Occupational exposure and radiobiological risk from thyroid radioiodine therapy in Saudi Arabia

Abstract Worldwide, thyroid cancer accounts for some 10% of total cancer incidence, most markedly for females. Thyroid cancer radiotherapy, typically using 131I (T1/2 8.02 days; β− max energy 606 keV, branching ratio 89.9%), is widely adopted as an adjunct to surgery or to treat inoperable cancer an...

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Autores principales:	H. I. Al-Mohammed, A. Sulieman, Fareed H. Mayhoub, Hassan Salah, Celestino Lagarde, M. Alkhorayef, Ali Aldhebaib, C. Kappas, D. A. Bradley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/53d14499c8984c2ab7ded3ab28ce9a00
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spelling	oai:doaj.org-article:53d14499c8984c2ab7ded3ab28ce9a002021-12-02T16:08:05ZOccupational exposure and radiobiological risk from thyroid radioiodine therapy in Saudi Arabia10.1038/s41598-021-93342-12045-2322https://doaj.org/article/53d14499c8984c2ab7ded3ab28ce9a002021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93342-1https://doaj.org/toc/2045-2322Abstract Worldwide, thyroid cancer accounts for some 10% of total cancer incidence, most markedly for females. Thyroid cancer radiotherapy, typically using 131I (T1/2 8.02 days; β− max energy 606 keV, branching ratio 89.9%), is widely adopted as an adjunct to surgery or to treat inoperable cancer and hyperthyroidism. With staff potentially receiving significant doses during source preparation and administration, radiation protection and safety assessment are required in ensuring practice complies with international guidelines. The present study, concerning a total of 206 patient radioiodine therapies carried out at King Faisal Specialist Hospital and Research Center over a 6-month period, seeks to evaluate patient and occupational exposures during hospitalization, measuring ambient doses and estimating radiation risk. Using calibrated survey meters, patient exposure dose-rate estimates were obtained at a distance of 30-, 100- and 300 cm from the neck region of each patient. Occupational and ambient doses were measured using calibrated thermoluminescent dosimeters. The mean and range of administered activity (AA, in MBq) for the thyroid cancer and hyperthyroidism treatment groups were 4244 ± 2021 (1669–8066), 1507.9 ± 324.1 (977.9–1836.9), respectively. The mean annual occupational doses were 1.2 mSv, that for ambient doses outside of the isolation room corridors were found to be 0.2 mSv, while ambient doses at the nursing station were below the lower limit of detection. Exposures to staff from patients being treated for thyroid cancer were less compared to hyperthyroidism patients. With a well-defined protocol, also complying with international safety requirements, occupational exposures were found to be relatively high, greater than most reported in previous studies.H. I. Al-MohammedA. SuliemanFareed H. MayhoubHassan SalahCelestino LagardeM. AlkhorayefAli AldhebaibC. KappasD. A. BradleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q H. I. Al-Mohammed A. Sulieman Fareed H. Mayhoub Hassan Salah Celestino Lagarde M. Alkhorayef Ali Aldhebaib C. Kappas D. A. Bradley Occupational exposure and radiobiological risk from thyroid radioiodine therapy in Saudi Arabia
description	Abstract Worldwide, thyroid cancer accounts for some 10% of total cancer incidence, most markedly for females. Thyroid cancer radiotherapy, typically using 131I (T1/2 8.02 days; β− max energy 606 keV, branching ratio 89.9%), is widely adopted as an adjunct to surgery or to treat inoperable cancer and hyperthyroidism. With staff potentially receiving significant doses during source preparation and administration, radiation protection and safety assessment are required in ensuring practice complies with international guidelines. The present study, concerning a total of 206 patient radioiodine therapies carried out at King Faisal Specialist Hospital and Research Center over a 6-month period, seeks to evaluate patient and occupational exposures during hospitalization, measuring ambient doses and estimating radiation risk. Using calibrated survey meters, patient exposure dose-rate estimates were obtained at a distance of 30-, 100- and 300 cm from the neck region of each patient. Occupational and ambient doses were measured using calibrated thermoluminescent dosimeters. The mean and range of administered activity (AA, in MBq) for the thyroid cancer and hyperthyroidism treatment groups were 4244 ± 2021 (1669–8066), 1507.9 ± 324.1 (977.9–1836.9), respectively. The mean annual occupational doses were 1.2 mSv, that for ambient doses outside of the isolation room corridors were found to be 0.2 mSv, while ambient doses at the nursing station were below the lower limit of detection. Exposures to staff from patients being treated for thyroid cancer were less compared to hyperthyroidism patients. With a well-defined protocol, also complying with international safety requirements, occupational exposures were found to be relatively high, greater than most reported in previous studies.
format	article
author	H. I. Al-Mohammed A. Sulieman Fareed H. Mayhoub Hassan Salah Celestino Lagarde M. Alkhorayef Ali Aldhebaib C. Kappas D. A. Bradley
author_facet	H. I. Al-Mohammed A. Sulieman Fareed H. Mayhoub Hassan Salah Celestino Lagarde M. Alkhorayef Ali Aldhebaib C. Kappas D. A. Bradley
author_sort	H. I. Al-Mohammed
title	Occupational exposure and radiobiological risk from thyroid radioiodine therapy in Saudi Arabia
title_short	Occupational exposure and radiobiological risk from thyroid radioiodine therapy in Saudi Arabia
title_full	Occupational exposure and radiobiological risk from thyroid radioiodine therapy in Saudi Arabia
title_fullStr	Occupational exposure and radiobiological risk from thyroid radioiodine therapy in Saudi Arabia
title_full_unstemmed	Occupational exposure and radiobiological risk from thyroid radioiodine therapy in Saudi Arabia
title_sort	occupational exposure and radiobiological risk from thyroid radioiodine therapy in saudi arabia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/53d14499c8984c2ab7ded3ab28ce9a00
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Occupational exposure and radiobiological risk from thyroid radioiodine therapy in Saudi Arabia

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