Hypoxia-induced SETX links replication stress with the unfolded protein response

Código QR

Hypoxia-induced SETX links replication stress with the unfolded protein response

Hypoxia induces a change in transcriptional response in mammalian cells. Here the authors reveal a role for the RNA/DNA helicase Senataxin in protecting cells from DNA damage induced during transcription in hypoxia.

Guardado en:

Detalles Bibliográficos
Autores principales:	Shaliny Ramachandran, Tiffany S. Ma, Jon Griffin, Natalie Ng, Iosifina P. Foskolou, Ming-Shih Hwang, Pedro Victori, Wei-Chen Cheng, Francesca M. Buffa, Katarzyna B. Leszczynska, Sherif F. El-Khamisy, Natalia Gromak, Ester M. Hammond
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53d171bea0d243d0a270df932d095042
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Descripción
Sumario:	Hypoxia induces a change in transcriptional response in mammalian cells. Here the authors reveal a role for the RNA/DNA helicase Senataxin in protecting cells from DNA damage induced during transcription in hypoxia.