_sort	compositional adaptability in npm1-surf6 scaffolding networks enabled by dynamic switching of phase separation mechanisms
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/53cfa7d0d2834c7394bb9f8d4f4e4c61
work_keys_str_mv	AT mylenecferrolino compositionaladaptabilityinnpm1surf6scaffoldingnetworksenabledbydynamicswitchingofphaseseparationmechanisms AT dianammitrea compositionaladaptabilityinnpm1surf6scaffoldingnetworksenabledbydynamicswitchingofphaseseparationmechanisms AT jrobertmichael compositionaladaptabilityinnpm1surf6scaffoldingnetworksenabledbydynamicswitchingofphaseseparationmechanisms AT richardwkriwacki compositionaladaptabilityinnpm1surf6scaffoldingnetworksenabledbydynamicswitchingofphaseseparationmechanisms
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Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms

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