Hypoxia-induced SETX links replication stress with the unfolded protein response

Hypoxia induces a change in transcriptional response in mammalian cells. Here the authors reveal a role for the RNA/DNA helicase Senataxin in protecting cells from DNA damage induced during transcription in hypoxia.

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Autores principales:	Shaliny Ramachandran, Tiffany S. Ma, Jon Griffin, Natalie Ng, Iosifina P. Foskolou, Ming-Shih Hwang, Pedro Victori, Wei-Chen Cheng, Francesca M. Buffa, Katarzyna B. Leszczynska, Sherif F. El-Khamisy, Natalia Gromak, Ester M. Hammond
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53d171bea0d243d0a270df932d095042
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spelling	oai:doaj.org-article:53d171bea0d243d0a270df932d0950422021-12-02T16:04:17ZHypoxia-induced SETX links replication stress with the unfolded protein response10.1038/s41467-021-24066-z2041-1723https://doaj.org/article/53d171bea0d243d0a270df932d0950422021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24066-zhttps://doaj.org/toc/2041-1723Hypoxia induces a change in transcriptional response in mammalian cells. Here the authors reveal a role for the RNA/DNA helicase Senataxin in protecting cells from DNA damage induced during transcription in hypoxia.Shaliny RamachandranTiffany S. MaJon GriffinNatalie NgIosifina P. FoskolouMing-Shih HwangPedro VictoriWei-Chen ChengFrancesca M. BuffaKatarzyna B. LeszczynskaSherif F. El-KhamisyNatalia GromakEster M. HammondNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shaliny Ramachandran Tiffany S. Ma Jon Griffin Natalie Ng Iosifina P. Foskolou Ming-Shih Hwang Pedro Victori Wei-Chen Cheng Francesca M. Buffa Katarzyna B. Leszczynska Sherif F. El-Khamisy Natalia Gromak Ester M. Hammond Hypoxia-induced SETX links replication stress with the unfolded protein response
description	Hypoxia induces a change in transcriptional response in mammalian cells. Here the authors reveal a role for the RNA/DNA helicase Senataxin in protecting cells from DNA damage induced during transcription in hypoxia.
format	article
author	Shaliny Ramachandran Tiffany S. Ma Jon Griffin Natalie Ng Iosifina P. Foskolou Ming-Shih Hwang Pedro Victori Wei-Chen Cheng Francesca M. Buffa Katarzyna B. Leszczynska Sherif F. El-Khamisy Natalia Gromak Ester M. Hammond
author_facet	Shaliny Ramachandran Tiffany S. Ma Jon Griffin Natalie Ng Iosifina P. Foskolou Ming-Shih Hwang Pedro Victori Wei-Chen Cheng Francesca M. Buffa Katarzyna B. Leszczynska Sherif F. El-Khamisy Natalia Gromak Ester M. Hammond
author_sort	Shaliny Ramachandran
title	Hypoxia-induced SETX links replication stress with the unfolded protein response
title_short	Hypoxia-induced SETX links replication stress with the unfolded protein response
title_full	Hypoxia-induced SETX links replication stress with the unfolded protein response
title_fullStr	Hypoxia-induced SETX links replication stress with the unfolded protein response
title_full_unstemmed	Hypoxia-induced SETX links replication stress with the unfolded protein response
title_sort	hypoxia-induced setx links replication stress with the unfolded protein response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/53d171bea0d243d0a270df932d095042
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Hypoxia-induced SETX links replication stress with the unfolded protein response

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